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Article: Clinical characteristics of chronic idiopathic thrombocytopenia in Chinese children

TitleClinical characteristics of chronic idiopathic thrombocytopenia in Chinese children
Authors
KeywordsChildren
Chinese
Chronic ITP
Thrombocytopenia
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpho-online.com
Citation
Journal Of Pediatric Hematology/Oncology, 2002, v. 24 n. 8, p. 648-652 How to Cite?
AbstractPurposes: Clinical course and treatment outcome of childhood chronic ITP are quite variable in the literature. We report in the current paper our observation on the clinical behavior of chronic ITP in Chinese children. Patients and Methods: We performed a retrospective review (Jan. 1990 to Dec. 2000) of children having low platelet count (plt < 150 × 109/L) for more than 6 months without identifiable cause. The indication for treatment was plt ≤ 20 × 109/L. Remission is defined as plt ≥ 150 × 109/L. Results: Thirty-four children were identified within these 11 years. Their median age at diagnosis was 6.7 years (range from 0.4 to 16.8 years). The M:F ratio was 16:18. Bone marrow aspiration was performed in 30/34 cases. The median plt count at presentation was 24 × 109/L (range 2 to 135 × 109/L). Fourteen of 34 (41%) children eventually achieved durable remission. The chance of remission at 5 years was 66.62% with a median follow-up time of 5.86 years (range 0.72 to 10.41 years). Concerning therapy, 17/34 (50%) required no treatment while for the remaining 17, treatment included steroid (n = 16), IVIG (n = 7) or splenectomy (n = 3). In spite of temporary improvement in most, treatment induced prolonged complete remission (plt > 150 × 109/L) in only 2 patients. Twenty of 31 tested had abnormal immune marker(s) at presentation but none evolved into specific autoimmune disease later on. There was no correlation between the remission status, response to treatment, and the presence of autoimmune markers. Conclusion: About half of our chronic ITP patients achieved remission within 5 years. Medical treatment does not seem to alter the natural course of the disease but induced a transient response in most cases. Positive autoimmune markers are common among chronic ITP patients and have no significance in predicting outcome.
Persistent Identifierhttp://hdl.handle.net/10722/79837
ISSN
2015 Impact Factor: 1.146
2015 SCImago Journal Rankings: 0.452
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, MSCen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:59:18Z-
dc.date.available2010-09-06T07:59:18Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Pediatric Hematology/Oncology, 2002, v. 24 n. 8, p. 648-652en_HK
dc.identifier.issn1077-4114en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79837-
dc.description.abstractPurposes: Clinical course and treatment outcome of childhood chronic ITP are quite variable in the literature. We report in the current paper our observation on the clinical behavior of chronic ITP in Chinese children. Patients and Methods: We performed a retrospective review (Jan. 1990 to Dec. 2000) of children having low platelet count (plt < 150 × 109/L) for more than 6 months without identifiable cause. The indication for treatment was plt ≤ 20 × 109/L. Remission is defined as plt ≥ 150 × 109/L. Results: Thirty-four children were identified within these 11 years. Their median age at diagnosis was 6.7 years (range from 0.4 to 16.8 years). The M:F ratio was 16:18. Bone marrow aspiration was performed in 30/34 cases. The median plt count at presentation was 24 × 109/L (range 2 to 135 × 109/L). Fourteen of 34 (41%) children eventually achieved durable remission. The chance of remission at 5 years was 66.62% with a median follow-up time of 5.86 years (range 0.72 to 10.41 years). Concerning therapy, 17/34 (50%) required no treatment while for the remaining 17, treatment included steroid (n = 16), IVIG (n = 7) or splenectomy (n = 3). In spite of temporary improvement in most, treatment induced prolonged complete remission (plt > 150 × 109/L) in only 2 patients. Twenty of 31 tested had abnormal immune marker(s) at presentation but none evolved into specific autoimmune disease later on. There was no correlation between the remission status, response to treatment, and the presence of autoimmune markers. Conclusion: About half of our chronic ITP patients achieved remission within 5 years. Medical treatment does not seem to alter the natural course of the disease but induced a transient response in most cases. Positive autoimmune markers are common among chronic ITP patients and have no significance in predicting outcome.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpho-online.comen_HK
dc.relation.ispartofJournal of Pediatric Hematology/Oncologyen_HK
dc.rightsJournal of Pediatric Hematology / Oncology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectChildrenen_HK
dc.subjectChineseen_HK
dc.subjectChronic ITPen_HK
dc.subjectThrombocytopeniaen_HK
dc.titleClinical characteristics of chronic idiopathic thrombocytopenia in Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1077-4114&volume=24&issue=8&spage=648&epage=652&date=2002&atitle=Clinical+characteristics+of+chronic+idiopathic+thrombocytopenia+in+Chinese+childrenen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00043426-200211000-00009en_HK
dc.identifier.pmid12439037-
dc.identifier.scopuseid_2-s2.0-0036842444en_HK
dc.identifier.hkuros75697en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036842444&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue8en_HK
dc.identifier.spage648en_HK
dc.identifier.epage652en_HK
dc.identifier.isiWOS:000179184300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, MSC=7403908239en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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