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Article: Children and adolescents with haemophilia in Hong Kong: An epidemiological and clinical review

TitleChildren and adolescents with haemophilia in Hong Kong: An epidemiological and clinical review
Authors
KeywordsChildren and adolescents
Clinical status
Epidemiology
Haemophilia
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 13-19 How to Cite?
AbstractA survey was performed in late-2003 by questionnaire to all paediatric and adolescent departments under the Hospital Authority of Hong Kong to study the epidemiology and clinical status of local haemophilia patients under 19 years of age. A total of 90 patients were recruited, corresponding to a local prevalence of 6.4 per 100,000. Among these 90 patients, 83.3% were haemophilia A and 16.7% were haemophilia B cases. Maternal carrier status was uncertain in 44.6% of patients and genotypic assessment was not performed in most of these cases. None had received primary prophylaxis although 42.9% of them were severe haemophiliacs and 46.4% had already suffered from chronic arthropathy. Inhibitors were detected only in 8.1% of patients. None was infected with human immunodeficiency virus but hepatitis C antibody was detected in 12 and hepatitis B surface antigen was positive in two patients. All but one of the infected patients were older than 13 years with only one patient suffering from chronic hepatitis. Twelve patients had history of intra-cranial haemorrhage. While infective complications were uncommon in our young haemophilia patients, improvement in carrier detection, prevention and treatment of haemophilic arthropathy should be considered in the future development of local haemophilia care.
Persistent Identifierhttp://hdl.handle.net/10722/79801
ISSN
2014 Impact Factor: 0.133
2014 SCImago Journal Rankings: 0.126
References

 

DC FieldValueLanguage
dc.contributor.authorLing, SCen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorShing, MMKen_HK
dc.contributor.authorYuen, HLen_HK
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorChan, CWen_HK
dc.contributor.authorLee, CYen_HK
dc.contributor.authorKwong, KSen_HK
dc.contributor.authorLi, CKen_HK
dc.date.accessioned2010-09-06T07:58:54Z-
dc.date.available2010-09-06T07:58:54Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 13-19en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79801-
dc.description.abstractA survey was performed in late-2003 by questionnaire to all paediatric and adolescent departments under the Hospital Authority of Hong Kong to study the epidemiology and clinical status of local haemophilia patients under 19 years of age. A total of 90 patients were recruited, corresponding to a local prevalence of 6.4 per 100,000. Among these 90 patients, 83.3% were haemophilia A and 16.7% were haemophilia B cases. Maternal carrier status was uncertain in 44.6% of patients and genotypic assessment was not performed in most of these cases. None had received primary prophylaxis although 42.9% of them were severe haemophiliacs and 46.4% had already suffered from chronic arthropathy. Inhibitors were detected only in 8.1% of patients. None was infected with human immunodeficiency virus but hepatitis C antibody was detected in 12 and hepatitis B surface antigen was positive in two patients. All but one of the infected patients were older than 13 years with only one patient suffering from chronic hepatitis. Twelve patients had history of intra-cranial haemorrhage. While infective complications were uncommon in our young haemophilia patients, improvement in carrier detection, prevention and treatment of haemophilic arthropathy should be considered in the future development of local haemophilia care.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectChildren and adolescentsen_HK
dc.subjectClinical statusen_HK
dc.subjectEpidemiologyen_HK
dc.subjectHaemophiliaen_HK
dc.titleChildren and adolescents with haemophilia in Hong Kong: An epidemiological and clinical reviewen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=13&epage=19&date=2006&atitle=Children+and+Adolescents+with+Haemophilia+in+Hong+Kong:+An+Epidemiological+and+Clinical+Reviewen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-31344452904en_HK
dc.identifier.hkuros114549en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344452904&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage19en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLing, SC=7102701299en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridShing, MMK=7006423846en_HK
dc.identifier.scopusauthoridYuen, HL=7103253677en_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridChan, CW=34979931400en_HK
dc.identifier.scopusauthoridLee, CY=9845762500en_HK
dc.identifier.scopusauthoridKwong, KS=36943196800en_HK
dc.identifier.scopusauthoridLi, CK=15122650100en_HK

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