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Article: Young Investigator Award Winner: Spinal Flexibility Increase after Chymopapain Injection Is Dose Dependent: A Possible Alternative to Anterior Release in Scoliosis

TitleYoung Investigator Award Winner: Spinal Flexibility Increase after Chymopapain Injection Is Dose Dependent: A Possible Alternative to Anterior Release in Scoliosis
Authors
KeywordsAdolescent idiopathic scoliosis
Anterior release
Chemonucleolysis
Chymopapain
Spinal flexibility
Issue Date2004
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2004, v. 29 n. 2, p. 123-128 How to Cite?
AbstractStudy Design. Experimental animal study. Objectives. To investigate whether the increase in spinal flexibility after chymopapain injection is dose dependent and determine the "optimal" dosage of chymopapain to increase spinal flexibility in a rabbit model. Summary of Background Data. Spinal instability after chymopapain injection may result in severe back pain. However, this undesired mechanical effect in treating disc herniation may provide a safe minimally invasive approach for anterior spinal release in scoliosis correction. Methods. A total of 138 lumbar intervertebral discs from 46 New Zealand white rabbits were randomly injected with chymopapain at 6.25, 12.5, 25, 50, 75, and 100 picokatals (pKats)/0.05 mL/disc. The rabbits were killed 1 week after the injection, and the lateral bending stiffness of the spinal segments without posterior elements was determined. Results. The lateral bending spinal stiffness showed no significant change after injection of 6.25 and 12.5 pKats/0.05 mL/disc but reduced significantly following chymopapain injection of 25, 50, 75, and 100 pKats (all P < 0.05 by post hoc least significant difference tests). While the lateral bending stiffness was lowest at the 100-pKats dose, there were no significant differences between the four higher dosages. Conclusion. The reduction in the lateral bending spinal stiffness after chymopapain injection is dose dependent, and an optimal dosage for spinal release existed; doses greater than the optimal dosage did not result in further significant decrease in lateral bending spinal stiffness.
Persistent Identifierhttp://hdl.handle.net/10722/79491
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, DSen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2010-09-06T07:55:16Z-
dc.date.available2010-09-06T07:55:16Z-
dc.date.issued2004en_HK
dc.identifier.citationSpine, 2004, v. 29 n. 2, p. 123-128en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79491-
dc.description.abstractStudy Design. Experimental animal study. Objectives. To investigate whether the increase in spinal flexibility after chymopapain injection is dose dependent and determine the "optimal" dosage of chymopapain to increase spinal flexibility in a rabbit model. Summary of Background Data. Spinal instability after chymopapain injection may result in severe back pain. However, this undesired mechanical effect in treating disc herniation may provide a safe minimally invasive approach for anterior spinal release in scoliosis correction. Methods. A total of 138 lumbar intervertebral discs from 46 New Zealand white rabbits were randomly injected with chymopapain at 6.25, 12.5, 25, 50, 75, and 100 picokatals (pKats)/0.05 mL/disc. The rabbits were killed 1 week after the injection, and the lateral bending stiffness of the spinal segments without posterior elements was determined. Results. The lateral bending spinal stiffness showed no significant change after injection of 6.25 and 12.5 pKats/0.05 mL/disc but reduced significantly following chymopapain injection of 25, 50, 75, and 100 pKats (all P < 0.05 by post hoc least significant difference tests). While the lateral bending stiffness was lowest at the 100-pKats dose, there were no significant differences between the four higher dosages. Conclusion. The reduction in the lateral bending spinal stiffness after chymopapain injection is dose dependent, and an optimal dosage for spinal release existed; doses greater than the optimal dosage did not result in further significant decrease in lateral bending spinal stiffness.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.subjectAdolescent idiopathic scoliosisen_HK
dc.subjectAnterior releaseen_HK
dc.subjectChemonucleolysisen_HK
dc.subjectChymopapainen_HK
dc.subjectSpinal flexibilityen_HK
dc.titleYoung Investigator Award Winner: Spinal Flexibility Increase after Chymopapain Injection Is Dose Dependent: A Possible Alternative to Anterior Release in Scoliosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-9869&volume=29&issue=2&spage=123&epage=128&date=2004&atitle=Spinal+flexibility+increase+after+chymopapain+injection+is+dose-dependent:+a+possible+alternative+to+anterior+release+in+scoliosisen_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.BRS.0000107003.19164.18en_HK
dc.identifier.pmid14722402-
dc.identifier.scopuseid_2-s2.0-1642579723en_HK
dc.identifier.hkuros87073en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642579723&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage123en_HK
dc.identifier.epage128en_HK
dc.identifier.isiWOS:000220040000003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, DS=7403079533en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

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