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Article: Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT

TitleQuality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2008, v. 42 n. 5, p. 319-327 How to Cite?
AbstractIn this cross-sectional study, we compared the quality of life (QOL) in transfusion-dependent thalassemic patients who survived matched sibling hematopoietic SCT (HSCT, n = 24) with patients treated conventionally with transfusion and iron chelation (n = 74). WHOQOL-BREF(HK) and PedsQL questionnaires were administered to patients aged >18 years and 5-12 years, respectively. Patients aged 12-18 years received both questionnaires. WHOQOL-BREF(HK) revealed post transplant patients rated overall health better than those treated conventionally (score 3.67 vs 3.06, P = 0.01). They are less dependent on medical aids (3.87 vs 2.96, P = 0.006), having higher activity level (4.00 vs 3.36, P = 0.026) and better personal relationships (4.13 vs 3.69, P = 0.014). Physical health domain score was better (75.20 vs 63.94, P = 0.007). These differences remained significant after adjustment for comorbidities. PedsQL revealed post transplant patients rated better for running (3.53 vs 2.72, P = 0.001) and sports (3.20 vs 2.64, P = 0.038), even after adjustment for comorbidities, but were less satisfied for school absence to attend hospital (2.53 vs 3.29, P = 0.03). Post transplant patients were significantly more likely to consider marriage (100 vs 75.7%, P = 0.033), but not childbearing (66.7 vs 51.4%, P = 0.28). In conclusion, transplanted thalassemic patients enjoy better QOL, mainly in physical health, compared with conventionally treated patients. This information is important to patients considering HSCT.
Persistent Identifierhttp://hdl.handle.net/10722/79775
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Children's Thalassemia Foundation
Funding Information:

This project was supported by research fund from Hong Kong Children's Thalassemia Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorMok, ASPen_HK
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-06T07:58:35Z-
dc.date.available2010-09-06T07:58:35Z-
dc.date.issued2008en_HK
dc.identifier.citationBone Marrow Transplantation, 2008, v. 42 n. 5, p. 319-327en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79775-
dc.description.abstractIn this cross-sectional study, we compared the quality of life (QOL) in transfusion-dependent thalassemic patients who survived matched sibling hematopoietic SCT (HSCT, n = 24) with patients treated conventionally with transfusion and iron chelation (n = 74). WHOQOL-BREF(HK) and PedsQL questionnaires were administered to patients aged >18 years and 5-12 years, respectively. Patients aged 12-18 years received both questionnaires. WHOQOL-BREF(HK) revealed post transplant patients rated overall health better than those treated conventionally (score 3.67 vs 3.06, P = 0.01). They are less dependent on medical aids (3.87 vs 2.96, P = 0.006), having higher activity level (4.00 vs 3.36, P = 0.026) and better personal relationships (4.13 vs 3.69, P = 0.014). Physical health domain score was better (75.20 vs 63.94, P = 0.007). These differences remained significant after adjustment for comorbidities. PedsQL revealed post transplant patients rated better for running (3.53 vs 2.72, P = 0.001) and sports (3.20 vs 2.64, P = 0.038), even after adjustment for comorbidities, but were less satisfied for school absence to attend hospital (2.53 vs 3.29, P = 0.03). Post transplant patients were significantly more likely to consider marriage (100 vs 75.7%, P = 0.033), but not childbearing (66.7 vs 51.4%, P = 0.28). In conclusion, transplanted thalassemic patients enjoy better QOL, mainly in physical health, compared with conventionally treated patients. This information is important to patients considering HSCT.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshQuality of Life-
dc.subject.meshQuestionnaires-
dc.subject.meshThalassemia - therapy-
dc.subject.meshTransplantation, Homologous-
dc.titleQuality of life in patients with transfusion-dependent thalassemia after hematopoietic SCTen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=42&issue=5&spage=319&epage=327&date=2008&atitle=Quality+of+life+in+patients+with+transfusion-dependent+thalassemia+after+hematopoietic+SCTen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/bmt.2008.165en_HK
dc.identifier.pmid18560410-
dc.identifier.scopuseid_2-s2.0-52149111377en_HK
dc.identifier.hkuros145677en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52149111377&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue5en_HK
dc.identifier.spage319en_HK
dc.identifier.epage327en_HK
dc.identifier.isiWOS:000259061600003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridMok, ASP=24470317700en_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.citeulike2899091-

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