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Article: Distribution of symptomatic congenital heart disease in Hong Kong
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TitleDistribution of symptomatic congenital heart disease in Hong Kong
 
AuthorsJacobs, EGJ1
Leung, MP1
Karlberg, J1
 
KeywordsCongenital heart disease
Down's syndrome
Ethnic differences
Mortality
 
Issue Date2000
 
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246
 
CitationPediatric Cardiology, 2000, v. 21 n. 2, p. 148-157 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s002469910025
 
AbstractRacial group studies have identified differences in the occurrence of congenital heart disease (CHD) among ethnic populations. The aim of this study was to characterize the proportionate frequency and clinical profile of children with symptomatic cardiac abnormalities in Hong Kong. The hospital records of 666, mainly Southern Chinese children with symptomatic CHD, who were 4 years of age or younger and who were admitted to Grantham Hospital, Hong Kong, in 1994 and 1995 were analyzed retrospectively. Left-to-right shunting (45.0%) and pulmonary outflow obstruction (34.4%) were the most frequently diagnosed categories, followed by left ventricular outflow obstruction (8.3%), transposition of the great arteries (4.2%), conditions with intracardiac mixing (3.9%), and other cardiac lesions (4.2%). Compared with Western studies, pulmonary outflow obstruction (p ≤ 0.0001), particularly tetralogy of Fallot and critical pulmonary stenosis, were more frequent in Chinese children. In contrast with previous reports, coarctation of the aorta (5%) does not seem to be uncommon in Chinese patients. Conversely, aortic stenosis and hypoplastic left ventricle may be rare in these children (1% vs 3% and 3-7%). Other cardiac lesions showed no consistent racial difference in the frequency of occurrence. Chinese patients with Down's syndrome had ventricular septal defect (38%) as the predominant lesion followed by atrioventricular septal defect (25%). Western studies usually report a reverse pattern for these two lesions. The mortality rate for the total cohort was 7.5%. However, of those with conditions with intracardiac mixing and left ventricular outflow tract obstruction many did not survive childhood (20% and 21%, respectively).
 
ISSN0172-0643
2013 Impact Factor: 1.550
 
DOIhttp://dx.doi.org/10.1007/s002469910025
 
ISI Accession Number IDWOS:000086244300009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorJacobs, EGJ
 
dc.contributor.authorLeung, MP
 
dc.contributor.authorKarlberg, J
 
dc.date.accessioned2010-09-06T07:58:08Z
 
dc.date.available2010-09-06T07:58:08Z
 
dc.date.issued2000
 
dc.description.abstractRacial group studies have identified differences in the occurrence of congenital heart disease (CHD) among ethnic populations. The aim of this study was to characterize the proportionate frequency and clinical profile of children with symptomatic cardiac abnormalities in Hong Kong. The hospital records of 666, mainly Southern Chinese children with symptomatic CHD, who were 4 years of age or younger and who were admitted to Grantham Hospital, Hong Kong, in 1994 and 1995 were analyzed retrospectively. Left-to-right shunting (45.0%) and pulmonary outflow obstruction (34.4%) were the most frequently diagnosed categories, followed by left ventricular outflow obstruction (8.3%), transposition of the great arteries (4.2%), conditions with intracardiac mixing (3.9%), and other cardiac lesions (4.2%). Compared with Western studies, pulmonary outflow obstruction (p ≤ 0.0001), particularly tetralogy of Fallot and critical pulmonary stenosis, were more frequent in Chinese children. In contrast with previous reports, coarctation of the aorta (5%) does not seem to be uncommon in Chinese patients. Conversely, aortic stenosis and hypoplastic left ventricle may be rare in these children (1% vs 3% and 3-7%). Other cardiac lesions showed no consistent racial difference in the frequency of occurrence. Chinese patients with Down's syndrome had ventricular septal defect (38%) as the predominant lesion followed by atrioventricular septal defect (25%). Western studies usually report a reverse pattern for these two lesions. The mortality rate for the total cohort was 7.5%. However, of those with conditions with intracardiac mixing and left ventricular outflow tract obstruction many did not survive childhood (20% and 21%, respectively).
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationPediatric Cardiology, 2000, v. 21 n. 2, p. 148-157 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s002469910025
 
dc.identifier.doihttp://dx.doi.org/10.1007/s002469910025
 
dc.identifier.epage157
 
dc.identifier.hkuros55323
 
dc.identifier.isiWOS:000086244300009
 
dc.identifier.issn0172-0643
2013 Impact Factor: 1.550
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid10754087
 
dc.identifier.scopuseid_2-s2.0-0034017079
 
dc.identifier.spage148
 
dc.identifier.urihttp://hdl.handle.net/10722/79741
 
dc.identifier.volume21
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPediatric Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.subject.meshAnalysis of Variance
 
dc.subject.meshChi-Square Distribution
 
dc.subject.meshFemale
 
dc.subject.meshHeart Defects, Congenital - epidemiology - ethnology - surgery
 
dc.subject.meshHong Kong - epidemiology
 
dc.subjectCongenital heart disease
 
dc.subjectDown's syndrome
 
dc.subjectEthnic differences
 
dc.subjectMortality
 
dc.titleDistribution of symptomatic congenital heart disease in Hong Kong
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong