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Article: Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese

TitleAssociation between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese
Authors
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
Citation
Genes And Immunity, 2007, v. 8 n. 6, p. 475-479 How to Cite?
AbstractChemokines play a major role in leukocyte recruitment during the formation of tuberculous granulomas. We studied the association between genetic polymorphisms of three chemokines, monocyte chemoattractant protein-1 (MCP-1), RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1α (MIP-1α), and tuberculosis (TB). The distribution of five functionally significant single-nucleotide polymorphisms (SNPs), MCP-1/ G, RANTES -403G/A, -28C/G and In1.1T/C as well as MIP-1α +459C/T was not found to be different between patients with TB and healthy control subjects of the Hong Kong Chinese population. However, differences in linkage disequilibrium (LD) of the SNPs of RANTES and in distribution of the haplotypes of RANTES between patients with TB and healthy controls (P < 0.0001) were found. Two risk haplotypes of RANTES, A-C-T and G-C-C, at positions -403, -28 and In1.1, respectively, were identified. Furthermore, combining the genotypes of RANTES -403 and In1.1, two diplotypes GA/TT (P < 0.001) and GG/TC (P < 0.0001) showed strong association with TB. Our findings support the association between RANTES functional polymorphisms and TB.
Persistent Identifierhttp://hdl.handle.net/10722/79859
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.636
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, SFen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorWong, HSen_HK
dc.contributor.authorKam, KMen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.date.accessioned2010-09-06T07:59:33Z-
dc.date.available2010-09-06T07:59:33Z-
dc.date.issued2007en_HK
dc.identifier.citationGenes And Immunity, 2007, v. 8 n. 6, p. 475-479en_HK
dc.identifier.issn1466-4879en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79859-
dc.description.abstractChemokines play a major role in leukocyte recruitment during the formation of tuberculous granulomas. We studied the association between genetic polymorphisms of three chemokines, monocyte chemoattractant protein-1 (MCP-1), RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1α (MIP-1α), and tuberculosis (TB). The distribution of five functionally significant single-nucleotide polymorphisms (SNPs), MCP-1/ G, RANTES -403G/A, -28C/G and In1.1T/C as well as MIP-1α +459C/T was not found to be different between patients with TB and healthy control subjects of the Hong Kong Chinese population. However, differences in linkage disequilibrium (LD) of the SNPs of RANTES and in distribution of the haplotypes of RANTES between patients with TB and healthy controls (P < 0.0001) were found. Two risk haplotypes of RANTES, A-C-T and G-C-C, at positions -403, -28 and In1.1, respectively, were identified. Furthermore, combining the genotypes of RANTES -403 and In1.1, two diplotypes GA/TT (P < 0.001) and GG/TC (P < 0.0001) showed strong association with TB. Our findings support the association between RANTES functional polymorphisms and TB.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/geneen_HK
dc.relation.ispartofGenes and Immunityen_HK
dc.titleAssociation between RANTES functional polymorphisms and tuberculosis in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1466-4879&volume=8&spage=475&epage=479&date=2007&atitle=Association+between+RANTES+functional+polymorphisms+and+tuberculosis+in+Hong+Kong+Chineseen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.gene.6364412en_HK
dc.identifier.pmid17625600-
dc.identifier.scopuseid_2-s2.0-34548403040en_HK
dc.identifier.hkuros138065en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548403040&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue6en_HK
dc.identifier.spage475en_HK
dc.identifier.epage479en_HK
dc.identifier.isiWOS:000249277300004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChu, SF=20733498700en_HK
dc.identifier.scopusauthoridTam, CM=7201442997en_HK
dc.identifier.scopusauthoridWong, HS=20736018600en_HK
dc.identifier.scopusauthoridKam, KM=7005354965en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.citeulike1454999-

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