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Article: TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

TitleTEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
Authors
KeywordsAcute lymphoblastic leukemia
AML-1
TEL
Translocations
Issue Date1995
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leu
Citation
Leukemia, 1995, v. 9 n. 12, p. 1985-1989 How to Cite?
AbstractThe t(12;21)(p13;q22) is identified by routine cytogenetics in less than 0.05% of pediatric acute lymphoblastic leukemia (ALL) patients. This translocation encodes a TEL/AML-1 chimeric product comprising the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, fused to AML-1, the DNA-binding subunit of the AML-1/CBFβ transcription factor complex. Both TEL and AML-1 are involved in several myeloid leukemia-associated translocations with AML-1/CBFβ being altered in 20-30% of de novo acute myeloid leukemia (AML) cases. We now demonstrate that a TEL/AML1 chimeric transcript encoded by a cryptic t(12;21) is observed in 22% of pediatric ALL, making it the most common genetic lesion in these patients. Moreover, TEL/AML1 expression defined a distinct subgroup of patients characterized by an age between 1 and 10 years, B lineage immunophenotype, nonhyperdiploid DNA content and an excellent prognosis. These data demonstrate that molecular diagnostic approaches are invaluable in identifying clinically distinct subgroups, and that the AML1/CBFβ transcription complex is the most frequent target of chromosomal rearrangements in human leukemia.
Persistent Identifierhttp://hdl.handle.net/10722/79973
ISSN
2015 Impact Factor: 12.104
2015 SCImago Journal Rankings: 5.142
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShurtleff, SAen_HK
dc.contributor.authorBuijs, Aen_HK
dc.contributor.authorBehm, FGen_HK
dc.contributor.authorRubnitz, JEen_HK
dc.contributor.authorRaimondi, SCen_HK
dc.contributor.authorHancock, MLen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorPui, CHen_HK
dc.contributor.authorGrosveld, Gen_HK
dc.contributor.authorDowning, JRen_HK
dc.date.accessioned2010-09-06T08:00:55Z-
dc.date.available2010-09-06T08:00:55Z-
dc.date.issued1995en_HK
dc.identifier.citationLeukemia, 1995, v. 9 n. 12, p. 1985-1989en_HK
dc.identifier.issn0887-6924en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79973-
dc.description.abstractThe t(12;21)(p13;q22) is identified by routine cytogenetics in less than 0.05% of pediatric acute lymphoblastic leukemia (ALL) patients. This translocation encodes a TEL/AML-1 chimeric product comprising the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, fused to AML-1, the DNA-binding subunit of the AML-1/CBFβ transcription factor complex. Both TEL and AML-1 are involved in several myeloid leukemia-associated translocations with AML-1/CBFβ being altered in 20-30% of de novo acute myeloid leukemia (AML) cases. We now demonstrate that a TEL/AML1 chimeric transcript encoded by a cryptic t(12;21) is observed in 22% of pediatric ALL, making it the most common genetic lesion in these patients. Moreover, TEL/AML1 expression defined a distinct subgroup of patients characterized by an age between 1 and 10 years, B lineage immunophenotype, nonhyperdiploid DNA content and an excellent prognosis. These data demonstrate that molecular diagnostic approaches are invaluable in identifying clinically distinct subgroups, and that the AML1/CBFβ transcription complex is the most frequent target of chromosomal rearrangements in human leukemia.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leuen_HK
dc.relation.ispartofLeukemiaen_HK
dc.subjectAcute lymphoblastic leukemiaen_HK
dc.subjectAML-1en_HK
dc.subjectTELen_HK
dc.subjectTranslocationsen_HK
dc.titleTEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-6924&volume=9&spage=1985&epage=1989&date=1995&atitle=TEL/AML1+fusion+resulting+from+a+cryptic+t(12:21)+is+the+most+common+genetic+lesion+in+pediatric+ALL+and+defines+a+subgroup+of+patients+with+an+excellent+prognosisen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8609706-
dc.identifier.scopuseid_2-s2.0-13344282725en_HK
dc.identifier.hkuros22343en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13344282725&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1985en_HK
dc.identifier.epage1989en_HK
dc.identifier.isiWOS:A1995TQ15400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShurtleff, SA=7004819621en_HK
dc.identifier.scopusauthoridBuijs, A=34568177700en_HK
dc.identifier.scopusauthoridBehm, FG=35413852100en_HK
dc.identifier.scopusauthoridRubnitz, JE=7005605231en_HK
dc.identifier.scopusauthoridRaimondi, SC=7102074215en_HK
dc.identifier.scopusauthoridHancock, ML=7103248623en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridPui, CH=35376441000en_HK
dc.identifier.scopusauthoridGrosveld, G=7006196823en_HK
dc.identifier.scopusauthoridDowning, JR=7202539373en_HK

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