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Article: Cerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginase
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TitleCerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginase
 
AuthorsPesqueraLepatan, LM2
Chan, GCF1
Lam, C1
Ho, MHK1
Lee, TL1
Chiang, AKS1
Ha, SY1
Lau, YL1
 
KeywordsCerebral thrombosis
Childhood acute lymphoblastic leukaemia
L-asparaginase
 
Issue Date2006
 
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
CitationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 69-72 [How to Cite?]
 
AbstractThe occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction during the third week of induction therapy which consists of relatively low dose E. coli asparaginase (6,000 iu/m 2/dose three times weekly). Altered hemostatic profile was observed in both patients during the attack but they were likely to be induced by the asparaginase treatment as shown by the return of normal profile in the post-chemotherapy period for the survived patient. There were inconsistent observations on the role of pre-existing prothrombotic conditions in previous studies and our findings further suggest that the cause is likely to be multifactorial. More investigations are needed to clarify if co-existing prothrombotic defects, either inherited or acquired, play a significant role in the causation of thrombosis in local childhood ALL patients receiving asparaginase therapy.
 
ISSN1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPesqueraLepatan, LM
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorLam, C
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorLee, TL
 
dc.contributor.authorChiang, AKS
 
dc.contributor.authorHa, SY
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2010-09-06T08:00:15Z
 
dc.date.available2010-09-06T08:00:15Z
 
dc.date.issued2006
 
dc.description.abstractThe occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction during the third week of induction therapy which consists of relatively low dose E. coli asparaginase (6,000 iu/m 2/dose three times weekly). Altered hemostatic profile was observed in both patients during the attack but they were likely to be induced by the asparaginase treatment as shown by the return of normal profile in the post-chemotherapy period for the survived patient. There were inconsistent observations on the role of pre-existing prothrombotic conditions in previous studies and our findings further suggest that the cause is likely to be multifactorial. More investigations are needed to clarify if co-existing prothrombotic defects, either inherited or acquired, play a significant role in the causation of thrombosis in local childhood ALL patients receiving asparaginase therapy.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 69-72 [How to Cite?]
 
dc.identifier.epage72
 
dc.identifier.hkuros114553
 
dc.identifier.issn1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-31344441085
 
dc.identifier.spage69
 
dc.identifier.urihttp://hdl.handle.net/10722/79916
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Journal of Paediatrics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCerebral thrombosis
 
dc.subjectChildhood acute lymphoblastic leukaemia
 
dc.subjectL-asparaginase
 
dc.titleCerebral infarction in childhood acute lymphoblastic leukaemia treated with low dose E. coli Asparaginase
 
dc.typeArticle
 
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<contributor.author>Ho, MHK</contributor.author>
<contributor.author>Lee, TL</contributor.author>
<contributor.author>Chiang, AKS</contributor.author>
<contributor.author>Ha, SY</contributor.author>
<contributor.author>Lau, YL</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Santo Tomas Hospital