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Article: Distribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chinese

TitleDistribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chinese
Authors
KeywordsGene polymorphism
Haemophilus influenzae
IGKV2-29
IGKVD-29
Kappa locus
Issue Date2001
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00251/index.htm
Citation
Immunogenetics, 2001, v. 53 n. 1, p. 22-30 How to Cite?
AbstractPolymorphism in the IGKV2-29 gene was shown to decrease the recombination frequency in B cells and to be important for immune responses to Haemophilus influenzae type b polysaccharide. By using the combination of PCR and restriction enzyme mapping, the distribution of IGKV2D-29 and IGKV2-29 gene alleles was estimated in two geographically and ethnically different groups. We found that V2D-29*01 homozygous individuals were most common in Swedish Caucasians (82%), but less common in the Chinese population of Hong Kong (28%). The homozygous V2D-29*02 genotype was found in 19% Chinese, but only in one Caucasian (1%). The frequency of the heterozygous V2D-29*01/V2D-29*02 genotype was also higher in the Chinese population (46%) compared with the Caucasians (7%). V2-29*01 homozygosity was more frequent among Caucasians (85%) than among Chinese (19%). In contrast, homozygous V2-29*02 individuals were over-represented in the Chinese population (18%), whereas only one was found among Caucasians (1%). Heterozygous V2-29*01/V2-29*02 individuals were also more common in the Chinese (63%) than the Caucasian (15%) population. Most Caucasians had the combination of V2D-29*01/V2D-29*01+V2-29*01/V2-29*01 (74%), while the most common genotype for Chinese was V2D-29*01/V2D-29*02+V2-29*01/V2-29*02 (41%). Analysis of the association of V2D-29*02 and V2-29*02 alleles demonstrated a high degree of linkage, as for V2D-29*01 with V2-29*01. These data show a significant difference in the distribution of IGKVD-29 and IGKV2-29 alleles among Swedish Caucasians and Hong Kong Chinese. This may help to explain differences in the occurrence of H. influenzae type b infection in the two populations. Evaluated methods for IGKV2D-29 and IGKV2-29 allele detection can be used for the screening allele polymorphisms in other particular patient groups.
Persistent Identifierhttp://hdl.handle.net/10722/79933
ISSN
2015 Impact Factor: 2.303
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPadyukov, Len_HK
dc.contributor.authorHahnZoric, Men_HK
dc.contributor.authorBlomqvist, SRen_HK
dc.contributor.authorUlanova, Men_HK
dc.contributor.authorWelch, SGen_HK
dc.contributor.authorFeeney, AJen_HK
dc.contributor.authorYu Lung Lauen_HK
dc.contributor.authorHanson, LAen_HK
dc.date.accessioned2010-09-06T08:00:27Z-
dc.date.available2010-09-06T08:00:27Z-
dc.date.issued2001en_HK
dc.identifier.citationImmunogenetics, 2001, v. 53 n. 1, p. 22-30en_HK
dc.identifier.issn0093-7711en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79933-
dc.description.abstractPolymorphism in the IGKV2-29 gene was shown to decrease the recombination frequency in B cells and to be important for immune responses to Haemophilus influenzae type b polysaccharide. By using the combination of PCR and restriction enzyme mapping, the distribution of IGKV2D-29 and IGKV2-29 gene alleles was estimated in two geographically and ethnically different groups. We found that V2D-29*01 homozygous individuals were most common in Swedish Caucasians (82%), but less common in the Chinese population of Hong Kong (28%). The homozygous V2D-29*02 genotype was found in 19% Chinese, but only in one Caucasian (1%). The frequency of the heterozygous V2D-29*01/V2D-29*02 genotype was also higher in the Chinese population (46%) compared with the Caucasians (7%). V2-29*01 homozygosity was more frequent among Caucasians (85%) than among Chinese (19%). In contrast, homozygous V2-29*02 individuals were over-represented in the Chinese population (18%), whereas only one was found among Caucasians (1%). Heterozygous V2-29*01/V2-29*02 individuals were also more common in the Chinese (63%) than the Caucasian (15%) population. Most Caucasians had the combination of V2D-29*01/V2D-29*01+V2-29*01/V2-29*01 (74%), while the most common genotype for Chinese was V2D-29*01/V2D-29*02+V2-29*01/V2-29*02 (41%). Analysis of the association of V2D-29*02 and V2-29*02 alleles demonstrated a high degree of linkage, as for V2D-29*01 with V2-29*01. These data show a significant difference in the distribution of IGKVD-29 and IGKV2-29 alleles among Swedish Caucasians and Hong Kong Chinese. This may help to explain differences in the occurrence of H. influenzae type b infection in the two populations. Evaluated methods for IGKV2D-29 and IGKV2-29 allele detection can be used for the screening allele polymorphisms in other particular patient groups.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00251/index.htmen_HK
dc.relation.ispartofImmunogeneticsen_HK
dc.subjectGene polymorphismen_HK
dc.subjectHaemophilus influenzaeen_HK
dc.subjectIGKV2-29en_HK
dc.subjectIGKVD-29en_HK
dc.subjectKappa locusen_HK
dc.titleDistribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0093-7711&volume=53&issue=1&spage=22&epage=30&date=2001&atitle=Distribution+of+human+kappa+locus+IGKV2-29+and+IGKV2D-29+alleles+in+Swedish+Caucasians+and+Hong+Kong+Chineseen_HK
dc.identifier.emailYu Lung Lau:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityYu Lung Lau=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s002510000291en_HK
dc.identifier.pmid11261927-
dc.identifier.scopuseid_2-s2.0-0035094332en_HK
dc.identifier.hkuros56728en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035094332&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue1en_HK
dc.identifier.spage22en_HK
dc.identifier.epage30en_HK
dc.identifier.isiWOS:000167423900004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridPadyukov, L=6603725900en_HK
dc.identifier.scopusauthoridHahnZoric, M=7003445850en_HK
dc.identifier.scopusauthoridBlomqvist, SR=36819964000en_HK
dc.identifier.scopusauthoridUlanova, M=7004196910en_HK
dc.identifier.scopusauthoridWelch, SG=7101674165en_HK
dc.identifier.scopusauthoridFeeney, AJ=7006158789en_HK
dc.identifier.scopusauthoridYu Lung Lau=7201403380en_HK
dc.identifier.scopusauthoridHanson, LA=7201657486en_HK

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