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Article: Children and adolescents with haemophilia in Hong Kong: An epidemiological and clinical review
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TitleChildren and adolescents with haemophilia in Hong Kong: An epidemiological and clinical review
 
AuthorsLing, SC2
Chan, GCF7
Shing, MMK5
Yuen, HL4
Lee, ACW3
Chan, CW6
Lee, CY8
Kwong, KS1
Li, CK5
 
KeywordsChildren and adolescents
Clinical status
Epidemiology
Haemophilia
 
Issue Date2006
 
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
CitationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 13-19 [How to Cite?]
 
AbstractA survey was performed in late-2003 by questionnaire to all paediatric and adolescent departments under the Hospital Authority of Hong Kong to study the epidemiology and clinical status of local haemophilia patients under 19 years of age. A total of 90 patients were recruited, corresponding to a local prevalence of 6.4 per 100,000. Among these 90 patients, 83.3% were haemophilia A and 16.7% were haemophilia B cases. Maternal carrier status was uncertain in 44.6% of patients and genotypic assessment was not performed in most of these cases. None had received primary prophylaxis although 42.9% of them were severe haemophiliacs and 46.4% had already suffered from chronic arthropathy. Inhibitors were detected only in 8.1% of patients. None was infected with human immunodeficiency virus but hepatitis C antibody was detected in 12 and hepatitis B surface antigen was positive in two patients. All but one of the infected patients were older than 13 years with only one patient suffering from chronic hepatitis. Twelve patients had history of intra-cranial haemorrhage. While infective complications were uncommon in our young haemophilia patients, improvement in carrier detection, prevention and treatment of haemophilic arthropathy should be considered in the future development of local haemophilia care.
 
ISSN1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLing, SC
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorShing, MMK
 
dc.contributor.authorYuen, HL
 
dc.contributor.authorLee, ACW
 
dc.contributor.authorChan, CW
 
dc.contributor.authorLee, CY
 
dc.contributor.authorKwong, KS
 
dc.contributor.authorLi, CK
 
dc.date.accessioned2010-09-06T07:58:54Z
 
dc.date.available2010-09-06T07:58:54Z
 
dc.date.issued2006
 
dc.description.abstractA survey was performed in late-2003 by questionnaire to all paediatric and adolescent departments under the Hospital Authority of Hong Kong to study the epidemiology and clinical status of local haemophilia patients under 19 years of age. A total of 90 patients were recruited, corresponding to a local prevalence of 6.4 per 100,000. Among these 90 patients, 83.3% were haemophilia A and 16.7% were haemophilia B cases. Maternal carrier status was uncertain in 44.6% of patients and genotypic assessment was not performed in most of these cases. None had received primary prophylaxis although 42.9% of them were severe haemophiliacs and 46.4% had already suffered from chronic arthropathy. Inhibitors were detected only in 8.1% of patients. None was infected with human immunodeficiency virus but hepatitis C antibody was detected in 12 and hepatitis B surface antigen was positive in two patients. All but one of the infected patients were older than 13 years with only one patient suffering from chronic hepatitis. Twelve patients had history of intra-cranial haemorrhage. While infective complications were uncommon in our young haemophilia patients, improvement in carrier detection, prevention and treatment of haemophilic arthropathy should be considered in the future development of local haemophilia care.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 13-19 [How to Cite?]
 
dc.identifier.epage19
 
dc.identifier.hkuros114549
 
dc.identifier.issn1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-31344452904
 
dc.identifier.spage13
 
dc.identifier.urihttp://hdl.handle.net/10722/79801
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Journal of Paediatrics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectChildren and adolescents
 
dc.subjectClinical status
 
dc.subjectEpidemiology
 
dc.subjectHaemophilia
 
dc.titleChildren and adolescents with haemophilia in Hong Kong: An epidemiological and clinical review
 
dc.typeArticle
 
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<contributor.author>Yuen, HL</contributor.author>
<contributor.author>Lee, ACW</contributor.author>
<contributor.author>Chan, CW</contributor.author>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Prince of Wales Hospital Hong Kong
  6. United Christian Hospital Hong Kong
  7. Queen Mary Hospital Hong Kong
  8. Caritas Medical Centre Hong Kong