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Article: Cytogenetic characterization of childhood hepatoblastoma

TitleCytogenetic characterization of childhood hepatoblastoma
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2000, v. 119 n. 1, p. 32-36 How to Cite?
AbstractWe describe the cytogenetic abnormalities in two cases of childhood hepatoblastoma. The first case was of fetal histology with squamous metaplasia, and cytogenetic study showed an add(5)(q31). Although an association between hepatoblastoma and familial adenomatous polyposis is recognized, the breakpoint in this case is distal to 5q21 and most probably does not involve the APC gene at that location. The second case was of macrotrabecular histology, and cytogenetic study showed an unbalanced translocation in the form of der(4)t(1;4)(q12;q34) in a hyperdiploid clone. Including our case, der(4)t(1;4)(q12;q34) has been recognized in four cases of hepatoblastoma, and it may be the first recurrent translocation in this tumor. Understanding the molecular mechanism and clinical significance of this translocation awaits analysis of more cases. (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/79943
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorChoy, Cen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChing, LMen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-09-06T08:00:34Z-
dc.date.available2010-09-06T08:00:34Z-
dc.date.issued2000en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 119 n. 1, p. 32-36en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79943-
dc.description.abstractWe describe the cytogenetic abnormalities in two cases of childhood hepatoblastoma. The first case was of fetal histology with squamous metaplasia, and cytogenetic study showed an add(5)(q31). Although an association between hepatoblastoma and familial adenomatous polyposis is recognized, the breakpoint in this case is distal to 5q21 and most probably does not involve the APC gene at that location. The second case was of macrotrabecular histology, and cytogenetic study showed an unbalanced translocation in the form of der(4)t(1;4)(q12;q34) in a hyperdiploid clone. Including our case, der(4)t(1;4)(q12;q34) has been recognized in four cases of hepatoblastoma, and it may be the first recurrent translocation in this tumor. Understanding the molecular mechanism and clinical significance of this translocation awaits analysis of more cases. (C) 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosomes, Human, Pair 1en_HK
dc.subject.meshChromosomes, Human, Pair 4en_HK
dc.subject.meshChromosomes, Human, Pair 5en_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatoblastoma - genetics - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLiver Neoplasms - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.titleCytogenetic characterization of childhood hepatoblastomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=119&spage=32&epage=36&date=2000&atitle=Cytogenetic+characterization+of+childhood+hepatoblastomaen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(99)00203-4en_HK
dc.identifier.pmid10812168-
dc.identifier.scopuseid_2-s2.0-0034100725en_HK
dc.identifier.hkuros48614en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034100725&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume119en_HK
dc.identifier.issue1en_HK
dc.identifier.spage32en_HK
dc.identifier.epage36en_HK
dc.identifier.isiWOS:000087079600006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridChoy, C=7202840937en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChing, LM=24293081200en_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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