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Article: Distribution of symptomatic congenital heart disease in Hong Kong

TitleDistribution of symptomatic congenital heart disease in Hong Kong
Authors
KeywordsCongenital heart disease
Down's syndrome
Ethnic differences
Mortality
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246
Citation
Pediatric Cardiology, 2000, v. 21 n. 2, p. 148-157 How to Cite?
AbstractRacial group studies have identified differences in the occurrence of congenital heart disease (CHD) among ethnic populations. The aim of this study was to characterize the proportionate frequency and clinical profile of children with symptomatic cardiac abnormalities in Hong Kong. The hospital records of 666, mainly Southern Chinese children with symptomatic CHD, who were 4 years of age or younger and who were admitted to Grantham Hospital, Hong Kong, in 1994 and 1995 were analyzed retrospectively. Left-to-right shunting (45.0%) and pulmonary outflow obstruction (34.4%) were the most frequently diagnosed categories, followed by left ventricular outflow obstruction (8.3%), transposition of the great arteries (4.2%), conditions with intracardiac mixing (3.9%), and other cardiac lesions (4.2%). Compared with Western studies, pulmonary outflow obstruction (p ≤ 0.0001), particularly tetralogy of Fallot and critical pulmonary stenosis, were more frequent in Chinese children. In contrast with previous reports, coarctation of the aorta (5%) does not seem to be uncommon in Chinese patients. Conversely, aortic stenosis and hypoplastic left ventricle may be rare in these children (1% vs 3% and 3-7%). Other cardiac lesions showed no consistent racial difference in the frequency of occurrence. Chinese patients with Down's syndrome had ventricular septal defect (38%) as the predominant lesion followed by atrioventricular septal defect (25%). Western studies usually report a reverse pattern for these two lesions. The mortality rate for the total cohort was 7.5%. However, of those with conditions with intracardiac mixing and left ventricular outflow tract obstruction many did not survive childhood (20% and 21%, respectively).
Persistent Identifierhttp://hdl.handle.net/10722/79741
ISSN
2015 Impact Factor: 1.452
2015 SCImago Journal Rankings: 0.732
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJacobs, EGJen_HK
dc.contributor.authorLeung, MPen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.date.accessioned2010-09-06T07:58:08Z-
dc.date.available2010-09-06T07:58:08Z-
dc.date.issued2000en_HK
dc.identifier.citationPediatric Cardiology, 2000, v. 21 n. 2, p. 148-157en_HK
dc.identifier.issn0172-0643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79741-
dc.description.abstractRacial group studies have identified differences in the occurrence of congenital heart disease (CHD) among ethnic populations. The aim of this study was to characterize the proportionate frequency and clinical profile of children with symptomatic cardiac abnormalities in Hong Kong. The hospital records of 666, mainly Southern Chinese children with symptomatic CHD, who were 4 years of age or younger and who were admitted to Grantham Hospital, Hong Kong, in 1994 and 1995 were analyzed retrospectively. Left-to-right shunting (45.0%) and pulmonary outflow obstruction (34.4%) were the most frequently diagnosed categories, followed by left ventricular outflow obstruction (8.3%), transposition of the great arteries (4.2%), conditions with intracardiac mixing (3.9%), and other cardiac lesions (4.2%). Compared with Western studies, pulmonary outflow obstruction (p ≤ 0.0001), particularly tetralogy of Fallot and critical pulmonary stenosis, were more frequent in Chinese children. In contrast with previous reports, coarctation of the aorta (5%) does not seem to be uncommon in Chinese patients. Conversely, aortic stenosis and hypoplastic left ventricle may be rare in these children (1% vs 3% and 3-7%). Other cardiac lesions showed no consistent racial difference in the frequency of occurrence. Chinese patients with Down's syndrome had ventricular septal defect (38%) as the predominant lesion followed by atrioventricular septal defect (25%). Western studies usually report a reverse pattern for these two lesions. The mortality rate for the total cohort was 7.5%. However, of those with conditions with intracardiac mixing and left ventricular outflow tract obstruction many did not survive childhood (20% and 21%, respectively).en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246en_HK
dc.relation.ispartofPediatric Cardiologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectCongenital heart diseaseen_HK
dc.subjectDown's syndromeen_HK
dc.subjectEthnic differencesen_HK
dc.subjectMortalityen_HK
dc.subject.meshAnalysis of Variance-
dc.subject.meshChi-Square Distribution-
dc.subject.meshFemale-
dc.subject.meshHeart Defects, Congenital - epidemiology - ethnology - surgery-
dc.subject.meshHong Kong - epidemiology-
dc.titleDistribution of symptomatic congenital heart disease in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0172-0643&volume=21&issue=2&spage=148&epage=157&date=2000&atitle=Distribution+of+symptomatic+congenital+heart+disease+in+Hong+Kongen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s002469910025en_HK
dc.identifier.pmid10754087-
dc.identifier.scopuseid_2-s2.0-0034017079en_HK
dc.identifier.hkuros55323en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034017079&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue2en_HK
dc.identifier.spage148en_HK
dc.identifier.epage157en_HK
dc.identifier.isiWOS:000086244300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJacobs, EGJ=7201382540en_HK
dc.identifier.scopusauthoridLeung, MP=7201944800en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK

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