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Article: Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response

TitleMechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response
Authors
KeywordsCytokines
HIV Tat protein
HIV-1
Protein kinase PKR
Transcription factors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2005, v. 579 n. 14, p. 3055-3062 How to Cite?
AbstractHIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79768
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, JCBen_HK
dc.contributor.authorLee, DCWen_HK
dc.contributor.authorCheung, BKWen_HK
dc.contributor.authorLau, ASYen_HK
dc.date.accessioned2010-09-06T07:58:29Z-
dc.date.available2010-09-06T07:58:29Z-
dc.date.issued2005en_HK
dc.identifier.citationFebs Letters, 2005, v. 579 n. 14, p. 3055-3062en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79768-
dc.description.abstractHIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.en_HK
dc.subjectCytokinesen_HK
dc.subjectHIV Tat proteinen_HK
dc.subjectHIV-1en_HK
dc.subjectProtein kinase PKRen_HK
dc.subjectTranscription factorsen_HK
dc.titleMechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune responseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-5793&volume=579&spage=3055&epage=3062&date=2005&atitle=Mechanisms+for+HIV+Tat+upregulation+of+IL-10+and+other+cytokine+expression:+kinase+signaling+and+PKR-mediated+immune+response.en_HK
dc.identifier.emailLi, JCB: jamesli@hku.hken_HK
dc.identifier.emailLau, ASY: asylau@hku.hken_HK
dc.identifier.authorityLi, JCB=rp00496en_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2005.04.060en_HK
dc.identifier.pmid15907845-
dc.identifier.scopuseid_2-s2.0-20444422574en_HK
dc.identifier.hkuros105921en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444422574&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume579en_HK
dc.identifier.issue14en_HK
dc.identifier.spage3055en_HK
dc.identifier.epage3062en_HK
dc.identifier.isiWOS:000229822500015-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLi, JCB=23103447500en_HK
dc.identifier.scopusauthoridLee, DCW=15751156000en_HK
dc.identifier.scopusauthoridCheung, BKW=9634391200en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK

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