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Article: Nicolau syndrome following intramuscular diclofenac administration: a case report.

TitleNicolau syndrome following intramuscular diclofenac administration: a case report.
Authors
Issue Date2006
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.josonline.org/
Citation
Journal Of Orthopaedic Surgery (Hong Kong), 2006, v. 14 n. 1, p. 104-107 How to Cite?
AbstractNicolau syndrome (livedoid dermatitis) is a rare adverse reaction of a still largely unidentified pathogenesis at the site of intramuscular drug injection. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, haemorrhagic patch, and finally necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has been related to the administration of a variety of drugs, including non-steroidal anti-inflammatory drugs, corticosteroids, and penicillin. We report a case of Nicolau syndrome following an intramuscular injection of diclofenac. The large ulceration over the right buttock was positive for Pseudomonas aeruginosa, and histology revealed subcutaneous fat necrosis and non-specific inflammation with no evidence of malignancy or vasculitis. The lesion required multiple debridements and a partial-thickness skin graft. Subcutaneous injection, rather than intramuscular injection, was found to be a determining factor in this case. Clinicians must be cautious in the use of proper injection procedures, including appropriate needle length, in order to minimise complications.
Persistent Identifierhttp://hdl.handle.net/10722/79628
ISSN
2015 Impact Factor: 0.542
2015 SCImago Journal Rankings: 0.458

 

DC FieldValueLanguage
dc.contributor.authorLie, Cen_HK
dc.contributor.authorLeung, Fen_HK
dc.contributor.authorChow, SPen_HK
dc.date.accessioned2010-09-06T07:56:47Z-
dc.date.available2010-09-06T07:56:47Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Orthopaedic Surgery (Hong Kong), 2006, v. 14 n. 1, p. 104-107en_HK
dc.identifier.issn1022-5536en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79628-
dc.description.abstractNicolau syndrome (livedoid dermatitis) is a rare adverse reaction of a still largely unidentified pathogenesis at the site of intramuscular drug injection. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, haemorrhagic patch, and finally necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has been related to the administration of a variety of drugs, including non-steroidal anti-inflammatory drugs, corticosteroids, and penicillin. We report a case of Nicolau syndrome following an intramuscular injection of diclofenac. The large ulceration over the right buttock was positive for Pseudomonas aeruginosa, and histology revealed subcutaneous fat necrosis and non-specific inflammation with no evidence of malignancy or vasculitis. The lesion required multiple debridements and a partial-thickness skin graft. Subcutaneous injection, rather than intramuscular injection, was found to be a determining factor in this case. Clinicians must be cautious in the use of proper injection procedures, including appropriate needle length, in order to minimise complications.en_HK
dc.languageengen_HK
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.josonline.org/en_HK
dc.relation.ispartofJournal of orthopaedic surgery (Hong Kong)en_HK
dc.titleNicolau syndrome following intramuscular diclofenac administration: a case report.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1022-5536&volume=14&issue=1&spage=104&epage=107&date=2006&atitle=Nicolau+syndrome+following+intramuscular+diclofenac+administration:+A+case+reporten_HK
dc.identifier.emailLeung, F: klleunga@hku.hken_HK
dc.identifier.emailChow, SP: spchow@hku.hken_HK
dc.identifier.authorityLeung, F=rp00297en_HK
dc.identifier.authorityChow, SP=rp00064en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16598099-
dc.identifier.scopuseid_2-s2.0-33750209401en_HK
dc.identifier.hkuros120281en_HK
dc.identifier.volume14en_HK
dc.identifier.issue1en_HK
dc.identifier.spage104en_HK
dc.identifier.epage107en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLie, C=23498119400en_HK
dc.identifier.scopusauthoridLeung, F=7103078631en_HK
dc.identifier.scopusauthoridChow, SP=7201828376en_HK

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