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Article: Metanephric adenofibroma: Report of a case and review of the literature

TitleMetanephric adenofibroma: Report of a case and review of the literature
Authors
KeywordsElectron microscopy
Kidney
Metanephric adenofibroma
Oncology
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1999, v. 23 n. 6, p. 727-733 How to Cite?
AbstractThe recent recognition of a variety of pediatric renal tumors of different biologic behavior places an ever-increasing demand on the surgical pathologist for an accurate diagnosis. Although metanephric adenofibroma is one of the rarest benign renal tumors, the clinical importance of correctly diagnosing it cannot be overemphasized because it can potentially be mistaken as Wilms' tumor. We describe the clinical, radiologic, and pathologic features of a case of metanephric adenofibroma and discuss its differential diagnosis. The neoplasm was composed of two discrete components: a major fibroblastic element and a minor immature epithelial element. The latter formed a small nodule beneath the renal capsule, which could barely be detected by magnetic resonance imaging. This subcapsular nodule, however, was slightly soft and tan and was distinctly different from the white, whorled cut surface of the main tumor. It was formed by closely packed small immature epithelial cells in a slightly edematous background, which was histologically identical to metanephric adenoma and closely resembled epithelial Wilms' tumor. Unlike Wilms' tumor, however, the epithelial cells were very bland with no mitoses. The main bulk of the tumor was formed by spindle fibroblastic cells that were cytologically similar to the spindle cells in congenital mesoblastic nephroma. The tumor, however, was well demarcated without the irregular infiltrating edges of congenital mesoblastic nephroma. In contrast to the randomly distributed epithelial element throughout the stromal component in previous reported cases of metanephric adenofibroma, our finding of the exceedingly small and discrete epithelial component expands the known histologic spectrum of the disease. In addition, the presence of such minute epithelial nodule underscores the importance of diligent pathologic examination and careful sampling of tissue for histologic examination.
Persistent Identifierhttp://hdl.handle.net/10722/79951
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorLuk, ISCen_HK
dc.contributor.authorPeh, WCPen_HK
dc.contributor.authorChan, KLen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-06T08:00:40Z-
dc.date.available2010-09-06T08:00:40Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1999, v. 23 n. 6, p. 727-733en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79951-
dc.description.abstractThe recent recognition of a variety of pediatric renal tumors of different biologic behavior places an ever-increasing demand on the surgical pathologist for an accurate diagnosis. Although metanephric adenofibroma is one of the rarest benign renal tumors, the clinical importance of correctly diagnosing it cannot be overemphasized because it can potentially be mistaken as Wilms' tumor. We describe the clinical, radiologic, and pathologic features of a case of metanephric adenofibroma and discuss its differential diagnosis. The neoplasm was composed of two discrete components: a major fibroblastic element and a minor immature epithelial element. The latter formed a small nodule beneath the renal capsule, which could barely be detected by magnetic resonance imaging. This subcapsular nodule, however, was slightly soft and tan and was distinctly different from the white, whorled cut surface of the main tumor. It was formed by closely packed small immature epithelial cells in a slightly edematous background, which was histologically identical to metanephric adenoma and closely resembled epithelial Wilms' tumor. Unlike Wilms' tumor, however, the epithelial cells were very bland with no mitoses. The main bulk of the tumor was formed by spindle fibroblastic cells that were cytologically similar to the spindle cells in congenital mesoblastic nephroma. The tumor, however, was well demarcated without the irregular infiltrating edges of congenital mesoblastic nephroma. In contrast to the randomly distributed epithelial element throughout the stromal component in previous reported cases of metanephric adenofibroma, our finding of the exceedingly small and discrete epithelial component expands the known histologic spectrum of the disease. In addition, the presence of such minute epithelial nodule underscores the importance of diligent pathologic examination and careful sampling of tissue for histologic examination.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectElectron microscopyen_HK
dc.subjectKidneyen_HK
dc.subjectMetanephric adenofibromaen_HK
dc.subjectOncologyen_HK
dc.titleMetanephric adenofibroma: Report of a case and review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=23&spage=727&epage=733&date=1999&atitle=Metanephric+adenofibroma:+report+of+a+case+and+review+of+the+literatureen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00000478-199906000-00014en_HK
dc.identifier.pmid10366157en_HK
dc.identifier.scopuseid_2-s2.0-0033023003en_HK
dc.identifier.hkuros43773en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033023003&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue6en_HK
dc.identifier.spage727en_HK
dc.identifier.epage733en_HK
dc.identifier.isiWOS:000080715000014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridLuk, ISC=6603553769en_HK
dc.identifier.scopusauthoridPeh, WCP=7101824981en_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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