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Article: Expression of NMDA receptor-1 induced by NMDA in the brain of neonatal SD rats

TitleExpression of NMDA receptor-1 induced by NMDA in the brain of neonatal SD rats
Authors
KeywordsBrain
Neonatal SD rat
NMDA receptor-1
Issue Date2006
Citation
Journal Of Central South University (Medical Sciences), 2006, v. 31 n. 1, p. 52-55+69 How to Cite?
AbstractObjective: To determine the regulation of the expression of NMDA receptor-1 induced by NMDA in the brain of neonatal SD rats. Methods: Neonatal SD rats (n = 90) were randomly divided into normal control (n = 6) and NMDA injected group (subdivided into 10 nmol-0 min, 15 min, 30 min, 1 h, 2 h, 4 h groups, and 10, 20, 50 nmol groups, each n = 6). NMDA fluorescent inmmunohistological staining and TTC (2,3,5-triphenyltetrazolium chloride) staining techniques were used. Results: At 30 min after the injection of 10 nmol NMDA, a few NR1 positive cells could be observed along the injection tract. At 1 h after the injection, NR1 positive cells in large quantity could be observed in the hippocampal CA1 region and paraventricular thalamus of the ipsilateral hemisphere. The number and location of positive cells at 2 h and 4 h after the injection were not much different from that at 1 h after the injection. At 2 h after injection, stronger NR1 expression was observed in the 50 nmol injection group. In addition, slight crinkle of the cell wall with mild condensation of the nuclei was also observed in the 50 nmol injection group. At 2 h after the injection, no abnormality was observed in 10, 20, or 50 nmol group after TTC staining. Conclusion: The NR1 induced by NMDA is expressed in a time-dependent and dose-dependent pattern after a short period of "delay", providing a possible "therapeutic window" for using NMDA receptor antagonist to treat diseases relating to the NMDA receptor activation.
Persistent Identifierhttp://hdl.handle.net/10722/79906
ISSN
2015 SCImago Journal Rankings: 0.142
References

 

DC FieldValueLanguage
dc.contributor.authorHei, MYen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorCheung, PTen_HK
dc.date.accessioned2010-09-06T08:00:08Z-
dc.date.available2010-09-06T08:00:08Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Central South University (Medical Sciences), 2006, v. 31 n. 1, p. 52-55+69en_HK
dc.identifier.issn1672-7347en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79906-
dc.description.abstractObjective: To determine the regulation of the expression of NMDA receptor-1 induced by NMDA in the brain of neonatal SD rats. Methods: Neonatal SD rats (n = 90) were randomly divided into normal control (n = 6) and NMDA injected group (subdivided into 10 nmol-0 min, 15 min, 30 min, 1 h, 2 h, 4 h groups, and 10, 20, 50 nmol groups, each n = 6). NMDA fluorescent inmmunohistological staining and TTC (2,3,5-triphenyltetrazolium chloride) staining techniques were used. Results: At 30 min after the injection of 10 nmol NMDA, a few NR1 positive cells could be observed along the injection tract. At 1 h after the injection, NR1 positive cells in large quantity could be observed in the hippocampal CA1 region and paraventricular thalamus of the ipsilateral hemisphere. The number and location of positive cells at 2 h and 4 h after the injection were not much different from that at 1 h after the injection. At 2 h after injection, stronger NR1 expression was observed in the 50 nmol injection group. In addition, slight crinkle of the cell wall with mild condensation of the nuclei was also observed in the 50 nmol injection group. At 2 h after the injection, no abnormality was observed in 10, 20, or 50 nmol group after TTC staining. Conclusion: The NR1 induced by NMDA is expressed in a time-dependent and dose-dependent pattern after a short period of "delay", providing a possible "therapeutic window" for using NMDA receptor antagonist to treat diseases relating to the NMDA receptor activation.en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of Central South University (Medical Sciences)en_HK
dc.subjectBrainen_HK
dc.subjectNeonatal SD raten_HK
dc.subjectNMDA receptor-1en_HK
dc.titleExpression of NMDA receptor-1 induced by NMDA in the brain of neonatal SD ratsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, PT:ptcheung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, PT=rp00351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16562675-
dc.identifier.scopuseid_2-s2.0-33644911184en_HK
dc.identifier.hkuros127707en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644911184&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue1en_HK
dc.identifier.spage52en_HK
dc.identifier.epage55+69en_HK
dc.identifier.scopusauthoridHei, MY=12780885700en_HK
dc.identifier.scopusauthoridLi, Y=7502084913en_HK
dc.identifier.scopusauthoridCheung, PT=7202595465en_HK

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