Article: Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment

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TitleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessment
AuthorsHe, T1 8
Kirk, P1 8
Firmin, DN1 8
Lam, WM7
Chu, WCW7
Au, WY4
Chan, GCF4
Tan, RS5
Ng, I2
Biceroglu, S6
Aydinok, Y6
Fogel, MA3
Cohen, AR3
Pennell, DJ1 8
Issue Date2008
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10976647.asp
CitationJournal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1532-429X-10-11
AbstractBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
ISSN1097-6647
2011 Impact Factor: 3.717
2011 SCImago Journal Rankings: 0.270
DOIhttp://dx.doi.org/10.1186/1532-429X-10-11
ISI Accession Number IDWOS:000257206500001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHe, T
dc.contributor.authorKirk, P
dc.contributor.authorFirmin, DN
dc.contributor.authorLam, WM
dc.contributor.authorChu, WCW
dc.contributor.authorAu, WY
dc.contributor.authorChan, GCF
dc.contributor.authorTan, RS
dc.contributor.authorNg, I
dc.contributor.authorBiceroglu, S
dc.contributor.authorAydinok, Y
dc.contributor.authorFogel, MA
dc.contributor.authorCohen, AR
dc.contributor.authorPennell, DJ
dc.date.accessioned2010-09-06T07:59:17Z
dc.date.available2010-09-06T07:59:17Z
dc.date.issued2008
dc.description.abstractBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Cardiovascular Magnetic Resonance, 2008, v. 10 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1532-429X-10-11
dc.identifier.doihttp://dx.doi.org/10.1186/1532-429X-10-11
dc.identifier.hkuros142315
dc.identifier.isiWOS:000257206500001
dc.identifier.issn1097-6647
2011 Impact Factor: 3.717
2011 SCImago Journal Rankings: 0.270
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-44049090531
dc.identifier.urihttp://hdl.handle.net/10722/79834
dc.identifier.volume10
dc.languageeng
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10976647.asp
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Cardiovascular Magnetic Resonance
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Cardiovascular Magnetic Resonance. Copyright © Informa Healthcare.
dc.titleMulti-center transferability of a breath-hold T2 technique for myocardial iron assessment
dc.typeArticle
Author Affiliations
  1. Royal Brompton Hospital
  2. KK Women's And Children's Hospital
  3. The Children's Hospital of Philadelphia
  4. The University of Hong Kong
  5. National Heart Centre, Singapore
  6. Ege University Medical School
  7. Prince of Wales Hospital Hong Kong
  8. National Heart and Lung Institute