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Article: Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy

TitleEffect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy
Authors
KeywordsChicken
Light suppression
Melatonin
Pinealectomy
Scoliosis
Issue Date2003
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2003, v. 28 n. 17, p. 1941-1944 How to Cite?
AbstractStudy Design. This study was designed to compare the effect of suppression of melatonin secretion by bright light in chickens with that of surgical pinealectomy. Objective. To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development. Summary of Background Data. Pinealectomy in chickens consistently produces scoliosis with anatomic characteristics similar to those of human idiopathic scoliosis. Conversely, cutting of the pineal stalk without removal of the pineal gland will also result in scoliosis. This study addresses the question of whether constant bright light can induce scoliosis formation, because it is well known that 24-hour bright lighting conditions can suppress the secretion of melatonin to an equivalent level as pinealectomy. Materials and Method. Seventy-seven newborn Nihon chickens were separated into three groups. A control group (n = 21) with no surgery performed; a pinealectomy group (n = 15) that served as surgical controls; and a constant light group (n = 41). The first two groups were kept together in a strict 12-hour light-dark cycle, whereas the third group was separately kept with constant lighting conditions (>100 lux). All the chickens were radiographed at two weekly intervals, and blood was taken during the middle of the light and dark cycles for serum melatonin assay using ELISA. Results. Fifty-four percent of the pinealectomized chickens had scoliosis develop by 6 weeks. None of the constant-light chickens or controls had scoliosis develop for up to 11 weeks. Measurements of serum melatonin levels of the constant light group confirm that secretion is suppressed. Conclusion. This study suggests that for scoliosis to develop in chickens, the surgical operation itself is important and challenges the role of melatonin as an isolated etiological factor in the development of scoliosis.
Persistent Identifierhttp://hdl.handle.net/10722/79542
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLu, DSen_HK
dc.contributor.authorPoon, AMSen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2010-09-06T07:55:50Z-
dc.date.available2010-09-06T07:55:50Z-
dc.date.issued2003en_HK
dc.identifier.citationSpine, 2003, v. 28 n. 17, p. 1941-1944en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79542-
dc.description.abstractStudy Design. This study was designed to compare the effect of suppression of melatonin secretion by bright light in chickens with that of surgical pinealectomy. Objective. To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development. Summary of Background Data. Pinealectomy in chickens consistently produces scoliosis with anatomic characteristics similar to those of human idiopathic scoliosis. Conversely, cutting of the pineal stalk without removal of the pineal gland will also result in scoliosis. This study addresses the question of whether constant bright light can induce scoliosis formation, because it is well known that 24-hour bright lighting conditions can suppress the secretion of melatonin to an equivalent level as pinealectomy. Materials and Method. Seventy-seven newborn Nihon chickens were separated into three groups. A control group (n = 21) with no surgery performed; a pinealectomy group (n = 15) that served as surgical controls; and a constant light group (n = 41). The first two groups were kept together in a strict 12-hour light-dark cycle, whereas the third group was separately kept with constant lighting conditions (>100 lux). All the chickens were radiographed at two weekly intervals, and blood was taken during the middle of the light and dark cycles for serum melatonin assay using ELISA. Results. Fifty-four percent of the pinealectomized chickens had scoliosis develop by 6 weeks. None of the constant-light chickens or controls had scoliosis develop for up to 11 weeks. Measurements of serum melatonin levels of the constant light group confirm that secretion is suppressed. Conclusion. This study suggests that for scoliosis to develop in chickens, the surgical operation itself is important and challenges the role of melatonin as an isolated etiological factor in the development of scoliosis.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.subjectChickenen_HK
dc.subjectLight suppressionen_HK
dc.subjectMelatoninen_HK
dc.subjectPinealectomyen_HK
dc.subjectScoliosisen_HK
dc.titleEffect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-9869&volume=28&issue=17&spage=1941&epage=1944&date=2003&atitle=Effect+of+melatonin+suppression+on+scoliosis+development+in+chickens+by+either+constant+light+or+surgical+pinealectomyen_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailPoon, AMS: amspoon@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityPoon, AMS=rp00354en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.BRS.0000083140.80750.93en_HK
dc.identifier.pmid12973138-
dc.identifier.scopuseid_2-s2.0-0041834454en_HK
dc.identifier.hkuros87058en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041834454&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue17en_HK
dc.identifier.spage1941en_HK
dc.identifier.epage1944en_HK
dc.identifier.isiWOS:000185248600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLu, DS=7403079533en_HK
dc.identifier.scopusauthoridPoon, AMS=7103068868en_HK
dc.identifier.scopusauthoridWang, T=7405564819en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

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