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Article: Allergen sensitization of asthmatic and nonasthmatic schoolchildren in Costa Rica

TitleAllergen sensitization of asthmatic and nonasthmatic schoolchildren in Costa Rica
Authors
KeywordsAllergens
Asthma
Childhood
Issue Date1998
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ALL
Citation
Allergy: European Journal Of Allergy And Clinical Immunology, 1998, v. 53 n. 12, p. 1141-1147 How to Cite?
AbstractThe prevalence of asthma among schoolchildren in Costa Rica is very high at the level of 20-30% - and the reason is still unknown. A group of children from our previous epidemiologic study was randomly selected in order to establish the relation between asthma symptoms and allergy sensitization to common allergens. Serum samples from children with and without asthma were analyzed for the presence of IgE antibodies to 36 different allergens, for the presence of IgE antibodies to a pool of 10 common allergens, and for total serum IgE. The most prevalent IgE antibodies were those to mite, cockroach, dog, and house-dust allergens with MAST pipettes for the serologic measurements. Positive reactions to house dust, mite, cat, and the two molds (Alternaria and Cladosporium), and food allergens such as egg white, peanut, and shellfish were significantly more prevalent among the asthmatics than the nonasthmatics. Sensitization was equally prevalent at different ages, but the house-dust, mite, cat, dog, cockroach, Alternaria, and egg-white allergens had sensitized boys more often than girls (P<0.01). The result of the analysis of IgE antibodies to a pool of 10 common allergens by Phadiatop supported the MAST pipette results, showing allergen sensitization in 57.7% of the asthmatic children and 42.3% in the nonasthmatic group. The concentration of IgE was significantly higher among the asthmatic children (372.2 kU/1) than among the nonasthmatic children (249.1 kU/l) (P < 0.00001). Parasitic infestations were not examined in this study, but in most of Costa Rica these have largely been eliminated and could not explain the high total IgE levels. Our data indicate that the very high prevalence of bronchial asthma in Costa Rican schoolchildren can be related to sensitization, especially to airborne indoor allergens such as those of mites, cockroaches, and dogs.
Persistent Identifierhttp://hdl.handle.net/10722/79883
ISSN
2015 Impact Factor: 6.335
2015 SCImago Journal Rankings: 3.048
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSotoQuiros, Men_HK
dc.contributor.authorGutierrez, Ien_HK
dc.contributor.authorCalvo, Nen_HK
dc.contributor.authorAraya, Cen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorHanson, LÅen_HK
dc.contributor.authorBelin, Len_HK
dc.date.accessioned2010-09-06T07:59:49Z-
dc.date.available2010-09-06T07:59:49Z-
dc.date.issued1998en_HK
dc.identifier.citationAllergy: European Journal Of Allergy And Clinical Immunology, 1998, v. 53 n. 12, p. 1141-1147en_HK
dc.identifier.issn0105-4538en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79883-
dc.description.abstractThe prevalence of asthma among schoolchildren in Costa Rica is very high at the level of 20-30% - and the reason is still unknown. A group of children from our previous epidemiologic study was randomly selected in order to establish the relation between asthma symptoms and allergy sensitization to common allergens. Serum samples from children with and without asthma were analyzed for the presence of IgE antibodies to 36 different allergens, for the presence of IgE antibodies to a pool of 10 common allergens, and for total serum IgE. The most prevalent IgE antibodies were those to mite, cockroach, dog, and house-dust allergens with MAST pipettes for the serologic measurements. Positive reactions to house dust, mite, cat, and the two molds (Alternaria and Cladosporium), and food allergens such as egg white, peanut, and shellfish were significantly more prevalent among the asthmatics than the nonasthmatics. Sensitization was equally prevalent at different ages, but the house-dust, mite, cat, dog, cockroach, Alternaria, and egg-white allergens had sensitized boys more often than girls (P<0.01). The result of the analysis of IgE antibodies to a pool of 10 common allergens by Phadiatop supported the MAST pipette results, showing allergen sensitization in 57.7% of the asthmatic children and 42.3% in the nonasthmatic group. The concentration of IgE was significantly higher among the asthmatic children (372.2 kU/1) than among the nonasthmatic children (249.1 kU/l) (P < 0.00001). Parasitic infestations were not examined in this study, but in most of Costa Rica these have largely been eliminated and could not explain the high total IgE levels. Our data indicate that the very high prevalence of bronchial asthma in Costa Rican schoolchildren can be related to sensitization, especially to airborne indoor allergens such as those of mites, cockroaches, and dogs.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ALLen_HK
dc.relation.ispartofAllergy: European Journal of Allergy and Clinical Immunologyen_HK
dc.subjectAllergensen_HK
dc.subjectAsthmaen_HK
dc.subjectChildhooden_HK
dc.titleAllergen sensitization of asthmatic and nonasthmatic schoolchildren in Costa Ricaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0105-4538&volume=53&spage=1141&epage=1147&date=1998&atitle=Allergen+sensitization+of+asthmatic+and+nonasthmatic+schoolchildren+in+Costa+Ricaen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9930589-
dc.identifier.scopuseid_2-s2.0-0032418079en_HK
dc.identifier.hkuros40870en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032418079&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1141en_HK
dc.identifier.epage1147en_HK
dc.identifier.isiWOS:000078204300005-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridSotoQuiros, M=6602775508en_HK
dc.identifier.scopusauthoridGutierrez, I=7005865310en_HK
dc.identifier.scopusauthoridCalvo, N=9242045400en_HK
dc.identifier.scopusauthoridAraya, C=6602140622en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridHanson, LÅ=7201657486en_HK
dc.identifier.scopusauthoridBelin, L=7004580255en_HK

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