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Article: Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment

TitleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessment
Authors
Issue Date2008
PublisherInforma Healthcare. The Journal's web site is located at http://www.jcmr-online.com
Citation
Journal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1 How to Cite?
Abstract
Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/79834
ISSN
2013 Impact Factor: 5.112
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. Royal Brompton Hospital
  2. KK Women's And Children's Hospital
  3. The Children's Hospital of Philadelphia
  4. The University of Hong Kong
  5. National Heart Centre, Singapore
  6. Ege University Medical School
  7. Prince of Wales Hospital Hong Kong
  8. National Heart and Lung Institute
DC FieldValueLanguage
dc.contributor.authorHe, Ten_HK
dc.contributor.authorKirk, Pen_HK
dc.contributor.authorFirmin, DNen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorChu, WCWen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorTan, RSen_HK
dc.contributor.authorNg, Ien_HK
dc.contributor.authorBiceroglu, Sen_HK
dc.contributor.authorAydinok, Yen_HK
dc.contributor.authorFogel, MAen_HK
dc.contributor.authorCohen, ARen_HK
dc.contributor.authorPennell, DJen_HK
dc.date.accessioned2010-09-06T07:59:17Z-
dc.date.available2010-09-06T07:59:17Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1en_HK
dc.identifier.issn1097-6647en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79834-
dc.description.abstractBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.jcmr-online.comen_HK
dc.relation.ispartofJournal of Cardiovascular Magnetic Resonanceen_HK
dc.rightsJournal of Cardiovascular Magnetic Resonance. Copyright © Informa Healthcare.en_HK
dc.titleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1097-6647&volume=10&spage=11&epage=&date=2008&atitle=Multi-center+transferability+of+a+breath-hold+T2+technique+for+myocardial+iron+assessmenten_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1532-429X-10-11en_HK
dc.identifier.pmid18291040-
dc.identifier.pmcidPMC2279115-
dc.identifier.scopuseid_2-s2.0-44049090531en_HK
dc.identifier.hkuros142315en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44049090531&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.isiWOS:000257206500001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHe, T=34570131700en_HK
dc.identifier.scopusauthoridKirk, P=24474747700en_HK
dc.identifier.scopusauthoridFirmin, DN=7007100394en_HK
dc.identifier.scopusauthoridLam, WM=13410486800en_HK
dc.identifier.scopusauthoridChu, WCW=7402227871en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridTan, RS=7201984906en_HK
dc.identifier.scopusauthoridNg, I=46461891700en_HK
dc.identifier.scopusauthoridBiceroglu, S=8597590500en_HK
dc.identifier.scopusauthoridAydinok, Y=6701871501en_HK
dc.identifier.scopusauthoridFogel, MA=7102455134en_HK
dc.identifier.scopusauthoridCohen, AR=7404780851en_HK
dc.identifier.scopusauthoridPennell, DJ=7103221771en_HK

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