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Article: Avian influenza virus signaling: Implications for the disease severity of H5N1 infection

TitleAvian influenza virus signaling: Implications for the disease severity of H5N1 infection
Authors
KeywordsAvian influenza virus
Cytokine
Kinase
Signaling pathways
Issue Date2007
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.signaltrans.de
Citation
Signal Transduction, 2007, v. 7 n. 1, p. 64-80 How to Cite?
AbstractThe global outbreak of avian influenza virus infections in poultry and wild birds as well as the high mortality rate in patients infected with the viruses pose a worldwide alert to the risk of an emerging epidemic. Scientific data to date showed some strains of avian influenza viruses including H5N1 are capable of going through mutations to develop into a novel, pandemic strain of influenza virus. Recent research has advanced our knowledge of the biological behavior of the virus, its interactions with mammalian cells, downstream signal transduction pathways, and the antiviral immune responses. A better understanding of the virus-activated signaling pathways will provide new clues to delineate the mechanisms underlying the pathogenesis of avian influenza virus infection. Here, we reviewed the contributions of human and avian influenza virus virulence factors including hemagglutinin HA, RNA polymerase, and nonstructural protein NS1. We next discussed the interaction of the viruses with cellular factors including Toll-like receptor TLR, RIG-I/MDA5, signaling kinases including PKR, MAPK and PI3K, and transcription factors NF-κB and IRF. Finally, we commented on the role of apoptosis and caspase activation as important host defense mechanisms. Taken together, virus replication and its activated inflammation contribute to the severity of avian influenza infections. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/79922
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorLee, DCWen_HK
dc.contributor.authorLau, ASYen_HK
dc.date.accessioned2010-09-06T08:00:20Z-
dc.date.available2010-09-06T08:00:20Z-
dc.date.issued2007en_HK
dc.identifier.citationSignal Transduction, 2007, v. 7 n. 1, p. 64-80en_HK
dc.identifier.issn1615-4053en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79922-
dc.description.abstractThe global outbreak of avian influenza virus infections in poultry and wild birds as well as the high mortality rate in patients infected with the viruses pose a worldwide alert to the risk of an emerging epidemic. Scientific data to date showed some strains of avian influenza viruses including H5N1 are capable of going through mutations to develop into a novel, pandemic strain of influenza virus. Recent research has advanced our knowledge of the biological behavior of the virus, its interactions with mammalian cells, downstream signal transduction pathways, and the antiviral immune responses. A better understanding of the virus-activated signaling pathways will provide new clues to delineate the mechanisms underlying the pathogenesis of avian influenza virus infection. Here, we reviewed the contributions of human and avian influenza virus virulence factors including hemagglutinin HA, RNA polymerase, and nonstructural protein NS1. We next discussed the interaction of the viruses with cellular factors including Toll-like receptor TLR, RIG-I/MDA5, signaling kinases including PKR, MAPK and PI3K, and transcription factors NF-κB and IRF. Finally, we commented on the role of apoptosis and caspase activation as important host defense mechanisms. Taken together, virus replication and its activated inflammation contribute to the severity of avian influenza infections. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.signaltrans.deen_HK
dc.relation.ispartofSignal Transductionen_HK
dc.subjectAvian influenza virusen_HK
dc.subjectCytokineen_HK
dc.subjectKinaseen_HK
dc.subjectSignaling pathwaysen_HK
dc.titleAvian influenza virus signaling: Implications for the disease severity of H5N1 infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-4053&volume=7&spage=64&epage=80&date=2007&atitle=Avian+influenza+virus+signaling:+implications+for+the+disease+severity+of+H5N1+infectionen_HK
dc.identifier.emailLau, ASY:asylau@hku.hken_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/sita.200600117en_HK
dc.identifier.scopuseid_2-s2.0-33847284989en_HK
dc.identifier.hkuros126106en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847284989&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.spage64en_HK
dc.identifier.epage80en_HK
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLee, DCW=15751156000en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK

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