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Article: Epstein-Barr virus-associated infectious mononucleosis in Chinese children

TitleEpstein-Barr virus-associated infectious mononucleosis in Chinese children
Authors
KeywordsChinese children
Epstein-Barr virus
Infectious mononucleosis
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.com
Citation
Pediatric Infectious Disease Journal, 2003, v. 22 n. 11, p. 974-978 How to Cite?
AbstractBackground. According to seroprevalence studies the majority of children in Hong Kong are infected by Epstein-Barr virus (EBV) before 10 years of age, but the characteristics of EBV-associated infectious mononucleosis (IM) in Chinese children are largely unreported. This study aims at defining the clinical presentation and complications of Chinese childhood IM in relation to age of the children. Methods. A retrospective study was performed on 77 consecutive Chinese childhood IM patients who fulfilled the serologic criteria for the diagnosis of primary EBV infection (viral capsid antigen IgM + viral capsid antigen IgG+ Epstein-Barr nuclear antigen-). The clinical, hematologic and biochemical findings were evaluated among four age groups of <2 years, 2 to 4 years, 5 to 9 years and 10 to 15 years. Results and conclusions. EBV-associated IM occurred at all age groups with a peak incidence at 2 to 4 years, corresponding to the rapid rise in the seroprevalence of EBV in early childhood in the Hong Kong Chinese. The majority of children presented with fever, tonsillopharyngitis, lymphadenopathy and hepatosplenomegaly, similar to the adult IM patients, and recovered without major complications. Marked lymphocytosis with the presence of atypical lymphocytes was a consistent hematologic finding in all age groups. The occurrence of hepatitis showed a clear association with advancing age (P = 0.003). The age-related increase in IM-associated hepatitis may reflect difference in the host immune response against EBV between the infants and older children.
Persistent Identifierhttp://hdl.handle.net/10722/79788
ISSN
2015 Impact Factor: 2.587
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CWen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorLau, ASYen_HK
dc.date.accessioned2010-09-06T07:58:44Z-
dc.date.available2010-09-06T07:58:44Z-
dc.date.issued2003en_HK
dc.identifier.citationPediatric Infectious Disease Journal, 2003, v. 22 n. 11, p. 974-978en_HK
dc.identifier.issn0891-3668en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79788-
dc.description.abstractBackground. According to seroprevalence studies the majority of children in Hong Kong are infected by Epstein-Barr virus (EBV) before 10 years of age, but the characteristics of EBV-associated infectious mononucleosis (IM) in Chinese children are largely unreported. This study aims at defining the clinical presentation and complications of Chinese childhood IM in relation to age of the children. Methods. A retrospective study was performed on 77 consecutive Chinese childhood IM patients who fulfilled the serologic criteria for the diagnosis of primary EBV infection (viral capsid antigen IgM + viral capsid antigen IgG+ Epstein-Barr nuclear antigen-). The clinical, hematologic and biochemical findings were evaluated among four age groups of <2 years, 2 to 4 years, 5 to 9 years and 10 to 15 years. Results and conclusions. EBV-associated IM occurred at all age groups with a peak incidence at 2 to 4 years, corresponding to the rapid rise in the seroprevalence of EBV in early childhood in the Hong Kong Chinese. The majority of children presented with fever, tonsillopharyngitis, lymphadenopathy and hepatosplenomegaly, similar to the adult IM patients, and recovered without major complications. Marked lymphocytosis with the presence of atypical lymphocytes was a consistent hematologic finding in all age groups. The occurrence of hepatitis showed a clear association with advancing age (P = 0.003). The age-related increase in IM-associated hepatitis may reflect difference in the host immune response against EBV between the infants and older children.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.comen_HK
dc.relation.ispartofPediatric Infectious Disease Journalen_HK
dc.rightsThe Pediatric Infectious Disease Journal. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectChinese childrenen_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectInfectious mononucleosisen_HK
dc.titleEpstein-Barr virus-associated infectious mononucleosis in Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-3668&volume=22&issue=11&spage=974&epage=978&date=2003&atitle=Epstein-Barr+virus-associated+infectious+mononucleosis+in+Chinese+childrenen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, ASY:asylau@hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.inf.0000095199.56025.96en_HK
dc.identifier.pmid14614370-
dc.identifier.scopuseid_2-s2.0-0344413631en_HK
dc.identifier.hkuros85148en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344413631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue11en_HK
dc.identifier.spage974en_HK
dc.identifier.epage978en_HK
dc.identifier.isiWOS:000186622200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, CW=34979931400en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK

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