Article: Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

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TitleIsolation and characterization of viruses related to the SARS coronavirus from animals in Southern China
AuthorsGuan, Y2
Zheng, BJ2
He, YQ1
Liu, XL1
Zhuang, ZX1
Cheung, CL2
Luo, SW2
Li, PH2
Zhang, LJ2
Guan, YJ2
Butt, KM2
Wong, KL2
Chan, KW2
Lim, W3
Shortridge, KF2
Yuen, KY2
Peiris, JSM2
Poon, LLM2
Issue Date2003
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
CitationScience, 2003, v. 302 n. 5643, p. 276-278 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.1087139
AbstractA novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.
ISSN0036-8075
2011 Impact Factor: 31.201
2011 SCImago Journal Rankings: 5.425
DOIhttp://dx.doi.org/10.1126/science.1087139
ISI Accession Number IDWOS:000185825900039
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorGuan, Y
dc.contributor.authorZheng, BJ
dc.contributor.authorHe, YQ
dc.contributor.authorLiu, XL
dc.contributor.authorZhuang, ZX
dc.contributor.authorCheung, CL
dc.contributor.authorLuo, SW
dc.contributor.authorLi, PH
dc.contributor.authorZhang, LJ
dc.contributor.authorGuan, YJ
dc.contributor.authorButt, KM
dc.contributor.authorWong, KL
dc.contributor.authorChan, KW
dc.contributor.authorLim, W
dc.contributor.authorShortridge, KF
dc.contributor.authorYuen, KY
dc.contributor.authorPeiris, JSM
dc.contributor.authorPoon, LLM
dc.date.accessioned2010-09-06T07:52:46Z
dc.date.available2010-09-06T07:52:46Z
dc.date.issued2003
dc.description.abstractA novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationScience, 2003, v. 302 n. 5643, p. 276-278 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.1087139
dc.identifier.doihttp://dx.doi.org/10.1126/science.1087139
dc.identifier.epage278
dc.identifier.hkuros83082
dc.identifier.isiWOS:000185825900039
dc.identifier.issn0036-8075
2011 Impact Factor: 31.201
2011 SCImago Journal Rankings: 5.425
dc.identifier.issue5643
dc.identifier.openurl
dc.identifier.pmid12958366
dc.identifier.scopuseid_2-s2.0-0141889936
dc.identifier.spage276
dc.identifier.urihttp://hdl.handle.net/10722/79280
dc.identifier.volume302
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
dc.publisher.placeUnited States
dc.relation.ispartofScience
dc.relation.referencesReferences in Scopus
dc.rightsScience. Copyright © American Association for the Advancement of Science.
dc.subject.meshAmino Acid Sequence
dc.subject.meshAnimals
dc.subject.meshAnimals, Wild - virology
dc.subject.meshAntibodies, Viral - blood
dc.subject.meshBlotting, Western
dc.subject.meshCarnivora - virology
dc.subject.meshChina
dc.subject.meshCoronavirus - classification - genetics - immunology - isolation & purification
dc.subject.meshCoronavirus Infections - veterinary - virology
dc.subject.meshDisease Reservoirs
dc.subject.meshFeces - virology
dc.subject.meshGenome, Viral
dc.subject.meshHumans
dc.subject.meshMembrane Glycoproteins - chemistry - genetics
dc.subject.meshMolecular Sequence Data
dc.subject.meshNeutralization Tests
dc.subject.meshNose - virology
dc.subject.meshOpen Reading Frames - genetics
dc.subject.meshPhylogeny
dc.subject.meshPolymorphism, Genetic
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshSARS Virus - classification - genetics - immunology - isolation & purification
dc.subject.meshSequence Deletion
dc.subject.meshSequence Homology, Nucleic Acid
dc.subject.meshViral Envelope Proteins - chemistry - genetics
dc.subject.meshViral Proteins - chemistry - genetics
dc.titleIsolation and characterization of viruses related to the SARS coronavirus from animals in Southern China
dc.typeArticle
Author Affiliations
  1. Shenzhen Center for Disease Control and Prevention
  2. The University of Hong Kong
  3. Government Virus Unit