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Article: Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses
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TitleCharacterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses
 
AuthorsDuan, L1 2
Campitelli, L6
Fan, XH1
Leung, YHC1
Vijaykrishna, D1 2
Zhang, JX1 2
Donatelli, I6
Delogu, M3
Li, KS2
Foni, E5
Chiapponi, C5
Wu, WL1 2
Kai, H1 2
Webster, RG1 4
Shortridge, KF1 2
Peiris, JSM1 2
Smith, GJD1 2
Chen, H1 2
Guan, Y1 2
 
Issue Date2007
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
CitationJournal Of Virology, 2007, v. 81 n. 14, p. 7529-7539 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00327-07
 
AbstractHighly pathogenic avian influenza (HPAI) H5N1 viruses are now endemic in many Asian countries, resulting in repeated outbreaks in poultry and increased cases of human infection. The immediate precursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96 (Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong, China, in 1996. From 2000 onwards, many novel reassortant H5N1 influenza viruses or genotypes have emerged in southern China. However, precursors of the Gs/GD-like viruses and their subsequent reassortants have not been fully determined. Here we characterize low-pathogenic avian influenza (LPAI) H5 subtype viruses isolated from poultry and migratory birds in southern China and Europe from the 1970s to the 2000s. Phylogenetic analyses revealed that Gs/GD-like virus was likely derived from an LPAI H5 virus in migratory birds. However, its variants arose from multiple reassortments between Gs/GD-like virus and viruses from migratory birds or with those Eurasian viruses isolated in the 1970s. It is of note that unlike HPAI H5N1 viruses, those recent LPAI H5 viruses have not become established in aquatic or terrestrial poultry. Phylogenetic analyses revealed the dynamic nature of the influenza virus gene pool in Eurasia with repeated transmissions between the eastern and western extremities of the continent. The data also show reassortment between influenza viruses from domestic and migratory birds in this region that has contributed to the expanded diversity of the influenza virus gene pool among poultry in Eurasia. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
 
ISSN0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
DOIhttp://dx.doi.org/10.1128/JVI.00327-07
 
ISI Accession Number IDWOS:000247944100018
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorDuan, L
 
dc.contributor.authorCampitelli, L
 
dc.contributor.authorFan, XH
 
dc.contributor.authorLeung, YHC
 
dc.contributor.authorVijaykrishna, D
 
dc.contributor.authorZhang, JX
 
dc.contributor.authorDonatelli, I
 
dc.contributor.authorDelogu, M
 
dc.contributor.authorLi, KS
 
dc.contributor.authorFoni, E
 
dc.contributor.authorChiapponi, C
 
dc.contributor.authorWu, WL
 
dc.contributor.authorKai, H
 
dc.contributor.authorWebster, RG
 
dc.contributor.authorShortridge, KF
 
dc.contributor.authorPeiris, JSM
 
dc.contributor.authorSmith, GJD
 
dc.contributor.authorChen, H
 
dc.contributor.authorGuan, Y
 
dc.date.accessioned2010-09-06T07:52:55Z
 
dc.date.available2010-09-06T07:52:55Z
 
dc.date.issued2007
 
dc.description.abstractHighly pathogenic avian influenza (HPAI) H5N1 viruses are now endemic in many Asian countries, resulting in repeated outbreaks in poultry and increased cases of human infection. The immediate precursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96 (Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong, China, in 1996. From 2000 onwards, many novel reassortant H5N1 influenza viruses or genotypes have emerged in southern China. However, precursors of the Gs/GD-like viruses and their subsequent reassortants have not been fully determined. Here we characterize low-pathogenic avian influenza (LPAI) H5 subtype viruses isolated from poultry and migratory birds in southern China and Europe from the 1970s to the 2000s. Phylogenetic analyses revealed that Gs/GD-like virus was likely derived from an LPAI H5 virus in migratory birds. However, its variants arose from multiple reassortments between Gs/GD-like virus and viruses from migratory birds or with those Eurasian viruses isolated in the 1970s. It is of note that unlike HPAI H5N1 viruses, those recent LPAI H5 viruses have not become established in aquatic or terrestrial poultry. Phylogenetic analyses revealed the dynamic nature of the influenza virus gene pool in Eurasia with repeated transmissions between the eastern and western extremities of the continent. The data also show reassortment between influenza viruses from domestic and migratory birds in this region that has contributed to the expanded diversity of the influenza virus gene pool among poultry in Eurasia. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Virology, 2007, v. 81 n. 14, p. 7529-7539 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00327-07
 
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.00327-07
 
dc.identifier.epage7539
 
dc.identifier.hkuros130792
 
dc.identifier.isiWOS:000247944100018
 
dc.identifier.issn0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
dc.identifier.issue14
 
dc.identifier.openurl
 
dc.identifier.pmid17507485
 
dc.identifier.scopuseid_2-s2.0-34447272239
 
dc.identifier.spage7529
 
dc.identifier.urihttp://hdl.handle.net/10722/79292
 
dc.identifier.volume81
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Virology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.
 
dc.subject.meshAnimals
 
dc.subject.meshBirds - Virology
 
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Classification - Genetics - Isolation & Purification - Pathogenicity
 
dc.subject.meshPhylogeny
 
dc.titleCharacterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses
 
dc.typeArticle
 
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<description.abstract>Highly pathogenic avian influenza (HPAI) H5N1 viruses are now endemic in many Asian countries, resulting in repeated outbreaks in poultry and increased cases of human infection. The immediate precursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96 (Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong, China, in 1996. From 2000 onwards, many novel reassortant H5N1 influenza viruses or genotypes have emerged in southern China. However, precursors of the Gs/GD-like viruses and their subsequent reassortants have not been fully determined. Here we characterize low-pathogenic avian influenza (LPAI) H5 subtype viruses isolated from poultry and migratory birds in southern China and Europe from the 1970s to the 2000s. Phylogenetic analyses revealed that Gs/GD-like virus was likely derived from an LPAI H5 virus in migratory birds. However, its variants arose from multiple reassortments between Gs/GD-like virus and viruses from migratory birds or with those Eurasian viruses isolated in the 1970s. It is of note that unlike HPAI H5N1 viruses, those recent LPAI H5 viruses have not become established in aquatic or terrestrial poultry. Phylogenetic analyses revealed the dynamic nature of the influenza virus gene pool in Eurasia with repeated transmissions between the eastern and western extremities of the continent. The data also show reassortment between influenza viruses from domestic and migratory birds in this region that has contributed to the expanded diversity of the influenza virus gene pool among poultry in Eurasia. Copyright &#169; 2007, American Society for Microbiology. All Rights Reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Shantou University
  3. Alma Mater Studiorum Università di Bologna
  4. St. Jude Children Research Hospital
  5. Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna Bruno Ubertini
  6. Istituto Superiore Di Sanita, Rome