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Article: A cross-sectional study of growth, puberty and endocrine function in patients with thalassaemia major in Hong Kong

TitleA cross-sectional study of growth, puberty and endocrine function in patients with thalassaemia major in Hong Kong
Authors
KeywordsGrowth hormone
Insulin-like growth factor
Thalassaemia major
Issue Date1995
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPC
Citation
Journal Of Paediatrics And Child Health, 1995, v. 31 n. 2, p. 83-87 How to Cite?
AbstractMethodology: A cross-sectional study of growth, puberty and endocrine function was performed on 35 girls and 33 boys with thalassaemia major. Results: Despite regular transfusion and chelation therapy, 75% of the girls and 62% of the boys over the age of 12 years were below the third percentile for height. Hypogonadotropic hypogonadism was found in a similar percentage of patients. Moderate to marked zinc deficiency secondary to chelation therapy was considered unlikely because normal serum zinc levels were found in all but three of our patients, but we could not exclude the possibility of a marginal status of zinc nutrition causing growth failure. Growth hormone deficiency and diabetes mellitus were sometimes encountered but hypothyroidism, hypoparathyroidism and adrenal Insufficiency were rare among our patients. Most of the patients with growth failure had normal growth hormone (GH) response to insulin induced hypoglycaemia. The serum insulin-like growth factor-1 (IGF-1) levels were low in our patients and no significant difference in the serum IGF-1 levels was found between prepubertal children with or without growth failure (0.4 ± 0.1 mU/mL vs 0.37 ± 0.11 mU/mL, P = 0.39). Similarly, no difference in the serum IGF-1 levels was found between pubertal children with or without growth failure (0.48 ± 0.2 U/mL vs 0.56 ± 0.14 U/mL, P = 0.26). Conclusions: Delayed sexual maturation and a possible defect in growth unrelated to the GH-IGF-1 axis may be responsible for the growth failure in adolescent children with thalassaemia major.
Persistent Identifierhttp://hdl.handle.net/10722/79911
ISSN
2015 Impact Factor: 1.477
2015 SCImago Journal Rankings: 0.692
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwan, EYWen_HK
dc.contributor.authorLee, ACen_HK
dc.contributor.authorLi, AMCen_HK
dc.contributor.authorTam, SCFen_HK
dc.contributor.authorChan, CFen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorLow, LCKen_HK
dc.date.accessioned2010-09-06T08:00:11Z-
dc.date.available2010-09-06T08:00:11Z-
dc.date.issued1995en_HK
dc.identifier.citationJournal Of Paediatrics And Child Health, 1995, v. 31 n. 2, p. 83-87en_HK
dc.identifier.issn1034-4810en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79911-
dc.description.abstractMethodology: A cross-sectional study of growth, puberty and endocrine function was performed on 35 girls and 33 boys with thalassaemia major. Results: Despite regular transfusion and chelation therapy, 75% of the girls and 62% of the boys over the age of 12 years were below the third percentile for height. Hypogonadotropic hypogonadism was found in a similar percentage of patients. Moderate to marked zinc deficiency secondary to chelation therapy was considered unlikely because normal serum zinc levels were found in all but three of our patients, but we could not exclude the possibility of a marginal status of zinc nutrition causing growth failure. Growth hormone deficiency and diabetes mellitus were sometimes encountered but hypothyroidism, hypoparathyroidism and adrenal Insufficiency were rare among our patients. Most of the patients with growth failure had normal growth hormone (GH) response to insulin induced hypoglycaemia. The serum insulin-like growth factor-1 (IGF-1) levels were low in our patients and no significant difference in the serum IGF-1 levels was found between prepubertal children with or without growth failure (0.4 ± 0.1 mU/mL vs 0.37 ± 0.11 mU/mL, P = 0.39). Similarly, no difference in the serum IGF-1 levels was found between pubertal children with or without growth failure (0.48 ± 0.2 U/mL vs 0.56 ± 0.14 U/mL, P = 0.26). Conclusions: Delayed sexual maturation and a possible defect in growth unrelated to the GH-IGF-1 axis may be responsible for the growth failure in adolescent children with thalassaemia major.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPCen_HK
dc.relation.ispartofJournal of Paediatrics and Child Healthen_HK
dc.subjectGrowth hormoneen_HK
dc.subjectInsulin-like growth factoren_HK
dc.subjectThalassaemia majoren_HK
dc.titleA cross-sectional study of growth, puberty and endocrine function in patients with thalassaemia major in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1034-4810&volume=31&spage=83&epage=87&date=1995&atitle=A+cross-sectional+study+of+growth,+puberty+and+endocrine+function+in+patients+with+thalassaemia+major+in+Hong+Kongen_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1754.1995.tb00752.x-
dc.identifier.pmid7794630en_HK
dc.identifier.scopuseid_2-s2.0-0028916627en_HK
dc.identifier.hkuros2360en_HK
dc.identifier.volume31en_HK
dc.identifier.issue2en_HK
dc.identifier.spage83en_HK
dc.identifier.epage87en_HK
dc.identifier.isiWOS:A1995QT90500005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridKwan, EYW=7006484387en_HK
dc.identifier.scopusauthoridLee, AC=7405631431en_HK
dc.identifier.scopusauthoridLi, AMC=7403291810en_HK
dc.identifier.scopusauthoridTam, SCF=7202037323en_HK
dc.identifier.scopusauthoridChan, CF=36984590800en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK

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