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Article: The use of methotrexate in juvenile idiopathic arthritis: A single center experience

TitleThe use of methotrexate in juvenile idiopathic arthritis: A single center experience
Authors
KeywordsJuvenile idiopathic arthritis
Methotrexate
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 191-198+263 How to Cite?
AbstractIn the recent decade, an increasing number of disease-modifying anti-rheumatic drugs (DMARDs) have been developed for treatment in juvenile idiopathic arthritis (JIA). Currently, methotrexate (MTX) is the DMARD of first choice particularly in oligoarticular and polyarticular JIA, but its efficacy in systemic-onset JIA and enthesitis-related JIA was less satisfactory. A retrospective study on 40 patients followed up at Queen Mary Hospital for JIA was performed to review the treatment outcome and adverse effects associated with use of MTX. We concluded that MTX was safe and well tolerated in majority of patients, but treatment response varied with different JIA subtypes. Combination of MTX with other antiinflammatory agents was often required to achieve disease remission in patients with more severe disease. Large, randomised controlled trials are needed to determine the efficacy of individual drug and their combination in each JIA subtype.
Persistent Identifierhttp://hdl.handle.net/10722/79884
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:59:50Z-
dc.date.available2010-09-06T07:59:50Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 191-198+263en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79884-
dc.description.abstractIn the recent decade, an increasing number of disease-modifying anti-rheumatic drugs (DMARDs) have been developed for treatment in juvenile idiopathic arthritis (JIA). Currently, methotrexate (MTX) is the DMARD of first choice particularly in oligoarticular and polyarticular JIA, but its efficacy in systemic-onset JIA and enthesitis-related JIA was less satisfactory. A retrospective study on 40 patients followed up at Queen Mary Hospital for JIA was performed to review the treatment outcome and adverse effects associated with use of MTX. We concluded that MTX was safe and well tolerated in majority of patients, but treatment response varied with different JIA subtypes. Combination of MTX with other antiinflammatory agents was often required to achieve disease remission in patients with more severe disease. Large, randomised controlled trials are needed to determine the efficacy of individual drug and their combination in each JIA subtype.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectJuvenile idiopathic arthritisen_HK
dc.subjectMethotrexateen_HK
dc.titleThe use of methotrexate in juvenile idiopathic arthritis: A single center experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=191&epage=198&date=2006&atitle=The+use+of+methotrexate+in+juvenile+idiopathic+arthritis:+a+single+center+experienceen_HK
dc.identifier.emailLee, PPW:ppwlee@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLee, PPW=rp00462en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33746326454en_HK
dc.identifier.hkuros120583en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746326454&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage191en_HK
dc.identifier.epage198+263en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLee, PPW=14048822200en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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