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Article: End tidal carbon monoxide concentration in childhood haemolytic disorders

TitleEnd tidal carbon monoxide concentration in childhood haemolytic disorders
Authors
KeywordsCarbon monoxide
Children
Haemolysis
Issue Date1998
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPC
Citation
Journal Of Paediatrics And Child Health, 1998, v. 34 n. 5, p. 447-450 How to Cite?
AbstractObjectives: Endogenous carbon monoxide (CO) is produced mainly by heme catabolism. As CO is excreted solely by the lung, a simple technique for measuring the end tidal carbon monoxide (ETCO) level was assessed as a method for screening for haemolytic disease in children. Methods: Two end expiratory breath samples were collected from normal children and from children with haemolytic disease using a one way valve connector between a mouth piece and an anaesthetic bag. The samples were analysed by gas chromatography for CO and carbon for dioxide (CO2). The CO2 value was used to normalise the CO value to an alveolar concentration. Carboxyhaemoglobin (HbCO) also was measured in the patient group for correlation analysis with ETCO. Results: A total of 21 children with β thalassaemia major, 15 children with other haemolytic diseases (hereditary spherocytosis n=8, haemoglobin H disease n=3 and thalassaemia intermedia n=4) and 23 normal children were studied. The mean ETCO concentrations in the three groups were 3.21 p.p.m., 7.41 p.p.m. and 0.69 p.p.m., respectively, which were significantly different from each other (P<0.0001). There was a significant correlation between ETCO and HbCO in the patient groups (r=0.85; P < 0.0001). Conclusions: The end expiratory breath collection device is a simple and feasible sample collection method. The results confirm that ETCO can be used clinically to distinguish children with a variety of haemolytic disorders from normal subjects.
Persistent Identifierhttp://hdl.handle.net/10722/79743
ISSN
2015 Impact Factor: 1.477
2015 SCImago Journal Rankings: 0.692
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorYeung, CYen_HK
dc.date.accessioned2010-09-06T07:58:10Z-
dc.date.available2010-09-06T07:58:10Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Paediatrics And Child Health, 1998, v. 34 n. 5, p. 447-450en_HK
dc.identifier.issn1034-4810en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79743-
dc.description.abstractObjectives: Endogenous carbon monoxide (CO) is produced mainly by heme catabolism. As CO is excreted solely by the lung, a simple technique for measuring the end tidal carbon monoxide (ETCO) level was assessed as a method for screening for haemolytic disease in children. Methods: Two end expiratory breath samples were collected from normal children and from children with haemolytic disease using a one way valve connector between a mouth piece and an anaesthetic bag. The samples were analysed by gas chromatography for CO and carbon for dioxide (CO2). The CO2 value was used to normalise the CO value to an alveolar concentration. Carboxyhaemoglobin (HbCO) also was measured in the patient group for correlation analysis with ETCO. Results: A total of 21 children with β thalassaemia major, 15 children with other haemolytic diseases (hereditary spherocytosis n=8, haemoglobin H disease n=3 and thalassaemia intermedia n=4) and 23 normal children were studied. The mean ETCO concentrations in the three groups were 3.21 p.p.m., 7.41 p.p.m. and 0.69 p.p.m., respectively, which were significantly different from each other (P<0.0001). There was a significant correlation between ETCO and HbCO in the patient groups (r=0.85; P < 0.0001). Conclusions: The end expiratory breath collection device is a simple and feasible sample collection method. The results confirm that ETCO can be used clinically to distinguish children with a variety of haemolytic disorders from normal subjects.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPCen_HK
dc.relation.ispartofJournal of Paediatrics and Child Healthen_HK
dc.subjectCarbon monoxideen_HK
dc.subjectChildrenen_HK
dc.subjectHaemolysisen_HK
dc.titleEnd tidal carbon monoxide concentration in childhood haemolytic disordersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1034-4810&volume=34&spage=447&epage=450&date=1998&atitle=End+tidal+carbon+monoxide+concentration+in+childhood+haemolytic+disordersen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1754.1998.00270.xen_HK
dc.identifier.pmid9767508-
dc.identifier.scopuseid_2-s2.0-0031726130en_HK
dc.identifier.hkuros38784en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031726130&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue5en_HK
dc.identifier.spage447en_HK
dc.identifier.epage450en_HK
dc.identifier.isiWOS:000076518100011-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridYeung, CY=7201354144en_HK

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