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Article: A Pilot Study of the Use of Insulin Glargine in Combination with Short Acting Insulin Analogue in Adolescents with Type I Diabetes Mellitus in Hong Kong

TitleA Pilot Study of the Use of Insulin Glargine in Combination with Short Acting Insulin Analogue in Adolescents with Type I Diabetes Mellitus in Hong Kong
Authors
KeywordsAdolescents
Insulin glargine
Type I diabetes mellitus
Issue Date2004
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal of Paediatrics (New series), 2004, v. 9, p. 208-212 How to Cite?
AbstractThis pilot study is a retrospective analysis of the frequency of nocturnal hypoglycaemia and glycaemic control in 7 adolescents with well-controlled type I diabetes 3 to 6 months before and 6 months after switching to a new long-acting insulin analog-insulin glargine in combination with short acting insulin analogues before meals. The patients were on short acting insulin before the three main meals and isophane insulin at bedtime and they had a mean annual HbA1c value of 7.6±0.4%. The patients were switched to a new regime of insulin lispro before the three main meals and insulin glargine at bedtime. The mean duration of glargine treatment was 0.8?.3 years. The mean average fasting blood glucose determined by glucometer was significantly improved from 9.9±1.4 mmol/L to 8.5±1.2 mmol/L (p<0.05) after switching to insulin glargine. The proportion of morning blood glucose between 4 to 10 mmol/L achieved by patients significantly increased from 42.7±11.2% to 52.2±15.2% (p<0.05) without nocturnal or morning hypoglycaemia. There was no significant change in the daily insulin dosage between the two treatment regimes. This combination has a high degree of acceptability to motivated adolescent patients. A larger prospective study on the beneficial effects of insulin analogues on poorly controlled diabetes is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/79841
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorAu, RWM-
dc.contributor.authorKwan, EYW-
dc.contributor.authorYeung, LPK-
dc.contributor.authorCheung, PT-
dc.contributor.authorLow, LCK-
dc.date.accessioned2010-09-06T07:59:21Z-
dc.date.available2010-09-06T07:59:21Z-
dc.date.issued2004-
dc.identifier.citationHong Kong Journal of Paediatrics (New series), 2004, v. 9, p. 208-212-
dc.identifier.issn1013-9923-
dc.identifier.urihttp://hdl.handle.net/10722/79841-
dc.description.abstractThis pilot study is a retrospective analysis of the frequency of nocturnal hypoglycaemia and glycaemic control in 7 adolescents with well-controlled type I diabetes 3 to 6 months before and 6 months after switching to a new long-acting insulin analog-insulin glargine in combination with short acting insulin analogues before meals. The patients were on short acting insulin before the three main meals and isophane insulin at bedtime and they had a mean annual HbA1c value of 7.6±0.4%. The patients were switched to a new regime of insulin lispro before the three main meals and insulin glargine at bedtime. The mean duration of glargine treatment was 0.8?.3 years. The mean average fasting blood glucose determined by glucometer was significantly improved from 9.9±1.4 mmol/L to 8.5±1.2 mmol/L (p<0.05) after switching to insulin glargine. The proportion of morning blood glucose between 4 to 10 mmol/L achieved by patients significantly increased from 42.7±11.2% to 52.2±15.2% (p<0.05) without nocturnal or morning hypoglycaemia. There was no significant change in the daily insulin dosage between the two treatment regimes. This combination has a high degree of acceptability to motivated adolescent patients. A larger prospective study on the beneficial effects of insulin analogues on poorly controlled diabetes is warranted.-
dc.languageeng-
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp-
dc.relation.ispartofHong Kong Journal of Paediatrics (New series)-
dc.subjectAdolescents-
dc.subjectInsulin glargine-
dc.subjectType I diabetes mellitus-
dc.titleA Pilot Study of the Use of Insulin Glargine in Combination with Short Acting Insulin Analogue in Adolescents with Type I Diabetes Mellitus in Hong Kong-
dc.typeArticle-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=9&spage=208&epage=212&date=2004&atitle=A+Pilot+Study+of+the+Use+of+Insulin+Glargine+in+Combination+with+Short+Acting+Insulin+Analogue+in+Adolescents+with+Type+I+Diabetes+Mellitus+in+Hong+Kongen_HK
dc.identifier.emailKwan, EYW: eywkwan@HKUCC.hku.hk-
dc.identifier.emailCheung, PT: ptcheung@hkucc.hku.hk-
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hk-
dc.identifier.authorityCheung, PT=rp00351-
dc.identifier.authorityLow, LCK=rp00337-
dc.identifier.hkuros90197-
dc.identifier.volume9-
dc.identifier.spage208-
dc.identifier.epage212-
dc.publisher.placeHong Kong-

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