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Article: Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses

TitleCharacterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses
Authors
Issue Date2007
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2007, v. 81 n. 14, p. 7529-7539 How to Cite?
AbstractHighly pathogenic avian influenza (HPAI) H5N1 viruses are now endemic in many Asian countries, resulting in repeated outbreaks in poultry and increased cases of human infection. The immediate precursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96 (Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong, China, in 1996. From 2000 onwards, many novel reassortant H5N1 influenza viruses or genotypes have emerged in southern China. However, precursors of the Gs/GD-like viruses and their subsequent reassortants have not been fully determined. Here we characterize low-pathogenic avian influenza (LPAI) H5 subtype viruses isolated from poultry and migratory birds in southern China and Europe from the 1970s to the 2000s. Phylogenetic analyses revealed that Gs/GD-like virus was likely derived from an LPAI H5 virus in migratory birds. However, its variants arose from multiple reassortments between Gs/GD-like virus and viruses from migratory birds or with those Eurasian viruses isolated in the 1970s. It is of note that unlike HPAI H5N1 viruses, those recent LPAI H5 viruses have not become established in aquatic or terrestrial poultry. Phylogenetic analyses revealed the dynamic nature of the influenza virus gene pool in Eurasia with repeated transmissions between the eastern and western extremities of the continent. The data also show reassortment between influenza viruses from domestic and migratory birds in this region that has contributed to the expanded diversity of the influenza virus gene pool among poultry in Eurasia. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79292
ISSN
2014 Impact Factor: 4.439
2014 SCImago Journal Rankings: 2.692
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuan, Len_HK
dc.contributor.authorCampitelli, Len_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorLeung, YHCen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorDonatelli, Ien_HK
dc.contributor.authorDelogu, Men_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorFoni, Een_HK
dc.contributor.authorChiapponi, Cen_HK
dc.contributor.authorWu, WLen_HK
dc.contributor.authorKai, Hen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:52:55Z-
dc.date.available2010-09-06T07:52:55Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Virology, 2007, v. 81 n. 14, p. 7529-7539en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79292-
dc.description.abstractHighly pathogenic avian influenza (HPAI) H5N1 viruses are now endemic in many Asian countries, resulting in repeated outbreaks in poultry and increased cases of human infection. The immediate precursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96 (Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong, China, in 1996. From 2000 onwards, many novel reassortant H5N1 influenza viruses or genotypes have emerged in southern China. However, precursors of the Gs/GD-like viruses and their subsequent reassortants have not been fully determined. Here we characterize low-pathogenic avian influenza (LPAI) H5 subtype viruses isolated from poultry and migratory birds in southern China and Europe from the 1970s to the 2000s. Phylogenetic analyses revealed that Gs/GD-like virus was likely derived from an LPAI H5 virus in migratory birds. However, its variants arose from multiple reassortments between Gs/GD-like virus and viruses from migratory birds or with those Eurasian viruses isolated in the 1970s. It is of note that unlike HPAI H5N1 viruses, those recent LPAI H5 viruses have not become established in aquatic or terrestrial poultry. Phylogenetic analyses revealed the dynamic nature of the influenza virus gene pool in Eurasia with repeated transmissions between the eastern and western extremities of the continent. The data also show reassortment between influenza viruses from domestic and migratory birds in this region that has contributed to the expanded diversity of the influenza virus gene pool among poultry in Eurasia. Copyright © 2007, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.subject.meshAnimals-
dc.subject.meshBirds - Virology-
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Classification - Genetics - Isolation & Purification - Pathogenicity-
dc.subject.meshPhylogeny-
dc.titleCharacterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 virusesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=81&spage=7529&epage=7539&date=2007&atitle=Characterization+of+low+pathogenic+H5+subtype+influenza+viruses+from+Eurasia:+Implications+for+the+origin+of+highly+pathogenic+H5N1+virusesen_HK
dc.identifier.emailLeung, YHC: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityLeung, YHC=rp00307en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.00327-07en_HK
dc.identifier.pmid17507485-
dc.identifier.scopuseid_2-s2.0-34447272239en_HK
dc.identifier.hkuros130792en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447272239&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue14en_HK
dc.identifier.spage7529en_HK
dc.identifier.epage7539en_HK
dc.identifier.isiWOS:000247944100018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDuan, L=7201932765en_HK
dc.identifier.scopusauthoridCampitelli, L=6603632228en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridLeung, YHC=26531438300en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridDonatelli, I=7003277483en_HK
dc.identifier.scopusauthoridDelogu, M=6701330023en_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridFoni, E=6602949728en_HK
dc.identifier.scopusauthoridChiapponi, C=9235192700en_HK
dc.identifier.scopusauthoridWu, WL=16835478800en_HK
dc.identifier.scopusauthoridKai, H=36026396100en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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