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Conference Paper: Resorbable metallic implant: finding from an animal model

TitleResorbable metallic implant: finding from an animal model
Authors
KeywordsResorbable
Magnesium
Implant
Degradable
Absorbable
Issue Date2008
PublisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/
Citation
The 2008 International Conference on Multifunctional Materials and Structures, Hong Kong, China, 28-31 July 2008. In Advanced Materials Research, 2008, v. 47-50 pt. 1, p. 604-607 How to Cite?
AbstractResorbable metallic implant of magnesium and its alloys had been studied since the 1900s. However, the excessive gas production resulted in its unpopularity after CoCr alloys and stainless steel were developed. With the advancement of alloying technologies, its use as a resorbable implant has re-emerged recently. Foreign researchers focused on the use of AZ-series and magnesium-rare earth metal alloys. However, the corrosion property of AZ-series alloys is unsatisfactory, and the effect of rare-earth metals on human is poorly studied. Therefore, we have investigated on the feasibility of using commercially available AM-series magnesium alloys. Previous researchers avoided this alloy series presumably because of the potential health effect of manganese, however our toxicological risk assessment revealed that the exposure level would be lower than the NOAEL (No Observable Adverse Effect Level), thus it is unlikely to cause any observable health effect on healthy individuals. Subcutaneous implantation of AM-series magnesium alloys into a mouse model for six months confirmed that, while all alloys tested showed slow corrosion and no observable in vivo toxicity, pitting corrosion did not occur for AM-series alloys but was frequent for AZ91D. This suggests that AM-series magnesium alloys are good candidates of resorbable metallic implants. © 2008 Trans Tech Publications.
DescriptionMain Theme: Multi-functional Materials and Structures
Persistent Identifierhttp://hdl.handle.net/10722/79324
ISBN
ISSN
2015 SCImago Journal Rankings: 0.115
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, CKen_HK
dc.contributor.authorIp, WYen_HK
dc.date.accessioned2010-09-06T07:53:23Z-
dc.date.available2010-09-06T07:53:23Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 2008 International Conference on Multifunctional Materials and Structures, Hong Kong, China, 28-31 July 2008. In Advanced Materials Research, 2008, v. 47-50 pt. 1, p. 604-607en_HK
dc.identifier.isbn978-087849378-4-
dc.identifier.issn1022-6680en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79324-
dc.descriptionMain Theme: Multi-functional Materials and Structures-
dc.description.abstractResorbable metallic implant of magnesium and its alloys had been studied since the 1900s. However, the excessive gas production resulted in its unpopularity after CoCr alloys and stainless steel were developed. With the advancement of alloying technologies, its use as a resorbable implant has re-emerged recently. Foreign researchers focused on the use of AZ-series and magnesium-rare earth metal alloys. However, the corrosion property of AZ-series alloys is unsatisfactory, and the effect of rare-earth metals on human is poorly studied. Therefore, we have investigated on the feasibility of using commercially available AM-series magnesium alloys. Previous researchers avoided this alloy series presumably because of the potential health effect of manganese, however our toxicological risk assessment revealed that the exposure level would be lower than the NOAEL (No Observable Adverse Effect Level), thus it is unlikely to cause any observable health effect on healthy individuals. Subcutaneous implantation of AM-series magnesium alloys into a mouse model for six months confirmed that, while all alloys tested showed slow corrosion and no observable in vivo toxicity, pitting corrosion did not occur for AM-series alloys but was frequent for AZ91D. This suggests that AM-series magnesium alloys are good candidates of resorbable metallic implants. © 2008 Trans Tech Publications.en_HK
dc.languageengen_HK
dc.publisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/en_HK
dc.relation.ispartofAdvanced Materials Researchen_HK
dc.subjectResorbableen_HK
dc.subjectMagnesiumen_HK
dc.subjectImplanten_HK
dc.subjectDegradableen_HK
dc.subjectAbsorbableen_HK
dc.titleResorbable metallic implant: finding from an animal modelen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailIp, WY: wyip@hku.hken_HK
dc.identifier.authorityIp, WY=rp00401en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4028/www.scientific.net/AMR.47-50.604-
dc.identifier.scopuseid_2-s2.0-56349088785en_HK
dc.identifier.hkuros166702en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56349088785&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47-50en_HK
dc.identifier.issuept. 1-
dc.identifier.spage604en_HK
dc.identifier.epage607en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridIp, WY=35549641700en_HK
dc.identifier.scopusauthoridYuen, CK=25823576300en_HK
dc.customcontrol.immutablesml 140807-

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