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Article: Prospects of EGF transgenic mice researches

TitleProspects of EGF transgenic mice researches
Authors
KeywordsEGF receptor
IGF
IGFBP
Overexpression
Transgenic mice
Issue Date2001
PublisherOxford University Press.
Citation
Acta Biochimica Et Biophysica Sinica, 2001, v. 33 n. 5, p. 475-476 How to Cite?
AbstractGenetic engineering in mice has proven to be a powerful tool for studying the specificity, complementarity and redundancy in the signalling cascades by altering the structure or expression of a single gene or a set of genes, from the ligands themselves to the specific receptors to the downstream signalling players. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. Transgenic and gene-targeted mouse lines have been used extensively to study the function of the EGFR and its ligands, insulin-like growth factor (IGF), their receptors and binding proteins. This mini-review highlights some of the major recent findings pertinent to the EGF and IGF-I/IGFBPS transgenic model. This mini-review summarizes the current knowledge about the actions of EGF and IGFBP in vivo based on the presently established transgenic mice. We focus on results obtained from the application of transgenic and knockout models to determine the roles of EGF, IGFs in the regulation of reproduction and growth development.
Persistent Identifierhttp://hdl.handle.net/10722/79753
ISSN
2003 Impact Factor: 0.524
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWCen_HK
dc.contributor.authorDong, Men_HK
dc.contributor.authorMak, KKLen_HK
dc.contributor.authorChan, SYen_HK
dc.date.accessioned2010-09-06T07:58:17Z-
dc.date.available2010-09-06T07:58:17Z-
dc.date.issued2001en_HK
dc.identifier.citationActa Biochimica Et Biophysica Sinica, 2001, v. 33 n. 5, p. 475-476en_HK
dc.identifier.issn0582-9879en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79753-
dc.description.abstractGenetic engineering in mice has proven to be a powerful tool for studying the specificity, complementarity and redundancy in the signalling cascades by altering the structure or expression of a single gene or a set of genes, from the ligands themselves to the specific receptors to the downstream signalling players. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. Transgenic and gene-targeted mouse lines have been used extensively to study the function of the EGFR and its ligands, insulin-like growth factor (IGF), their receptors and binding proteins. This mini-review highlights some of the major recent findings pertinent to the EGF and IGF-I/IGFBPS transgenic model. This mini-review summarizes the current knowledge about the actions of EGF and IGFBP in vivo based on the presently established transgenic mice. We focus on results obtained from the application of transgenic and knockout models to determine the roles of EGF, IGFs in the regulation of reproduction and growth development.en_HK
dc.languageengen_HK
dc.publisherOxford University Press.en_HK
dc.relation.ispartofActa Biochimica et Biophysica Sinicaen_HK
dc.rightsActa Biochimica et Biophysica Sinica. Copyright © Oxford University Press.en_HK
dc.subjectEGF receptoren_HK
dc.subjectIGFen_HK
dc.subjectIGFBPen_HK
dc.subjectOverexpressionen_HK
dc.subjectTransgenic miceen_HK
dc.titleProspects of EGF transgenic mice researchesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-9145&volume=33&issue=5&spage=473&epage=476&date=2001&atitle=Prospects+of+EGF+Transgenic+Mice+Researchesen_HK
dc.identifier.emailChan, SY:sychan@hkucc.hku.hken_HK
dc.identifier.authorityChan, SY=rp00356en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-20444372712en_HK
dc.identifier.hkuros66047en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444372712&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue5en_HK
dc.identifier.spage475en_HK
dc.identifier.epage476en_HK
dc.identifier.scopusauthoridWong, RWC=13007985800en_HK
dc.identifier.scopusauthoridDong, M=36888068700en_HK
dc.identifier.scopusauthoridMak, KKL=7102679897en_HK
dc.identifier.scopusauthoridChan, SY=7404255082en_HK

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