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Article: Microfracture and changes in energy absorption to fracture of young vertebral cancellous bone following physiological fatigue loading

TitleMicrofracture and changes in energy absorption to fracture of young vertebral cancellous bone following physiological fatigue loading
Authors
KeywordsEnergy absorption
Fatigue loading
Microfracture
Issue Date2004
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2004, v. 29 n. 11, p. 1196-1201 How to Cite?
Abstract
Study Design. Fifty-five human thoracolumbar vertebrae were randomly fatigue loaded and analyzed. Objectives. The purpose of this study was to explore the relationship between fatigue loading, trabecular microfracture, and energy absorption to fracture in human cadaveric thoracolumbar vertebrae. Background. Although trabecular microfractures are found in vivo and have been produced by fatigue loading in vitro, the effect of the level of physiologic fatigue loading on microfracture and energy absorption has not been investigated. Methods. Fifty-five human thoracolumbar vertebrae (T11-L4) were randomly divided into 5 groups: 1) control (no loading, n = 6); 2) axial compression to yield (n = 7); and 3-5) 20,000 cycles of fatigue loading at 2 Hz (each n = 14). The level of fatigue loading was determined as a proportion of the yield load of Group 2 as follows: 10% (Group 3), 20% (Group 4), and 30% (Group 5). Half of the specimens in groups 3 to 5 were used for radiographic and histomorphometric analysis to determine microfracture density and distribution, whereas the other half were tested to determine the energy absorption to yield failure. Results. No radiographic evidence of gross fracture was found in any of the groups following fatigue loading. A mean 7.5% increase in stiffness was found in specimens subject to cyclic loading at 10% of yield stress (Group 3). Fatigue at 20% (Group 4) and 30% of yield stress (Group 5) caused significantly higher (P < 0.05) increases in mean stiffness of 23.6% and 24.2%, respectively. Microfracture density increased from 0.46/mm2 in Group 3 to 0.66/mm2 in Group 4 and 0.94/mm2 in Group 5 (P < 0.05). The energy absorbed to failure decreased from 21.9 J in Group 3 to 18.1 J and 19.6 J in Groups 4 and 5, respectively (P < 0.05). Conclusions. Fatigue loading at physiologic levels produced microfractures that are not detectable by radiography. Increased fatigue load results in an increase in microfracture density and decrease energy absorbed to fracture, indicating a reduced resistance to further fatigue loading.
Persistent Identifierhttp://hdl.handle.net/10722/79391
ISSN
2013 Impact Factor: 2.447
ISI Accession Number ID
References

 

Author Affiliations
  1. Southern Medical University
  2. The University of Hong Kong
  3. Peking Union Medical College
DC FieldValueLanguage
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheung, KCMen_HK
dc.contributor.authorGuiXing, Qen_HK
dc.contributor.authorShen, JXen_HK
dc.contributor.authorYuen, Len_HK
dc.contributor.authorOuyang, Jen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2010-09-06T07:54:10Z-
dc.date.available2010-09-06T07:54:10Z-
dc.date.issued2004en_HK
dc.identifier.citationSpine, 2004, v. 29 n. 11, p. 1196-1201en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79391-
dc.description.abstractStudy Design. Fifty-five human thoracolumbar vertebrae were randomly fatigue loaded and analyzed. Objectives. The purpose of this study was to explore the relationship between fatigue loading, trabecular microfracture, and energy absorption to fracture in human cadaveric thoracolumbar vertebrae. Background. Although trabecular microfractures are found in vivo and have been produced by fatigue loading in vitro, the effect of the level of physiologic fatigue loading on microfracture and energy absorption has not been investigated. Methods. Fifty-five human thoracolumbar vertebrae (T11-L4) were randomly divided into 5 groups: 1) control (no loading, n = 6); 2) axial compression to yield (n = 7); and 3-5) 20,000 cycles of fatigue loading at 2 Hz (each n = 14). The level of fatigue loading was determined as a proportion of the yield load of Group 2 as follows: 10% (Group 3), 20% (Group 4), and 30% (Group 5). Half of the specimens in groups 3 to 5 were used for radiographic and histomorphometric analysis to determine microfracture density and distribution, whereas the other half were tested to determine the energy absorption to yield failure. Results. No radiographic evidence of gross fracture was found in any of the groups following fatigue loading. A mean 7.5% increase in stiffness was found in specimens subject to cyclic loading at 10% of yield stress (Group 3). Fatigue at 20% (Group 4) and 30% of yield stress (Group 5) caused significantly higher (P < 0.05) increases in mean stiffness of 23.6% and 24.2%, respectively. Microfracture density increased from 0.46/mm2 in Group 3 to 0.66/mm2 in Group 4 and 0.94/mm2 in Group 5 (P < 0.05). The energy absorbed to failure decreased from 21.9 J in Group 3 to 18.1 J and 19.6 J in Groups 4 and 5, respectively (P < 0.05). Conclusions. Fatigue loading at physiologic levels produced microfractures that are not detectable by radiography. Increased fatigue load results in an increase in microfracture density and decrease energy absorbed to fracture, indicating a reduced resistance to further fatigue loading.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.subjectEnergy absorptionen_HK
dc.subjectFatigue loadingen_HK
dc.subjectMicrofractureen_HK
dc.titleMicrofracture and changes in energy absorption to fracture of young vertebral cancellous bone following physiological fatigue loadingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-9869&volume=29&issue=11&spage=1196&epage=1201&date=2004&atitle=Microfracture+and+changes+in+energy+absorption+to+fracture+of+young+vertebral+cancellous+bone+following+physiological+fatigue+loadingen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00007632-200406010-00007en_HK
dc.identifier.pmid15167657en_HK
dc.identifier.scopuseid_2-s2.0-2542469596en_HK
dc.identifier.hkuros94019en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542469596&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1196en_HK
dc.identifier.epage1201en_HK
dc.identifier.isiWOS:000221812800006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridCheung, KCM=7402406744en_HK
dc.identifier.scopusauthoridGuiXing, Q=6504378003en_HK
dc.identifier.scopusauthoridShen, JX=7404929807en_HK
dc.identifier.scopusauthoridYuen, L=7003657418en_HK
dc.identifier.scopusauthoridOuyang, J=10340066300en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

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