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Article: Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement

TitleCharacteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement
Authors
KeywordsAcrylolpamidronate
Bioactive bone cement
Cytotoxicity
Mechanical properties
Surface chemistry
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2007, v. 83 n. 2, p. 464-471 How to Cite?
AbstractThe aim of the present study was to determine the influence of surface treatment on the mechanical properties of strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement. Previously we developed an injectable bioactive cement (SrHAC) system composed of Sr-HA powders and bisphenol A diglycidylether dimethacrylate (Bis-GMA). In this study, the Sr-HA powder was subjected to surface treatment using acrylolpamidronate, a bisphosphonate derivative, which has a polymerizable group, to improve the interface between inorganic filler and organic matrix by binding Sr-HA and copolymerizing into the matrix. After surface treatment, the compression strength, bending strength, and stiffness of the resulting composites were defined by using a material testing machine (MTS) according to ISO 5833. The fracture surface of the bone cement specimen was observed with a scanning electron microscope. In vitro cytotoxicity of surface-treated SrHAC was also studied using a tetrazolium-based cell viability assay (MTS/pms) on human osteoblast-like cells, the SaOS-2 cell line. Cells were seeded at a density of 10 4/mL and allowed to grow in an incubator for 48 h at 37°C. Results indicated that after surface treatment, the compression strength and stiffness significantly improved by 22.68 and 14.51%, respectively. The bending strength and stiffness of the bioactive bone cement also showed 19.06 and 8.91% improvements via three-point bending test. The fracture surface micromorphology after compression and bending revealed that the bonding between the resin to surface-treated filler considerably improved. The cell viability indicated that the treated particles were nontoxic and did not inhibit cell growth. This study demonstrated a new surface chemistry route to enhance the covalent bonds between inorganic fillers and polymer matrix for improving the mechanical properties of bone cement. This method not only improves the overall mechanical performance but also increases osteoblastic activity. © 2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/79557
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorYang, Cen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorXu, Ben_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorNi, GXen_HK
dc.contributor.authorAbbah, SAen_HK
dc.contributor.authorYang, Fen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-09-06T07:56:00Z-
dc.date.available2010-09-06T07:56:00Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2007, v. 83 n. 2, p. 464-471en_HK
dc.identifier.issn1552-4973en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79557-
dc.description.abstractThe aim of the present study was to determine the influence of surface treatment on the mechanical properties of strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement. Previously we developed an injectable bioactive cement (SrHAC) system composed of Sr-HA powders and bisphenol A diglycidylether dimethacrylate (Bis-GMA). In this study, the Sr-HA powder was subjected to surface treatment using acrylolpamidronate, a bisphosphonate derivative, which has a polymerizable group, to improve the interface between inorganic filler and organic matrix by binding Sr-HA and copolymerizing into the matrix. After surface treatment, the compression strength, bending strength, and stiffness of the resulting composites were defined by using a material testing machine (MTS) according to ISO 5833. The fracture surface of the bone cement specimen was observed with a scanning electron microscope. In vitro cytotoxicity of surface-treated SrHAC was also studied using a tetrazolium-based cell viability assay (MTS/pms) on human osteoblast-like cells, the SaOS-2 cell line. Cells were seeded at a density of 10 4/mL and allowed to grow in an incubator for 48 h at 37°C. Results indicated that after surface treatment, the compression strength and stiffness significantly improved by 22.68 and 14.51%, respectively. The bending strength and stiffness of the bioactive bone cement also showed 19.06 and 8.91% improvements via three-point bending test. The fracture surface micromorphology after compression and bending revealed that the bonding between the resin to surface-treated filler considerably improved. The cell viability indicated that the treated particles were nontoxic and did not inhibit cell growth. This study demonstrated a new surface chemistry route to enhance the covalent bonds between inorganic fillers and polymer matrix for improving the mechanical properties of bone cement. This method not only improves the overall mechanical performance but also increases osteoblastic activity. © 2007 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_HK
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAcrylolpamidronateen_HK
dc.subjectBioactive bone cementen_HK
dc.subjectCytotoxicityen_HK
dc.subjectMechanical propertiesen_HK
dc.subjectSurface chemistryen_HK
dc.subject.meshAcrylates - chemistry-
dc.subject.meshBone Cements - chemistry - toxicity-
dc.subject.meshCompressive Strength-
dc.subject.meshDiphosphonates - chemistry-
dc.subject.meshDurapatite - chemistry-
dc.titleCharacteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cementen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.30818en_HK
dc.identifier.pmid17415774-
dc.identifier.scopuseid_2-s2.0-35548959646en_HK
dc.identifier.hkuros144030en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35548959646&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue2en_HK
dc.identifier.spage464en_HK
dc.identifier.epage471en_HK
dc.identifier.isiWOS:000250425400023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridYang, C=55223257900en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridXu, B=24752310700en_HK
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridNi, GX=8303037400en_HK
dc.identifier.scopusauthoridAbbah, SA=14032930600en_HK
dc.identifier.scopusauthoridYang, F=7403449846en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK

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