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Article: Efficacy of a single dose of cefazolin as a prophylactic antibiotic in primary arthroplasty

TitleEfficacy of a single dose of cefazolin as a prophylactic antibiotic in primary arthroplasty
Authors
KeywordsAntibiotic
Antimicrobial prophylaxis
Infection
Prevention
Total joint arthroplasty
Issue Date2003
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/arthroplastyjournal
Citation
Journal Of Arthroplasty, 2003, v. 18 n. 6, p. 714-718 How to Cite?
AbstractWe analyzed the wound infection rate of 1,367 primary total hip and knee arthroplasties performed between 1991 and 1999. Two hundred and fifteen arthroplasties were performed with 3 doses (3 × 750 mg) of cefuroxime, and 1,152 arthroplasties were performed with a single preoperative dose (1 × 1 g) of cefazolin as antimicrobial prophylaxis. All wound infections that occurred within 2 years of the index surgery were analyzed. The deep wound infection rate of total hip arthroplasty was 1.1% (95% confidence interval [CI], 0%-3.3%) in the cefuroxime group and 1.1% (95% CI, 0%-2.2%) in the cefazolin group (Fisher's exact test, P = 1.0). The deep wound infection rate of total knee arthroplasty in the cefuroxime group (1.6%; 95% CI, 0%-3.8%) was not significantly different from the cefazolin group (1.0%; 95% CI, 0.3%-1.7%) (Fisher's exact test, P = .63). We concluded that a single dose (1 g) of cefazolin given at anesthetic induction offered similar protection to 3 doses (3 × 750 mg) of cefuroxime in preventing infection in primary total joint arthroplasty. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79402
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 2.154
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, WMen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorNg, TPen_HK
dc.contributor.authorYau, WPen_HK
dc.contributor.authorChing, PTYen_HK
dc.contributor.authorSeto, WHen_HK
dc.date.accessioned2010-09-06T07:54:17Z-
dc.date.available2010-09-06T07:54:17Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Arthroplasty, 2003, v. 18 n. 6, p. 714-718en_HK
dc.identifier.issn0883-5403en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79402-
dc.description.abstractWe analyzed the wound infection rate of 1,367 primary total hip and knee arthroplasties performed between 1991 and 1999. Two hundred and fifteen arthroplasties were performed with 3 doses (3 × 750 mg) of cefuroxime, and 1,152 arthroplasties were performed with a single preoperative dose (1 × 1 g) of cefazolin as antimicrobial prophylaxis. All wound infections that occurred within 2 years of the index surgery were analyzed. The deep wound infection rate of total hip arthroplasty was 1.1% (95% confidence interval [CI], 0%-3.3%) in the cefuroxime group and 1.1% (95% CI, 0%-2.2%) in the cefazolin group (Fisher's exact test, P = 1.0). The deep wound infection rate of total knee arthroplasty in the cefuroxime group (1.6%; 95% CI, 0%-3.8%) was not significantly different from the cefazolin group (1.0%; 95% CI, 0.3%-1.7%) (Fisher's exact test, P = .63). We concluded that a single dose (1 g) of cefazolin given at anesthetic induction offered similar protection to 3 doses (3 × 750 mg) of cefuroxime in preventing infection in primary total joint arthroplasty. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/arthroplastyjournalen_HK
dc.relation.ispartofJournal of Arthroplastyen_HK
dc.subjectAntibioticen_HK
dc.subjectAntimicrobial prophylaxisen_HK
dc.subjectInfectionen_HK
dc.subjectPreventionen_HK
dc.subjectTotal joint arthroplastyen_HK
dc.titleEfficacy of a single dose of cefazolin as a prophylactic antibiotic in primary arthroplastyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0883-5403&volume=18&issue=6&spage=714&epage=718&date=2003&atitle=Efficacy+of+a+single+dose+of+cefazolin+as+a+prophylactic+antibiotic+in+primary+arthroplastyen_HK
dc.identifier.emailChiu, KY:pkychiu@hkucc.hku.hken_HK
dc.identifier.emailYau, WP:peterwpy@hkucc.hku.hken_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityYau, WP=rp00500en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0883-5403(03)00201-8en_HK
dc.identifier.pmid14513443-
dc.identifier.scopuseid_2-s2.0-0141758370en_HK
dc.identifier.hkuros84888en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141758370&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue6en_HK
dc.identifier.spage714en_HK
dc.identifier.epage718en_HK
dc.identifier.isiWOS:000185572500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, WM=7403430820en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridNg, TP=24438193400en_HK
dc.identifier.scopusauthoridYau, WP=7005822441en_HK
dc.identifier.scopusauthoridChing, PTY=7005847968en_HK
dc.identifier.scopusauthoridSeto, WH=36950521100en_HK

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