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- Publisher Website: 10.1046/j.1440-1754.1998.00270.x
- Scopus: eid_2-s2.0-0031726130
- PMID: 9767508
- WOS: WOS:000076518100011
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Article: End tidal carbon monoxide concentration in childhood haemolytic disorders
Title | End tidal carbon monoxide concentration in childhood haemolytic disorders |
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Authors | |
Keywords | Carbon monoxide Children Haemolysis |
Issue Date | 1998 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPC |
Citation | Journal Of Paediatrics And Child Health, 1998, v. 34 n. 5, p. 447-450 How to Cite? |
Abstract | Objectives: Endogenous carbon monoxide (CO) is produced mainly by heme catabolism. As CO is excreted solely by the lung, a simple technique for measuring the end tidal carbon monoxide (ETCO) level was assessed as a method for screening for haemolytic disease in children. Methods: Two end expiratory breath samples were collected from normal children and from children with haemolytic disease using a one way valve connector between a mouth piece and an anaesthetic bag. The samples were analysed by gas chromatography for CO and carbon for dioxide (CO2). The CO2 value was used to normalise the CO value to an alveolar concentration. Carboxyhaemoglobin (HbCO) also was measured in the patient group for correlation analysis with ETCO. Results: A total of 21 children with β thalassaemia major, 15 children with other haemolytic diseases (hereditary spherocytosis n=8, haemoglobin H disease n=3 and thalassaemia intermedia n=4) and 23 normal children were studied. The mean ETCO concentrations in the three groups were 3.21 p.p.m., 7.41 p.p.m. and 0.69 p.p.m., respectively, which were significantly different from each other (P<0.0001). There was a significant correlation between ETCO and HbCO in the patient groups (r=0.85; P < 0.0001). Conclusions: The end expiratory breath collection device is a simple and feasible sample collection method. The results confirm that ETCO can be used clinically to distinguish children with a variety of haemolytic disorders from normal subjects. |
Persistent Identifier | http://hdl.handle.net/10722/79743 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.499 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, GCF | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.contributor.author | Yeung, CY | en_HK |
dc.date.accessioned | 2010-09-06T07:58:10Z | - |
dc.date.available | 2010-09-06T07:58:10Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Journal Of Paediatrics And Child Health, 1998, v. 34 n. 5, p. 447-450 | en_HK |
dc.identifier.issn | 1034-4810 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/79743 | - |
dc.description.abstract | Objectives: Endogenous carbon monoxide (CO) is produced mainly by heme catabolism. As CO is excreted solely by the lung, a simple technique for measuring the end tidal carbon monoxide (ETCO) level was assessed as a method for screening for haemolytic disease in children. Methods: Two end expiratory breath samples were collected from normal children and from children with haemolytic disease using a one way valve connector between a mouth piece and an anaesthetic bag. The samples were analysed by gas chromatography for CO and carbon for dioxide (CO2). The CO2 value was used to normalise the CO value to an alveolar concentration. Carboxyhaemoglobin (HbCO) also was measured in the patient group for correlation analysis with ETCO. Results: A total of 21 children with β thalassaemia major, 15 children with other haemolytic diseases (hereditary spherocytosis n=8, haemoglobin H disease n=3 and thalassaemia intermedia n=4) and 23 normal children were studied. The mean ETCO concentrations in the three groups were 3.21 p.p.m., 7.41 p.p.m. and 0.69 p.p.m., respectively, which were significantly different from each other (P<0.0001). There was a significant correlation between ETCO and HbCO in the patient groups (r=0.85; P < 0.0001). Conclusions: The end expiratory breath collection device is a simple and feasible sample collection method. The results confirm that ETCO can be used clinically to distinguish children with a variety of haemolytic disorders from normal subjects. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPC | en_HK |
dc.relation.ispartof | Journal of Paediatrics and Child Health | en_HK |
dc.subject | Carbon monoxide | en_HK |
dc.subject | Children | en_HK |
dc.subject | Haemolysis | en_HK |
dc.title | End tidal carbon monoxide concentration in childhood haemolytic disorders | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1034-4810&volume=34&spage=447&epage=450&date=1998&atitle=End+tidal+carbon+monoxide+concentration+in+childhood+haemolytic+disorders | en_HK |
dc.identifier.email | Chan, GCF:gcfchan@hkucc.hku.hk | en_HK |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, GCF=rp00431 | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1046/j.1440-1754.1998.00270.x | en_HK |
dc.identifier.pmid | 9767508 | - |
dc.identifier.scopus | eid_2-s2.0-0031726130 | en_HK |
dc.identifier.hkuros | 38784 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031726130&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 34 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 447 | en_HK |
dc.identifier.epage | 450 | en_HK |
dc.identifier.isi | WOS:000076518100011 | - |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Chan, GCF=16160154400 | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.scopusauthorid | Yeung, CY=7201354144 | en_HK |
dc.identifier.issnl | 1034-4810 | - |