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Article: Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment
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TitleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessment
 
AuthorsHe, T8 1
Kirk, P8 1
Firmin, DN8 1
Lam, WM7
Chu, WCW7
Au, WY4
Chan, GCF4
Tan, RS5
Ng, I2
Biceroglu, S6
Aydinok, Y6
Fogel, MA3
Cohen, AR3
Pennell, DJ8 1
 
Issue Date2008
 
PublisherInforma Healthcare. The Journal's web site is located at http://www.jcmr-online.com
 
CitationJournal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1532-429X-10-11
 
AbstractBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
 
ISSN1097-6647
2013 Impact Factor: 5.112
 
DOIhttp://dx.doi.org/10.1186/1532-429X-10-11
 
PubMed Central IDPMC2279115
 
ISI Accession Number IDWOS:000257206500001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHe, T
 
dc.contributor.authorKirk, P
 
dc.contributor.authorFirmin, DN
 
dc.contributor.authorLam, WM
 
dc.contributor.authorChu, WCW
 
dc.contributor.authorAu, WY
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorTan, RS
 
dc.contributor.authorNg, I
 
dc.contributor.authorBiceroglu, S
 
dc.contributor.authorAydinok, Y
 
dc.contributor.authorFogel, MA
 
dc.contributor.authorCohen, AR
 
dc.contributor.authorPennell, DJ
 
dc.date.accessioned2010-09-06T07:59:17Z
 
dc.date.available2010-09-06T07:59:17Z
 
dc.date.issued2008
 
dc.description.abstractBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1532-429X-10-11
 
dc.identifier.doihttp://dx.doi.org/10.1186/1532-429X-10-11
 
dc.identifier.hkuros142315
 
dc.identifier.isiWOS:000257206500001
 
dc.identifier.issn1097-6647
2013 Impact Factor: 5.112
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2279115
 
dc.identifier.pmid18291040
 
dc.identifier.scopuseid_2-s2.0-44049090531
 
dc.identifier.urihttp://hdl.handle.net/10722/79834
 
dc.identifier.volume10
 
dc.languageeng
 
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.jcmr-online.com
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Cardiovascular Magnetic Resonance
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Cardiovascular Magnetic Resonance. Copyright © Informa Healthcare.
 
dc.titleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessment
 
dc.typeArticle
 
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<description.abstract>Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. &#169; 2008 Pennell; licensee BioMed Central Ltd.</description.abstract>
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Author Affiliations
  1. Royal Brompton Hospital
  2. KK Women's And Children's Hospital
  3. The Children's Hospital of Philadelphia
  4. The University of Hong Kong
  5. National Heart Centre, Singapore
  6. Ege University Medical School
  7. Prince of Wales Hospital Hong Kong
  8. National Heart and Lung Institute