Article: Review of IgG subclass and IgA deficiency in a tertiary center

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TitleReview of IgG subclass and IgA deficiency in a tertiary center
AuthorsChong, CY1
Lee, TL1
Ho, MHK1
Lee, SL1
Lau, YL1
KeywordsChinese
IgA deficiency
IgG subclass deficiency
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
CitationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 205-209+264 [How to Cite?]
AbstractWe retrospectively reviewed the clinical characteristics of twenty patients with IgA and/or IgG subclass deficiency attending a tertiary centre. The median age at diagnosis was 1.21 years and the median duration of follow up was 3.83 years. The most common presenting symptom was recurrent sinopulmonary infections (45%). This was followed by refractory asthma (30%), autoimmunity (15%), and other atopic manifestations (10%). Only one out of twenty patients presented with chronic gastrointestinal disease, which contrasted with the majority of previous literature. Three patients had significant pulmonary complications including bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis. The prevalence of IgA deficiency in Hong Kong Chinese population is yet to be established, though it appears not as prevalent as that in western population.
ISSN1013-9923
2011 Impact Factor: 0.027
2011 SCImago Journal Rankings: 0.029
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChong, CY
dc.contributor.authorLee, TL
dc.contributor.authorHo, MHK
dc.contributor.authorLee, SL
dc.contributor.authorLau, YL
dc.date.accessioned2010-09-06T08:00:52Z
dc.date.available2010-09-06T08:00:52Z
dc.date.issued2006
dc.description.abstractWe retrospectively reviewed the clinical characteristics of twenty patients with IgA and/or IgG subclass deficiency attending a tertiary centre. The median age at diagnosis was 1.21 years and the median duration of follow up was 3.83 years. The most common presenting symptom was recurrent sinopulmonary infections (45%). This was followed by refractory asthma (30%), autoimmunity (15%), and other atopic manifestations (10%). Only one out of twenty patients presented with chronic gastrointestinal disease, which contrasted with the majority of previous literature. Three patients had significant pulmonary complications including bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis. The prevalence of IgA deficiency in Hong Kong Chinese population is yet to be established, though it appears not as prevalent as that in western population.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 205-209+264 [How to Cite?]
dc.identifier.epage209+264
dc.identifier.hkuros120579
dc.identifier.issn1013-9923
2011 Impact Factor: 0.027
2011 SCImago Journal Rankings: 0.029
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-33746337597
dc.identifier.spage205
dc.identifier.urihttp://hdl.handle.net/10722/79969
dc.identifier.volume11
dc.languageeng
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
dc.publisher.placeHong Kong
dc.relation.ispartofHong Kong Journal of Paediatrics
dc.relation.referencesReferences in Scopus
dc.subjectChinese
dc.subjectIgA deficiency
dc.subjectIgG subclass deficiency
dc.titleReview of IgG subclass and IgA deficiency in a tertiary center
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong