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Article: A practical chelation protocol based on stratification of thalassemic patients by serum ferritin and magnetic resonance imaging cardiac t2 *

TitleA practical chelation protocol based on stratification of thalassemic patients by serum ferritin and magnetic resonance imaging cardiac t2 *
Authors
KeywordsCardiac T2*
Chelation protocol
Combined therapy
Deferiprone (L1)
Deferoxamine (DFO)
Serum ferritin (SF)
Thalassemia
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
Citation
Hemoglobin, 2009, v. 33 n. 5, p. 323-331 How to Cite?
AbstractOur previous study showed that combined therapy with deferiprone (L1) and deferoxamine (DFO) was safe and efficacious in reducing iron overload in poorly-chelated thalassemia major patients for the short-term but the magnetic resonance imaging (MRI) T2* evaluation was not available at that time. Since October 2006, we applied a standardized chelation protocol by stratifying transfusion-dependent thalassemic patients into three groups, namely well-chelated group (A), poorly-chelated group without (B) or with (C) risk of cardiac complications, based on their serum ferritin (SF) levels and magnetic resonance imaging (MRI) cardiac T2* measurements. The patients in each group were given options of chelation regimens to improve their iron overload status. Chelation regimens included continuation or intensification of DFO alone (Regimen Ic or Ii, respectively), L1 alone (Regimen II), and combined therapy with L1 and DFO (Regimen III). Group A patients continued with Regimen Ic. Group B patients could opt for either Regimen Ii or IIIII. Group C patients could opt for either Regimen Ii or III. Serum ferritin levels and MRI cardiac and liver T2* measurements were evaluated after 1 year of treatment. Fifty-seven patients (27 males, 30 females; age range 534 years, median: 25 years) were categorized into Group A (n = 3), B (n = 20) and C (n = 34). All Group A patients continued with DFO treatment. In Group B, seven were on Regimen Ii, five on Regimen II and five on Regimen III. In Group C, five were on Regimen Ii, two on Regimen II and 26 on Regimen III. Significant improvement was noted only for Group C patients using Regimen III (combined therapy) in SF levels, cardiac T2* and liver T2* measurements. © Informa UK, Ltd.
DescriptionProceedings of the 17th International Conference on Chelation (ICOC), Shenzhen, PR China 23-27 November 2007.
Persistent Identifierhttp://hdl.handle.net/10722/79747
ISSN
2015 Impact Factor: 0.747
2015 SCImago Journal Rankings: 0.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHa, SYen_HK
dc.contributor.authorMok, ASPen_HK
dc.contributor.authorChu, WCWen_HK
dc.contributor.authorRaskalkar, DDen_HK
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-06T07:58:13Z-
dc.date.available2010-09-06T07:58:13Z-
dc.date.issued2009en_HK
dc.identifier.citationHemoglobin, 2009, v. 33 n. 5, p. 323-331en_HK
dc.identifier.issn0363-0269en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79747-
dc.descriptionProceedings of the 17th International Conference on Chelation (ICOC), Shenzhen, PR China 23-27 November 2007.-
dc.description.abstractOur previous study showed that combined therapy with deferiprone (L1) and deferoxamine (DFO) was safe and efficacious in reducing iron overload in poorly-chelated thalassemia major patients for the short-term but the magnetic resonance imaging (MRI) T2* evaluation was not available at that time. Since October 2006, we applied a standardized chelation protocol by stratifying transfusion-dependent thalassemic patients into three groups, namely well-chelated group (A), poorly-chelated group without (B) or with (C) risk of cardiac complications, based on their serum ferritin (SF) levels and magnetic resonance imaging (MRI) cardiac T2* measurements. The patients in each group were given options of chelation regimens to improve their iron overload status. Chelation regimens included continuation or intensification of DFO alone (Regimen Ic or Ii, respectively), L1 alone (Regimen II), and combined therapy with L1 and DFO (Regimen III). Group A patients continued with Regimen Ic. Group B patients could opt for either Regimen Ii or IIIII. Group C patients could opt for either Regimen Ii or III. Serum ferritin levels and MRI cardiac and liver T2* measurements were evaluated after 1 year of treatment. Fifty-seven patients (27 males, 30 females; age range 534 years, median: 25 years) were categorized into Group A (n = 3), B (n = 20) and C (n = 34). All Group A patients continued with DFO treatment. In Group B, seven were on Regimen Ii, five on Regimen II and five on Regimen III. In Group C, five were on Regimen Ii, two on Regimen II and 26 on Regimen III. Significant improvement was noted only for Group C patients using Regimen III (combined therapy) in SF levels, cardiac T2* and liver T2* measurements. © Informa UK, Ltd.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.aspen_HK
dc.relation.ispartofHemoglobinen_HK
dc.rightsHemoglobin. Copyright © Informa Healthcare.en_HK
dc.subjectCardiac T2*en_HK
dc.subjectChelation protocolen_HK
dc.subjectCombined therapyen_HK
dc.subjectDeferiprone (L1)en_HK
dc.subjectDeferoxamine (DFO)en_HK
dc.subjectSerum ferritin (SF)en_HK
dc.subjectThalassemiaen_HK
dc.subject.meshChelation Therapy - methods-
dc.subject.meshFerritins - blood-
dc.subject.meshIron Chelating Agents - administration and dosage - therapeutic use-
dc.subject.meshIron Overload - drug therapy-
dc.subject.meshbeta-Thalassemia - diagnosis - drug therapy-
dc.titleA practical chelation protocol based on stratification of thalassemic patients by serum ferritin and magnetic resonance imaging cardiac t2 *en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0363-0269&volume=33&issue=5&spage=323&epage=331&date=2009&atitle=A+practical+chelation+protocol+based+on+stratification+of+thalassemic+patients+by+serum+ferritin+and+Magnetic+Resonance+Imaging+cardiac+T2*.en_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/03630260903211979en_HK
dc.identifier.pmid19814678-
dc.identifier.scopuseid_2-s2.0-70350694434en_HK
dc.identifier.hkuros168344en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350694434&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue5en_HK
dc.identifier.spage323en_HK
dc.identifier.epage331en_HK
dc.identifier.isiWOS:000271556200006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridMok, ASP=24470317700en_HK
dc.identifier.scopusauthoridChu, WCW=7402227871en_HK
dc.identifier.scopusauthoridRaskalkar, DD=36663796400en_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridHo, MHK=36870597500en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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