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Article: Cytoglobin Overexpression Protects against Damage-Induced Fibrosis

TitleCytoglobin Overexpression Protects against Damage-Induced Fibrosis
Authors
Keywordscirrhosis
cytoglobin
fibrosis
hepatic stellate cells
hexacoordinate globin superfamily
liver damage
stellate cell activation associated protein
Issue Date2006
PublisherNature Publishing Group.
Citation
Molecular Therapy, 2006, v. 13 n. 6, p. 1093-1100 How to Cite?
AbstractCytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis. © 2006 The American Society of Gene Therapy.
Persistent Identifierhttp://hdl.handle.net/10722/79847
ISSN
2015 Impact Factor: 6.938
2015 SCImago Journal Rankings: 3.374
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Ren_HK
dc.contributor.authorHarrison, PMen_HK
dc.contributor.authorChen, Men_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorTsui, Tyen_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorCheung, Pten_HK
dc.contributor.authorWang, Gen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorDiao, Yen_HK
dc.contributor.authorKrissansen, GWen_HK
dc.contributor.authorXu, Sen_HK
dc.contributor.authorFarzaneh, Fen_HK
dc.date.accessioned2010-09-06T07:59:25Z-
dc.date.available2010-09-06T07:59:25Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular Therapy, 2006, v. 13 n. 6, p. 1093-1100en_HK
dc.identifier.issn1525-0016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79847-
dc.description.abstractCytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis. © 2006 The American Society of Gene Therapy.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group.en_HK
dc.relation.ispartofMolecular Therapyen_HK
dc.subjectcirrhosisen_HK
dc.subjectcytoglobinen_HK
dc.subjectfibrosisen_HK
dc.subjecthepatic stellate cellsen_HK
dc.subjecthexacoordinate globin superfamilyen_HK
dc.subjectliver damageen_HK
dc.subjectstellate cell activation associated proteinen_HK
dc.titleCytoglobin Overexpression Protects against Damage-Induced Fibrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1525-0016&volume=13&issue=6&spage=1093&epage=1100&date=2006&atitle=Cytoglobin+Overexpression+Protects+against+Damage-Induced+Fibrosisen_HK
dc.identifier.emailCheung, Pt:ptcheung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, Pt=rp00351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ymthe.2005.11.027en_HK
dc.identifier.pmid16581302-
dc.identifier.scopuseid_2-s2.0-33646888232en_HK
dc.identifier.hkuros127708en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646888232&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1093en_HK
dc.identifier.epage1100en_HK
dc.identifier.isiWOS:000238402000010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, R=7402813857en_HK
dc.identifier.scopusauthoridHarrison, PM=7401611975en_HK
dc.identifier.scopusauthoridChen, M=36831226400en_HK
dc.identifier.scopusauthoridLi, L=36831622600en_HK
dc.identifier.scopusauthoridTsui, Ty=7006622455en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridCheung, Pt=7202595465en_HK
dc.identifier.scopusauthoridWang, G=35211639800en_HK
dc.identifier.scopusauthoridLi, H=36078286800en_HK
dc.identifier.scopusauthoridDiao, Y=7004284714en_HK
dc.identifier.scopusauthoridKrissansen, GW=7004770042en_HK
dc.identifier.scopusauthoridXu, S=7404439649en_HK
dc.identifier.scopusauthoridFarzaneh, F=7006545549en_HK

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