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Article: Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty

TitleStrontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty
Authors
KeywordsBone-bonding strength
Goat
Revision hip arthroplasty
Strontium-containing hydroxyapatite bone cement
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2006, v. 27 n. 24, p. 4348-4355 How to Cite?
AbstractClinical outcome of cemented implants to revision total hip replacement (THR) is not as satisfactory as primary THR, due to the loss of bone stock and normal trabecular pattern. This study evaluated a bioactive bone cement, strontium-containing hydroxyapatite (Sr-HA) bone cement, in a goat revision hip hemi-arthroplasty model, and compared outcomes with polymethylmethacrylate (PMMA) bone cement. Nine months after operation, significantly higher bonding strength was found in the Sr-HA group (3.36±1.84 MPa) than in the PMMA bone cement group (1.23±0.73 MPa). After detached from the femoral component, the surface of PMMA bone cement mantle was shown relatively smooth, whereas the surface of the Sr-HA bioactive bone cement mantle was uneven, by SEM observation. EDX analysis detected little calcium and no phosphorus on the surface of PMMA bone cement mantle, while high content of calcium (14.03%) and phosphorus (10.37%) was found on the surface of the Sr-HA bone cement mantle. Even higher content of calcium (17.37%) and phosphorus (10.84%) were detected in the concave area. Intimate contact between Sr-HA bioactive bone cement and bone was demonstrated by histological and SEM observation. New bone bonded to the surface of Sr-HA cement and grew along its surface. However, fibrous tissue was observed between PMMA bone cement and bone. The results showed good bioactivity of Sr-HA bioactive bone cement in this revision hip replacement model using goats. This in vivo study also suggested that Sr-HA bioactive bone cement was superior to PMMA bone cement in terms of bone-bonding strength. Use of bioactive bone cement may be a possible solution overcoming problems associated with the use of PMMA bone cement in revision hip replacement. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79446
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNi, GXen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorZhang, YGen_HK
dc.contributor.authorHao, LBen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorLu, SBen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-09-06T07:54:47Z-
dc.date.available2010-09-06T07:54:47Z-
dc.date.issued2006en_HK
dc.identifier.citationBiomaterials, 2006, v. 27 n. 24, p. 4348-4355en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79446-
dc.description.abstractClinical outcome of cemented implants to revision total hip replacement (THR) is not as satisfactory as primary THR, due to the loss of bone stock and normal trabecular pattern. This study evaluated a bioactive bone cement, strontium-containing hydroxyapatite (Sr-HA) bone cement, in a goat revision hip hemi-arthroplasty model, and compared outcomes with polymethylmethacrylate (PMMA) bone cement. Nine months after operation, significantly higher bonding strength was found in the Sr-HA group (3.36±1.84 MPa) than in the PMMA bone cement group (1.23±0.73 MPa). After detached from the femoral component, the surface of PMMA bone cement mantle was shown relatively smooth, whereas the surface of the Sr-HA bioactive bone cement mantle was uneven, by SEM observation. EDX analysis detected little calcium and no phosphorus on the surface of PMMA bone cement mantle, while high content of calcium (14.03%) and phosphorus (10.37%) was found on the surface of the Sr-HA bone cement mantle. Even higher content of calcium (17.37%) and phosphorus (10.84%) were detected in the concave area. Intimate contact between Sr-HA bioactive bone cement and bone was demonstrated by histological and SEM observation. New bone bonded to the surface of Sr-HA cement and grew along its surface. However, fibrous tissue was observed between PMMA bone cement and bone. The results showed good bioactivity of Sr-HA bioactive bone cement in this revision hip replacement model using goats. This in vivo study also suggested that Sr-HA bioactive bone cement was superior to PMMA bone cement in terms of bone-bonding strength. Use of bioactive bone cement may be a possible solution overcoming problems associated with the use of PMMA bone cement in revision hip replacement. © 2006 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsBiomaterials. Copyright © Elsevier BV.en_HK
dc.subjectBone-bonding strengthen_HK
dc.subjectGoaten_HK
dc.subjectRevision hip arthroplastyen_HK
dc.subjectStrontium-containing hydroxyapatite bone cementen_HK
dc.titleStrontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplastyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-9612&volume=27&spage=4348&epage=4355&date=2006&atitle=Strontium-containing+hydroxyapatite+bioactive+bone+cement+in+revision+hip+arthroplastyen_HK
dc.identifier.emailChiu, KY:pkychiu@hkucc.hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2006.03.048en_HK
dc.identifier.pmid16647752-
dc.identifier.scopuseid_2-s2.0-33646367883en_HK
dc.identifier.hkuros134014en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646367883&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue24en_HK
dc.identifier.spage4348en_HK
dc.identifier.epage4355en_HK
dc.identifier.isiWOS:000238241100009-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNi, GX=8303037400en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridWang, Y=24492555200en_HK
dc.identifier.scopusauthoridZhang, YG=16508280500en_HK
dc.identifier.scopusauthoridHao, LB=8564260200en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridLu, SB=7404228070en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK

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