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Article: Neuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus

TitleNeuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosus
Authors
Issue Date2008
PublisherAmerican Academy of Pediatrics.
Citation
Pediatrics, 2008, v. 121 n. S2, p. S161-S162 How to Cite?
AbstractINTRODUCTION: There is a paucity of clinical studies on children with neuropsychiatric systemic lupus erythematosus (NPSLE). OBJECTIVE: The objective of this study was to define the clinical characteristics of and the potential predictors for NPSLE in Chinese children. METHODS: Sixty-two children with SLE diagnosed between 1990 and 2006 were retrospectively reviewed. Patients were evaluated according to the American College of Rheumatology case definitions (1999) for classification of neuropsychiatric symptoms. The demographic data, clinical manifestations, laboratory parameters (complete blood count, erythrocyte sedimentation rate, C-reactive protein, complement levels, anti-cardiolipin antibodies, and autoimmune markers), treatment, and SLE disease activity index score were analyzed. RESULTS: Nineteen (30.65%) patients with SLE and 21 neuropsychiatric events were identified. Mean age at NPSLE manifestations was 13.57 ± 4.33 years. The most common neuropsychiatric manifestations were cognitive dysfunction (47.62%), seizure disorder (42.86%), and headache (28.57%), followed by mood disorder (19.05%), myelopathy (19.05%), cerebrovascular disease (14.29%), psychosis (9.52%), cranial neuropathy (9.52%), and mononeuropathy multiplex (4.76%). Renal involvement at diagnosis of SLE was significantly less common in patients with NPSLE than in those with non-NPSLE. Apart from that, we could not identify other clinical or laboratory parameters that could predict the development of NPSLE. Six patients presented with neuropsychiatric symptoms at onset of SLE. Comparing them with patients with later neuropsychiatric development, their mean age was younger and the SLE disease activity index score was significantly higher. CONCLUSIONS: Neuropsychiatric symptoms were common in Chinese children with SLE. Early-onset NPSLE occurred in younger patients with higher disease activity score. Neuropsychiatric development was negatively associated with renal involvement at diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/79796
ISSN
2015 Impact Factor: 5.196
2015 SCImago Journal Rankings: 3.226

 

DC FieldValueLanguage
dc.contributor.authorLau, YLen_HK
dc.contributor.authorDong, Jen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorWong, WHSen_HK
dc.date.accessioned2010-09-06T07:58:51Z-
dc.date.available2010-09-06T07:58:51Z-
dc.date.issued2008en_HK
dc.identifier.citationPediatrics, 2008, v. 121 n. S2, p. S161-S162en_HK
dc.identifier.issn0031-4005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79796-
dc.description.abstractINTRODUCTION: There is a paucity of clinical studies on children with neuropsychiatric systemic lupus erythematosus (NPSLE). OBJECTIVE: The objective of this study was to define the clinical characteristics of and the potential predictors for NPSLE in Chinese children. METHODS: Sixty-two children with SLE diagnosed between 1990 and 2006 were retrospectively reviewed. Patients were evaluated according to the American College of Rheumatology case definitions (1999) for classification of neuropsychiatric symptoms. The demographic data, clinical manifestations, laboratory parameters (complete blood count, erythrocyte sedimentation rate, C-reactive protein, complement levels, anti-cardiolipin antibodies, and autoimmune markers), treatment, and SLE disease activity index score were analyzed. RESULTS: Nineteen (30.65%) patients with SLE and 21 neuropsychiatric events were identified. Mean age at NPSLE manifestations was 13.57 ± 4.33 years. The most common neuropsychiatric manifestations were cognitive dysfunction (47.62%), seizure disorder (42.86%), and headache (28.57%), followed by mood disorder (19.05%), myelopathy (19.05%), cerebrovascular disease (14.29%), psychosis (9.52%), cranial neuropathy (9.52%), and mononeuropathy multiplex (4.76%). Renal involvement at diagnosis of SLE was significantly less common in patients with NPSLE than in those with non-NPSLE. Apart from that, we could not identify other clinical or laboratory parameters that could predict the development of NPSLE. Six patients presented with neuropsychiatric symptoms at onset of SLE. Comparing them with patients with later neuropsychiatric development, their mean age was younger and the SLE disease activity index score was significantly higher. CONCLUSIONS: Neuropsychiatric symptoms were common in Chinese children with SLE. Early-onset NPSLE occurred in younger patients with higher disease activity score. Neuropsychiatric development was negatively associated with renal involvement at diagnosis.-
dc.languageengen_HK
dc.publisherAmerican Academy of Pediatrics.en_HK
dc.relation.ispartofPediatricsen_HK
dc.titleNeuropsychiatric Symptoms in Chinese Children with Systemic Lupus Erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1120-7507&volume=121&spage=S161&epage=2&date=2008&atitle=Neuropsychiatric+Symptoms+in+Chinese+Children+with+Systemic+Lupus+Erythematosusen_HK
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hken_HK
dc.identifier.emailLee, TL: leetsz@HKUCC.hku.hken_HK
dc.identifier.emailLee, PPW: ppwlee@hku.hken_HK
dc.identifier.emailHo, MHK: marcoho@HKUCC.hku.hken_HK
dc.identifier.emailWong, WHS: whswong@hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1542/peds.2007-2022LLLLLLL-
dc.identifier.hkuros142532en_HK

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