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Article: The performance of a bone-derived scaffold material in the repair of critical bone defects in a rhesus monkey model

TitleThe performance of a bone-derived scaffold material in the repair of critical bone defects in a rhesus monkey model
Authors
KeywordsBone marrow mesenchymal stem cells
Bone-derived material
Critical bone defects
Rhesus monkey
Tissue-engineered bone
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2007, v. 28 n. 22, p. 3314-3324 How to Cite?
AbstractThe efficacy and safety of a material derived from human bones in the repair of critical segmental bone defects are evaluated in a rhesus monkey model. Frozen human bones were chemically and physically processed into a partially demineralized and deproteinized material in blocks. The complete tissue-engineered (TE) bone was constructed of the material preseeded with allogeneic bone marrow mesenchymal stem cells (MSCs). The material alone and the TE bone were, respectively, implanted to bridge 2.5 cm-long critical defects in right and left radii of 15 monkeys. At weeks 1, 2, 3, 6 and 12 post-implantation, the grafts were collected from three animals and assessed for the local expression of osteogenic markers, histological and roentgenographic features, and immune reactions. It was shown that defects were well repaired with both treatments whereas the bone defects in 2 additional untreated animals remained the same size after 12 weeks. In radii implanted with the TE bones, the repair processes were approximately 3 weeks faster and new bones were formed in a multipoint way. There was neither observable toxic effect nor overt immune rejection in any animals. Taken together, these observations suggest that the TE bone blocks composited of the allogeneic or xenogeneic bone-derived scaffold and allogeneic MSCs may provide an ideal method for repairing large segmental bone defects. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79726
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXie, Hen_HK
dc.contributor.authorYang, Fen_HK
dc.contributor.authorDeng, Len_HK
dc.contributor.authorLuo, Jen_HK
dc.contributor.authorQin, Ten_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorZhou, GQen_HK
dc.contributor.authorYang, Zen_HK
dc.date.accessioned2010-09-06T07:57:53Z-
dc.date.available2010-09-06T07:57:53Z-
dc.date.issued2007en_HK
dc.identifier.citationBiomaterials, 2007, v. 28 n. 22, p. 3314-3324en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79726-
dc.description.abstractThe efficacy and safety of a material derived from human bones in the repair of critical segmental bone defects are evaluated in a rhesus monkey model. Frozen human bones were chemically and physically processed into a partially demineralized and deproteinized material in blocks. The complete tissue-engineered (TE) bone was constructed of the material preseeded with allogeneic bone marrow mesenchymal stem cells (MSCs). The material alone and the TE bone were, respectively, implanted to bridge 2.5 cm-long critical defects in right and left radii of 15 monkeys. At weeks 1, 2, 3, 6 and 12 post-implantation, the grafts were collected from three animals and assessed for the local expression of osteogenic markers, histological and roentgenographic features, and immune reactions. It was shown that defects were well repaired with both treatments whereas the bone defects in 2 additional untreated animals remained the same size after 12 weeks. In radii implanted with the TE bones, the repair processes were approximately 3 weeks faster and new bones were formed in a multipoint way. There was neither observable toxic effect nor overt immune rejection in any animals. Taken together, these observations suggest that the TE bone blocks composited of the allogeneic or xenogeneic bone-derived scaffold and allogeneic MSCs may provide an ideal method for repairing large segmental bone defects. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsBiomaterials. Copyright © Elsevier BV.en_HK
dc.subjectBone marrow mesenchymal stem cellsen_HK
dc.subjectBone-derived materialen_HK
dc.subjectCritical bone defectsen_HK
dc.subjectRhesus monkeyen_HK
dc.subjectTissue-engineered boneen_HK
dc.titleThe performance of a bone-derived scaffold material in the repair of critical bone defects in a rhesus monkey modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-9612&volume=28 &issue=22&spage=3314&epage=3324&date=2007&atitle=The+Performance+of+a+Bone-derived+Scaffold+Material+in+The+Repair+of+Critical+Bone+Defects+in+a+Rhesus+Monkey+Modelen_HK
dc.identifier.emailZhou, GQ:wormoscz@gmail.comen_HK
dc.identifier.authorityZhou, GQ=rp00527en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2007.04.001en_HK
dc.identifier.pmid17462728-
dc.identifier.scopuseid_2-s2.0-34247872999en_HK
dc.identifier.hkuros134342en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247872999&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue22en_HK
dc.identifier.spage3314en_HK
dc.identifier.epage3324en_HK
dc.identifier.isiWOS:000247045600006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridXie, H=7401672194en_HK
dc.identifier.scopusauthoridYang, F=7403449358en_HK
dc.identifier.scopusauthoridDeng, L=37001461300en_HK
dc.identifier.scopusauthoridLuo, J=8262608900en_HK
dc.identifier.scopusauthoridQin, T=7006292617en_HK
dc.identifier.scopusauthoridLi, X=8262608800en_HK
dc.identifier.scopusauthoridZhou, GQ=23394245100en_HK
dc.identifier.scopusauthoridYang, Z=7405433260en_HK

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