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Article: Review of IgG subclass and IgA deficiency in a tertiary center
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TitleReview of IgG subclass and IgA deficiency in a tertiary center
 
AuthorsChong, CY1
Lee, TL1
Ho, MHK1
Lee, SL1
Lau, YL1
 
KeywordsChinese
IgA deficiency
IgG subclass deficiency
 
Issue Date2006
 
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
CitationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 205-209+264 [How to Cite?]
 
AbstractWe retrospectively reviewed the clinical characteristics of twenty patients with IgA and/or IgG subclass deficiency attending a tertiary centre. The median age at diagnosis was 1.21 years and the median duration of follow up was 3.83 years. The most common presenting symptom was recurrent sinopulmonary infections (45%). This was followed by refractory asthma (30%), autoimmunity (15%), and other atopic manifestations (10%). Only one out of twenty patients presented with chronic gastrointestinal disease, which contrasted with the majority of previous literature. Three patients had significant pulmonary complications including bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis. The prevalence of IgA deficiency in Hong Kong Chinese population is yet to be established, though it appears not as prevalent as that in western population.
 
ISSN1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChong, CY
 
dc.contributor.authorLee, TL
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorLee, SL
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2010-09-06T08:00:52Z
 
dc.date.available2010-09-06T08:00:52Z
 
dc.date.issued2006
 
dc.description.abstractWe retrospectively reviewed the clinical characteristics of twenty patients with IgA and/or IgG subclass deficiency attending a tertiary centre. The median age at diagnosis was 1.21 years and the median duration of follow up was 3.83 years. The most common presenting symptom was recurrent sinopulmonary infections (45%). This was followed by refractory asthma (30%), autoimmunity (15%), and other atopic manifestations (10%). Only one out of twenty patients presented with chronic gastrointestinal disease, which contrasted with the majority of previous literature. Three patients had significant pulmonary complications including bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis. The prevalence of IgA deficiency in Hong Kong Chinese population is yet to be established, though it appears not as prevalent as that in western population.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 205-209+264 [How to Cite?]
 
dc.identifier.epage209+264
 
dc.identifier.hkuros120579
 
dc.identifier.issn1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-33746337597
 
dc.identifier.spage205
 
dc.identifier.urihttp://hdl.handle.net/10722/79969
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Journal of Paediatrics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectChinese
 
dc.subjectIgA deficiency
 
dc.subjectIgG subclass deficiency
 
dc.titleReview of IgG subclass and IgA deficiency in a tertiary center
 
dc.typeArticle
 
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<contributor.author>Lee, TL</contributor.author>
<contributor.author>Ho, MHK</contributor.author>
<contributor.author>Lee, SL</contributor.author>
<contributor.author>Lau, YL</contributor.author>
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<description.abstract>We retrospectively reviewed the clinical characteristics of twenty patients with IgA and/or IgG subclass deficiency attending a tertiary centre. The median age at diagnosis was 1.21 years and the median duration of follow up was 3.83 years. The most common presenting symptom was recurrent sinopulmonary infections (45%). This was followed by refractory asthma (30%), autoimmunity (15%), and other atopic manifestations (10%). Only one out of twenty patients presented with chronic gastrointestinal disease, which contrasted with the majority of previous literature. Three patients had significant pulmonary complications including bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis. The prevalence of IgA deficiency in Hong Kong Chinese population is yet to be established, though it appears not as prevalent as that in western population.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong