File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A partial transient effect of short-term growth hormone (GH) treatment in short non-GH deficient prepubertal children

TitleA partial transient effect of short-term growth hormone (GH) treatment in short non-GH deficient prepubertal children
Authors
KeywordsCatch-down growth posttreatment
non-GH deficient
Issue Date1995
PublisherFreund Publishing House, Ltd. The Journal's web site is located at http://www.freundpublishing.com/Journal_Pediatric_Endocrinology_Metabolism/JPEMprev.htm
Citation
Journal Of Pediatric Endocrinology And Metabolism, 1995, v. 8 n. 3, p. 173-179 How to Cite?
AbstractThis study reports the growth of 11 short non-GH deficient children before, during short-term GH therapy for 1 year and for 2 years after the cessation of treatment. The mean growth velocity increased significantly (p < 0.0001) from the pretreatment mean of 4,6 (SD = 0.95) cm/year to 8.4 (SD = 1.1) cm/year after 1 year of GH treatment without accelerated advancement of skeletal maturation. The serum IGF-1 levels also increased significantly with treatment. In nine children-who remained prepubertal followed for one year after GH treatment, the mean growth velocity increased from 4.5 (SD = 0.69) cm/year before treatment to 8.7 (SD = 1.28) cm/year after 1 year of GH treatment (p < 0.0001). After stopping GH treatment, the growth velocity decreased significantly (p < 0.001) to 2.4 (SD = 0.68) cm/year during the first year of follow-up. In the six prepubertal children followed up for 2 years after treatment, the mean growth velocity was 4.1. (SD = 1.04) cm/ year which was not significantly different from the pretreatment growth velocity. The significant decrease in growth velocity during the first post-treatment year could not be explained by the usual fall of growth velocity with increasing age in prepubertal children. Our results indicate that the effect of one year of GH treatment on height gain is partly transient and cast doubt on the efficacy of short-term GH therapy in short non-GH deficient patients.
Persistent Identifierhttp://hdl.handle.net/10722/79758
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.493
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLow, LCKen_HK
dc.contributor.authorKwan, Een_HK
dc.contributor.authorKarlberg, Jen_HK
dc.date.accessioned2010-09-06T07:58:22Z-
dc.date.available2010-09-06T07:58:22Z-
dc.date.issued1995en_HK
dc.identifier.citationJournal Of Pediatric Endocrinology And Metabolism, 1995, v. 8 n. 3, p. 173-179en_HK
dc.identifier.issn0334-018Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79758-
dc.description.abstractThis study reports the growth of 11 short non-GH deficient children before, during short-term GH therapy for 1 year and for 2 years after the cessation of treatment. The mean growth velocity increased significantly (p < 0.0001) from the pretreatment mean of 4,6 (SD = 0.95) cm/year to 8.4 (SD = 1.1) cm/year after 1 year of GH treatment without accelerated advancement of skeletal maturation. The serum IGF-1 levels also increased significantly with treatment. In nine children-who remained prepubertal followed for one year after GH treatment, the mean growth velocity increased from 4.5 (SD = 0.69) cm/year before treatment to 8.7 (SD = 1.28) cm/year after 1 year of GH treatment (p < 0.0001). After stopping GH treatment, the growth velocity decreased significantly (p < 0.001) to 2.4 (SD = 0.68) cm/year during the first year of follow-up. In the six prepubertal children followed up for 2 years after treatment, the mean growth velocity was 4.1. (SD = 1.04) cm/ year which was not significantly different from the pretreatment growth velocity. The significant decrease in growth velocity during the first post-treatment year could not be explained by the usual fall of growth velocity with increasing age in prepubertal children. Our results indicate that the effect of one year of GH treatment on height gain is partly transient and cast doubt on the efficacy of short-term GH therapy in short non-GH deficient patients.en_HK
dc.languageengen_HK
dc.publisherFreund Publishing House, Ltd. The Journal's web site is located at http://www.freundpublishing.com/Journal_Pediatric_Endocrinology_Metabolism/JPEMprev.htmen_HK
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_HK
dc.subjectCatch-down growth posttreatmenten_HK
dc.subjectnon-GH deficienten_HK
dc.titleA partial transient effect of short-term growth hormone (GH) treatment in short non-GH deficient prepubertal childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8521191-
dc.identifier.scopuseid_2-s2.0-0029116063en_HK
dc.identifier.hkuros8418en_HK
dc.identifier.volume8en_HK
dc.identifier.issue3en_HK
dc.identifier.spage173en_HK
dc.identifier.epage179en_HK
dc.identifier.isiWOS:A1995RU79100004-
dc.publisher.placeIsraelen_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK
dc.identifier.scopusauthoridKwan, E=55222528300en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats