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Article: Intervertebral disc autografting in a bipedal animal model

TitleIntervertebral disc autografting in a bipedal animal model
Authors
Issue Date1997
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/
Citation
Clinical Orthopaedics And Related Research, 1997 n. 337, p. 13-26 How to Cite?
AbstractFusion of the spine while restoring stability of the spinal segment, fails to preserve spinal mobility. Long term complications of accelerated degeneration in the neighboring segments have been reported. The present study explores the possibility of intervertebral disc autografting in a bipedal animal model by isolating a lumbar disc together with the adjacent end plates and repositioning it with minimal internal fixation. Fourteen Rhesus monkeys were sacrificed at 2, 4, 6, and 12 months after surgery and the grafted discs were examined radiologically, biochemically, pathologically, and biomechanically. Healing of the bony end plate was seen between 2 to 4 months postoperatively. There was early loss of disc height at 2 and 4 months but there was a suggestion of some reconstitution up to 12 months. There was minimal evidence of gross degeneration at all stages. Gradual loss of water content was found in the annulus and the nucleus. The nucleus pulposus seemed to be able to reaccumulate proteoglycan after an initial drop in the first 4 months. There was significant increase in hydroxyproline content in the annulus fibrosus and the nucleus pulposus. Biomechanically, the grafted disc showed hypermobility in the first 4 months but gradually became stabilized with time. Results from this study suggested that a fresh intervertebral disc autograft could survive a period of ischemia. Although the physiology of the disc was deranged, it was able to preserve a certain degree of segmental mobility without sacrificing stability. Further studies are required to validate these results and the field of disc allografting should be explored.
Persistent Identifierhttp://hdl.handle.net/10722/79704
ISSN
2015 Impact Factor: 3.127
2015 SCImago Journal Rankings: 2.094
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorRuan, DKen_HK
dc.contributor.authorChow, DHKen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2010-09-06T07:57:38Z-
dc.date.available2010-09-06T07:57:38Z-
dc.date.issued1997en_HK
dc.identifier.citationClinical Orthopaedics And Related Research, 1997 n. 337, p. 13-26en_HK
dc.identifier.issn0009-921Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79704-
dc.description.abstractFusion of the spine while restoring stability of the spinal segment, fails to preserve spinal mobility. Long term complications of accelerated degeneration in the neighboring segments have been reported. The present study explores the possibility of intervertebral disc autografting in a bipedal animal model by isolating a lumbar disc together with the adjacent end plates and repositioning it with minimal internal fixation. Fourteen Rhesus monkeys were sacrificed at 2, 4, 6, and 12 months after surgery and the grafted discs were examined radiologically, biochemically, pathologically, and biomechanically. Healing of the bony end plate was seen between 2 to 4 months postoperatively. There was early loss of disc height at 2 and 4 months but there was a suggestion of some reconstitution up to 12 months. There was minimal evidence of gross degeneration at all stages. Gradual loss of water content was found in the annulus and the nucleus. The nucleus pulposus seemed to be able to reaccumulate proteoglycan after an initial drop in the first 4 months. There was significant increase in hydroxyproline content in the annulus fibrosus and the nucleus pulposus. Biomechanically, the grafted disc showed hypermobility in the first 4 months but gradually became stabilized with time. Results from this study suggested that a fresh intervertebral disc autograft could survive a period of ischemia. Although the physiology of the disc was deranged, it was able to preserve a certain degree of segmental mobility without sacrificing stability. Further studies are required to validate these results and the field of disc allografting should be explored.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/en_HK
dc.relation.ispartofClinical Orthopaedics and Related Researchen_HK
dc.rightsClinical Orthopaedics and Related Research. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleIntervertebral disc autografting in a bipedal animal modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-921X&volume=337&spage=13&epage=26&date=1997&atitle=Intervertebral+disc+autografting+in+a+bipedal+animal+modelen_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9137172-
dc.identifier.scopuseid_2-s2.0-0030982799en_HK
dc.identifier.hkuros25228en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030982799&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.issue337en_HK
dc.identifier.spage13en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:A1997WT70700003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridRuan, DK=7004456354en_HK
dc.identifier.scopusauthoridChow, DHK=7103203940en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

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