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Conference Paper: Computer simulation of final height after growth-promoting therapy

TitleComputer simulation of final height after growth-promoting therapy
Authors
KeywordsChildren
Final height
Growth response
Height prediction
Issue Date1996
PublisherTaylor & Francis Ltd.
Citation
The 21st International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism, Venice, 19-20 April 1996. In Acta Paediatrica, Supplement, 1996, v. 85 n. 417, p. 61-63 How to Cite?
AbstractThis short communication discusses the possible influence of final height prediction on the estimation of the growth response to therapy. These influences are illustrated in terms of height at 8 and 18 years of age for 28 prepubertally short boys. On the basis of several treatment simulations and assumptions, we conclude that the mean residual final height; that is, the mean of individual differences between final height and predicted final height, is a robust outcome measure in growth-promoting studies. However, the treatment residual final height (the difference between final height and predicted final height following growth-promoting treatment) was only partially correlated (r2 = 0.27) with the gain due to treatment, but was highly correlated (r2 = 0.75) with the residual final height; thus, growth-response estimations made on the basis of treatment residual final height may be more dependent on the predicted interval, or confidence interval, of final height than on the effect of growth-promoting treatment.
Persistent Identifierhttp://hdl.handle.net/10722/79790
ISSN
2014 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorKarlberg, Jen_HK
dc.date.accessioned2010-09-06T07:58:46Z-
dc.date.available2010-09-06T07:58:46Z-
dc.date.issued1996en_HK
dc.identifier.citationThe 21st International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism, Venice, 19-20 April 1996. In Acta Paediatrica, Supplement, 1996, v. 85 n. 417, p. 61-63en_HK
dc.identifier.issn0803-5326en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79790-
dc.description.abstractThis short communication discusses the possible influence of final height prediction on the estimation of the growth response to therapy. These influences are illustrated in terms of height at 8 and 18 years of age for 28 prepubertally short boys. On the basis of several treatment simulations and assumptions, we conclude that the mean residual final height; that is, the mean of individual differences between final height and predicted final height, is a robust outcome measure in growth-promoting studies. However, the treatment residual final height (the difference between final height and predicted final height following growth-promoting treatment) was only partially correlated (r2 = 0.27) with the gain due to treatment, but was highly correlated (r2 = 0.75) with the residual final height; thus, growth-response estimations made on the basis of treatment residual final height may be more dependent on the predicted interval, or confidence interval, of final height than on the effect of growth-promoting treatment.en_HK
dc.languageengen_HK
dc.publisherTaylor & Francis Ltd.en_HK
dc.relation.ispartofActa Paediatrica, Supplementen_HK
dc.subjectChildrenen_HK
dc.subjectFinal heighten_HK
dc.subjectGrowth responseen_HK
dc.subjectHeight predictionen_HK
dc.titleComputer simulation of final height after growth-promoting therapyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0803-5326&volume=417&spage=61&epage=63&date=1996&atitle=Computer+simulation+of+final+height+after+growth-promoting+therapyen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1651-2227.1996.tb14299.x-
dc.identifier.scopuseid_2-s2.0-0030498745en_HK
dc.identifier.hkuros21542en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030498745&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue417en_HK
dc.identifier.spage61en_HK
dc.identifier.epage63en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.description.otherThe 21st International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism, Venice, 19-20 April 1996. In Acta Paediatrica, Supplement, 1996, v. 85 n. 417, p. 61-63-
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.customcontrol.immutablecsl 160516-

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