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Article: The therapeutic use of growth-hormone-releasing hormone

TitleThe therapeutic use of growth-hormone-releasing hormone
Authors
Issue Date1993
PublisherFreund Publishing House, Ltd. The Journal's web site is located at http://www.freundpublishing.com/Journal_Pediatric_Endocrinology_Metabolism/JPEMprev.htm
Citation
Journal Of Pediatric Endocrinology, 1993, v. 6 n. 1, p. 15-20 How to Cite?
AbstractAs a significant number of children with growth hormone deficiency have been shown to be able to respond to GHRH with a rise in serum growth hormone (GH) levels, GHRH has been used to treat such children with varying success. GHRH has been given subcutaneously (SC) in GH deficient children to improve growth in dose frequencies of daily, twice daily, three-hourly overnight or three-hourly throughout the day. The dosages of GHRH used have been wide ranging, varying from 4 μg/kg/day to 50 μg/kg/day. Continuous infusion of GHRH has been shown to augment GH secretion in normal adults and GH deficient children without evidence of densensitization of the somatotrophs. Continuous SC infusion of GHRH has been shown to promote growth in short slowly growing children. Poor growth response to GHRH has been reported by some authors using daily SC injection while others reported significant growth acceleration in 42-87% of GH deficient children treated using different GHRH regimes. Although GH treatment in GH-deficient children results in more consistent growth acceleration, comparable growth response can be seen in some children treated with GHRH. The optimal mode of GHRH therapy remains to be determined, but it would appear that the growth response is dependent on the dose used and possibly on the frequency of administration. The development of a sustained release preparation of GHRH may prove to be an alternative to GH in the treatment of some Children with short stature.
Persistent Identifierhttp://hdl.handle.net/10722/79865
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.493
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLow, LCKen_HK
dc.date.accessioned2010-09-06T07:59:37Z-
dc.date.available2010-09-06T07:59:37Z-
dc.date.issued1993en_HK
dc.identifier.citationJournal Of Pediatric Endocrinology, 1993, v. 6 n. 1, p. 15-20en_HK
dc.identifier.issn0334-018Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79865-
dc.description.abstractAs a significant number of children with growth hormone deficiency have been shown to be able to respond to GHRH with a rise in serum growth hormone (GH) levels, GHRH has been used to treat such children with varying success. GHRH has been given subcutaneously (SC) in GH deficient children to improve growth in dose frequencies of daily, twice daily, three-hourly overnight or three-hourly throughout the day. The dosages of GHRH used have been wide ranging, varying from 4 μg/kg/day to 50 μg/kg/day. Continuous infusion of GHRH has been shown to augment GH secretion in normal adults and GH deficient children without evidence of densensitization of the somatotrophs. Continuous SC infusion of GHRH has been shown to promote growth in short slowly growing children. Poor growth response to GHRH has been reported by some authors using daily SC injection while others reported significant growth acceleration in 42-87% of GH deficient children treated using different GHRH regimes. Although GH treatment in GH-deficient children results in more consistent growth acceleration, comparable growth response can be seen in some children treated with GHRH. The optimal mode of GHRH therapy remains to be determined, but it would appear that the growth response is dependent on the dose used and possibly on the frequency of administration. The development of a sustained release preparation of GHRH may prove to be an alternative to GH in the treatment of some Children with short stature.en_HK
dc.languageengen_HK
dc.publisherFreund Publishing House, Ltd. The Journal's web site is located at http://www.freundpublishing.com/Journal_Pediatric_Endocrinology_Metabolism/JPEMprev.htmen_HK
dc.relation.ispartofJournal of Pediatric Endocrinologyen_HK
dc.titleThe therapeutic use of growth-hormone-releasing hormoneen_HK
dc.typeArticleen_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8374684-
dc.identifier.scopuseid_2-s2.0-0027177087en_HK
dc.identifier.hkuros30215en_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spage15en_HK
dc.identifier.epage20en_HK
dc.identifier.isiWOS:A1993KM41800003-
dc.publisher.placeIsraelen_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK

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