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Article: Cerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginase

TitleCerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginase
Authors
KeywordsCerebral thrombosis
Childhood acute lymphoblastic leukaemia
L-asparaginase
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 69-72 How to Cite?
AbstractThe occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction during the third week of induction therapy which consists of relatively low dose E. coli asparaginase (6,000 iu/m 2/dose three times weekly). Altered hemostatic profile was observed in both patients during the attack but they were likely to be induced by the asparaginase treatment as shown by the return of normal profile in the post-chemotherapy period for the survived patient. There were inconsistent observations on the role of pre-existing prothrombotic conditions in previous studies and our findings further suggest that the cause is likely to be multifactorial. More investigations are needed to clarify if co-existing prothrombotic defects, either inherited or acquired, play a significant role in the causation of thrombosis in local childhood ALL patients receiving asparaginase therapy.
Persistent Identifierhttp://hdl.handle.net/10722/79916
ISSN
2014 Impact Factor: 0.133
2014 SCImago Journal Rankings: 0.126
References

 

DC FieldValueLanguage
dc.contributor.authorPesqueraLepatan, LMen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLam, Cen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:00:15Z-
dc.date.available2010-09-06T08:00:15Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 69-72en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79916-
dc.description.abstractThe occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction during the third week of induction therapy which consists of relatively low dose E. coli asparaginase (6,000 iu/m 2/dose three times weekly). Altered hemostatic profile was observed in both patients during the attack but they were likely to be induced by the asparaginase treatment as shown by the return of normal profile in the post-chemotherapy period for the survived patient. There were inconsistent observations on the role of pre-existing prothrombotic conditions in previous studies and our findings further suggest that the cause is likely to be multifactorial. More investigations are needed to clarify if co-existing prothrombotic defects, either inherited or acquired, play a significant role in the causation of thrombosis in local childhood ALL patients receiving asparaginase therapy.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectCerebral thrombosisen_HK
dc.subjectChildhood acute lymphoblastic leukaemiaen_HK
dc.subjectL-asparaginaseen_HK
dc.titleCerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=69&epage=72&date=2006&atitle=Cerebral+Infarction+in+Childhood+Acute+Lymphoblastic+Leukaemia+Treated+with+Low+Dose+E.+coli+Asparaginaseen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-31344441085en_HK
dc.identifier.hkuros114553en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344441085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage69en_HK
dc.identifier.epage72en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridPesqueraLepatan, LM=11940539000en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLam, C=16947291300en_HK
dc.identifier.scopusauthoridHo, MHK=36554116300en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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