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Article: Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

TitleAssociation of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese
Authors
KeywordsInterferon gamma
Interleukin 10
Susceptibility
Tuberculosis
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
Citation
Genes And Immunity, 2005, v. 6 n. 4, p. 358-363 How to Cite?
AbstractInterferon gamma (IFN-γ) and interleukin 10(IL-10) are believed to play opposing roles in host immunity against mycobacterial infection. IFN-γ activates macrophages, while IL-10 downregulates the expression of T helper type 1 cytokines, MHC class II antigens and costimulatory molecules on macrophages. Associations of IFN-γ - 179 (G/T), + 874 (A/T), + 875 miscrosatellite CA repeats and + 4766 (C/T), and IL-10 - 1082 (A/G), -819 (C/T) and -592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population. The frequency of a low IFN-γ-producing +874 A/A genotype was significantly over-represented in the patient group (P < 0.001, OR = 3.79, 95% CI = 1.93-7.45). We identified 10 alleles in the IFN-γ CA repeats and observed a significant difference in allele frequency distribution between patients and controls (P < 0.001). By grouping alleles into 12 and non-12 CA repeats, the non-12/non-12 genotype yielded a similar significant result (P < 0.001, OR = 4.56, 95% CI = 2.21-9.43) as observed in + 874 A/A genotype. Weak associations of the IL-10 GCC/- genotype (P = 0.04) and the low IFN-γ-producing A/A genotype (P = 0.06) with TB relapse/extrapulmonary cases were found. This study suggests the possible role of interferon gamma in TB susceptibility. © 2005 Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79923
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.636
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTso, HWen_HK
dc.contributor.authorIp, WKen_HK
dc.contributor.authorChong, WPen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:00:20Z-
dc.date.available2010-09-06T08:00:20Z-
dc.date.issued2005en_HK
dc.identifier.citationGenes And Immunity, 2005, v. 6 n. 4, p. 358-363en_HK
dc.identifier.issn1466-4879en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79923-
dc.description.abstractInterferon gamma (IFN-γ) and interleukin 10(IL-10) are believed to play opposing roles in host immunity against mycobacterial infection. IFN-γ activates macrophages, while IL-10 downregulates the expression of T helper type 1 cytokines, MHC class II antigens and costimulatory molecules on macrophages. Associations of IFN-γ - 179 (G/T), + 874 (A/T), + 875 miscrosatellite CA repeats and + 4766 (C/T), and IL-10 - 1082 (A/G), -819 (C/T) and -592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population. The frequency of a low IFN-γ-producing +874 A/A genotype was significantly over-represented in the patient group (P < 0.001, OR = 3.79, 95% CI = 1.93-7.45). We identified 10 alleles in the IFN-γ CA repeats and observed a significant difference in allele frequency distribution between patients and controls (P < 0.001). By grouping alleles into 12 and non-12 CA repeats, the non-12/non-12 genotype yielded a similar significant result (P < 0.001, OR = 4.56, 95% CI = 2.21-9.43) as observed in + 874 A/A genotype. Weak associations of the IL-10 GCC/- genotype (P = 0.04) and the low IFN-γ-producing A/A genotype (P = 0.06) with TB relapse/extrapulmonary cases were found. This study suggests the possible role of interferon gamma in TB susceptibility. © 2005 Nature Publishing Group. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/geneen_HK
dc.relation.ispartofGenes and Immunityen_HK
dc.subjectInterferon gammaen_HK
dc.subjectInterleukin 10en_HK
dc.subjectSusceptibilityen_HK
dc.subjectTuberculosisen_HK
dc.titleAssociation of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1466-4879&volume=6&spage=358&epage=363&date=2005&atitle=Association+of+interferon+gamma+and+interleukin+10+genes+with+tuberculosis+in+Hong+Kong+Chineseen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.gene.6364189en_HK
dc.identifier.pmid15815688-
dc.identifier.scopuseid_2-s2.0-21344443711en_HK
dc.identifier.hkuros98416en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21344443711&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage358en_HK
dc.identifier.epage363en_HK
dc.identifier.isiWOS:000229465600011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTso, HW=7003664344en_HK
dc.identifier.scopusauthoridIp, WK=35083568800en_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridTam, CM=7201442997en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike151913-

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