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Article: Fresh frozen intervertebral disc allografting in a bipedal animal model

TitleFresh frozen intervertebral disc allografting in a bipedal animal model
Authors
KeywordsAllograft
Animal model
Degeneration
Intervertebral disc
Transplantation
Issue Date2003
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2003, v. 28 n. 9, p. 864-869 How to Cite?
AbstractStudy Design. An in vivo experimental study to examine the possibility of using fresh frozen intervertebral disc allograft in disc transplantation. Objectives. To investigate the long-term radiographic, pathologic, biochemical, and biomechanical changes of fresh frozen disc allograft in a bipedal animal model. Summary of Background Data. It has been shown that intervertebral disc autograft is able to survive and maintain some degree of tissue metabolism and segmental mobility after transplantation in a bipedal animal model. However, the long-term results of disc allografting and the associated problems of graft rejection are unknown. Methods. Seventeen rhesus monkeys (15 male, 2 female) between 5 and 8 years of age and weighing between 6.7 and 11.8 kg were used in this study. Of these 17 subjects, two were used as intervertebral disc donors and three were used as controls for the biomechanical testing. The remaining 12 monkeys were randomly divided into a short-term group (n = 4, followed up for 2, 4, 6, and 8 weeks, respectively), a midterm group (n = 6, 6 months), and a long-term group (n = 2, 24 months). Radiologic, histologic, biochemical, and biomechanical changes were investigated. Results. Radiography and macro- and microhistologic examination showed severe disc degeneration at 24 months of follow-up. Disc height decreased mainly in the early postoperative stage. Decreased water, proteoglycan, and hydroxyprotine contents of the allograft were observed at 6 and 24 months of follow-up. The biomechanical properties of the transplanted allograft were similar to those of control. Conclusion. Fresh frozen disc allografts can survive and maintain some degree of cell metabolism and segmental mobility at 24 months after transplantation. However, severe disc degeneration is also observed at this stage.
Persistent Identifierhttp://hdl.handle.net/10722/79361
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorRuan, DKen_HK
dc.contributor.authorLu, DSen_HK
dc.contributor.authorFei, ZQen_HK
dc.date.accessioned2010-09-06T07:53:49Z-
dc.date.available2010-09-06T07:53:49Z-
dc.date.issued2003en_HK
dc.identifier.citationSpine, 2003, v. 28 n. 9, p. 864-869en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79361-
dc.description.abstractStudy Design. An in vivo experimental study to examine the possibility of using fresh frozen intervertebral disc allograft in disc transplantation. Objectives. To investigate the long-term radiographic, pathologic, biochemical, and biomechanical changes of fresh frozen disc allograft in a bipedal animal model. Summary of Background Data. It has been shown that intervertebral disc autograft is able to survive and maintain some degree of tissue metabolism and segmental mobility after transplantation in a bipedal animal model. However, the long-term results of disc allografting and the associated problems of graft rejection are unknown. Methods. Seventeen rhesus monkeys (15 male, 2 female) between 5 and 8 years of age and weighing between 6.7 and 11.8 kg were used in this study. Of these 17 subjects, two were used as intervertebral disc donors and three were used as controls for the biomechanical testing. The remaining 12 monkeys were randomly divided into a short-term group (n = 4, followed up for 2, 4, 6, and 8 weeks, respectively), a midterm group (n = 6, 6 months), and a long-term group (n = 2, 24 months). Radiologic, histologic, biochemical, and biomechanical changes were investigated. Results. Radiography and macro- and microhistologic examination showed severe disc degeneration at 24 months of follow-up. Disc height decreased mainly in the early postoperative stage. Decreased water, proteoglycan, and hydroxyprotine contents of the allograft were observed at 6 and 24 months of follow-up. The biomechanical properties of the transplanted allograft were similar to those of control. Conclusion. Fresh frozen disc allografts can survive and maintain some degree of cell metabolism and segmental mobility at 24 months after transplantation. However, severe disc degeneration is also observed at this stage.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.subjectAllograften_HK
dc.subjectAnimal modelen_HK
dc.subjectDegenerationen_HK
dc.subjectIntervertebral discen_HK
dc.subjectTransplantationen_HK
dc.titleFresh frozen intervertebral disc allografting in a bipedal animal modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-9869&volume=28&issue=9&spage=864&epage=869&date=2003&atitle=Fresh+frozen+intervertebral+disc+allografting+in+a+bipedal+animal+modelen_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00007632-200305010-00005en_HK
dc.identifier.pmid12941999-
dc.identifier.scopuseid_2-s2.0-0038640593en_HK
dc.identifier.hkuros79410en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038640593&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage864en_HK
dc.identifier.epage869en_HK
dc.identifier.isiWOS:000182585800004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridRuan, DK=7004456354en_HK
dc.identifier.scopusauthoridLu, DS=7403079533en_HK
dc.identifier.scopusauthoridFei, ZQ=36953803900en_HK

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