File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong
  • Basic View
  • Metadata View
  • XML View
TitleMolecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong
 
AuthorsHo, PL2
Cheung, C2
Mak, GC2
Tse, CWS1
Ng, TK3
Cheung, CHY7
Que, TL4
Lam, R6
Lai, RWM6
Yung, RWH5
Yuen, KY2
 
Issue Date2007
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
CitationDiagnostic Microbiology And Infectious Disease, 2007, v. 57 n. 2, p. 145-151 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2006.08.003
 
AbstractThis study evaluated the clinical and epidemiologic features of individuals with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hong Kong from January 2004 through December 2005. Twenty-four episodes of skin and soft tissue infections and 1 episode of meningitis due to CA-MRSA were identified. CA-MRSA infections or carriage was found in 6 (13%) of 46 household contacts. A total of 29 isolates were analyzed by the Staphylococcus cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. In addition, polymerase chain reaction detection of the genes encoding Panton-Valentine leukocidin was also carried out. It was observed that 24 had SCCmec IV/IVA and 5 had SCCmec V, and 23 were pvl positive. PFGE analysis clustered all except 1 isolate into 3 pulsed-field types (PFTs), HKU100 through HKU300. The HKU100 isolates had genotype ST30-IV identical to the Southwest Pacific clone. The HKU200 isolates belonged to ST59-V and were multiresistant, including an ermB-mediated macrolide resistance trait, which is characteristic of the predominant CA-MRSA clone in Taiwan. The HKU300 isolates had unique features (ST8, Panton-Valentine leukocidin negative, and SCCmec IVA) typical of CA-MRSA in Japan. In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds. © 2007 Elsevier Inc. All rights reserved.
 
ISSN0732-8893
2013 Impact Factor: 2.568
2013 SCImago Journal Rankings: 1.275
 
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2006.08.003
 
ISI Accession Number IDWOS:000244085300005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorCheung, C
 
dc.contributor.authorMak, GC
 
dc.contributor.authorTse, CWS
 
dc.contributor.authorNg, TK
 
dc.contributor.authorCheung, CHY
 
dc.contributor.authorQue, TL
 
dc.contributor.authorLam, R
 
dc.contributor.authorLai, RWM
 
dc.contributor.authorYung, RWH
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2010-09-06T07:52:35Z
 
dc.date.available2010-09-06T07:52:35Z
 
dc.date.issued2007
 
dc.description.abstractThis study evaluated the clinical and epidemiologic features of individuals with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hong Kong from January 2004 through December 2005. Twenty-four episodes of skin and soft tissue infections and 1 episode of meningitis due to CA-MRSA were identified. CA-MRSA infections or carriage was found in 6 (13%) of 46 household contacts. A total of 29 isolates were analyzed by the Staphylococcus cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. In addition, polymerase chain reaction detection of the genes encoding Panton-Valentine leukocidin was also carried out. It was observed that 24 had SCCmec IV/IVA and 5 had SCCmec V, and 23 were pvl positive. PFGE analysis clustered all except 1 isolate into 3 pulsed-field types (PFTs), HKU100 through HKU300. The HKU100 isolates had genotype ST30-IV identical to the Southwest Pacific clone. The HKU200 isolates belonged to ST59-V and were multiresistant, including an ermB-mediated macrolide resistance trait, which is characteristic of the predominant CA-MRSA clone in Taiwan. The HKU300 isolates had unique features (ST8, Panton-Valentine leukocidin negative, and SCCmec IVA) typical of CA-MRSA in Japan. In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds. © 2007 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2007, v. 57 n. 2, p. 145-151 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2006.08.003
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2006.08.003
 
dc.identifier.epage151
 
dc.identifier.hkuros125899
 
dc.identifier.isiWOS:000244085300005
 
dc.identifier.issn0732-8893
2013 Impact Factor: 2.568
2013 SCImago Journal Rankings: 1.275
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid16989976
 
dc.identifier.scopuseid_2-s2.0-33846366339
 
dc.identifier.spage145
 
dc.identifier.urihttp://hdl.handle.net/10722/79265
 
dc.identifier.volume57
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
 
dc.relation.referencesReferences in Scopus
 
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiology - transmission
 
dc.subject.meshContact Tracing
 
dc.subject.meshFamily Characteristics
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshMale
 
dc.subject.meshMeningitis, Bacterial - epidemiology - microbiology - transmission
 
dc.subject.meshMethicillin Resistance
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMolecular Epidemiology
 
dc.subject.meshSoft Tissue Infections - epidemiology - microbiology - transmission
 
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology - transmission
 
dc.subject.meshStaphylococcal Skin Infections - epidemiology - microbiology - transmission
 
dc.subject.meshStaphylococcus aureus - drug effects - genetics
 
dc.titleMolecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ho, PL</contributor.author>
<contributor.author>Cheung, C</contributor.author>
<contributor.author>Mak, GC</contributor.author>
<contributor.author>Tse, CWS</contributor.author>
<contributor.author>Ng, TK</contributor.author>
<contributor.author>Cheung, CHY</contributor.author>
<contributor.author>Que, TL</contributor.author>
<contributor.author>Lam, R</contributor.author>
<contributor.author>Lai, RWM</contributor.author>
<contributor.author>Yung, RWH</contributor.author>
<contributor.author>Yuen, KY</contributor.author>
<date.accessioned>2010-09-06T07:52:35Z</date.accessioned>
<date.available>2010-09-06T07:52:35Z</date.available>
<date.issued>2007</date.issued>
<identifier.citation>Diagnostic Microbiology And Infectious Disease, 2007, v. 57 n. 2, p. 145-151</identifier.citation>
<identifier.issn>0732-8893</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/79265</identifier.uri>
<description.abstract>This study evaluated the clinical and epidemiologic features of individuals with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hong Kong from January 2004 through December 2005. Twenty-four episodes of skin and soft tissue infections and 1 episode of meningitis due to CA-MRSA were identified. CA-MRSA infections or carriage was found in 6 (13%) of 46 household contacts. A total of 29 isolates were analyzed by the Staphylococcus cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. In addition, polymerase chain reaction detection of the genes encoding Panton-Valentine leukocidin was also carried out. It was observed that 24 had SCCmec IV/IVA and 5 had SCCmec V, and 23 were pvl positive. PFGE analysis clustered all except 1 isolate into 3 pulsed-field types (PFTs), HKU100 through HKU300. The HKU100 isolates had genotype ST30-IV identical to the Southwest Pacific clone. The HKU200 isolates belonged to ST59-V and were multiresistant, including an ermB-mediated macrolide resistance trait, which is characteristic of the predominant CA-MRSA clone in Taiwan. The HKU300 isolates had unique features (ST8, Panton-Valentine leukocidin negative, and SCCmec IVA) typical of CA-MRSA in Japan. In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds. &#169; 2007 Elsevier Inc. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Elsevier Inc. The Journal&apos;s web site is located at http://www.elsevier.com/locate/diagmicrobio</publisher>
<relation.ispartof>Diagnostic Microbiology and Infectious Disease</relation.ispartof>
<rights>Diagnostic Microbiology and Infectious Disease. Copyright &#169; Elsevier Inc.</rights>
<subject.mesh>Adolescent</subject.mesh>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Aged, 80 and over</subject.mesh>
<subject.mesh>Child</subject.mesh>
<subject.mesh>Child, Preschool</subject.mesh>
<subject.mesh>Community-Acquired Infections - epidemiology - microbiology - transmission</subject.mesh>
<subject.mesh>Contact Tracing</subject.mesh>
<subject.mesh>Family Characteristics</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Hong Kong - epidemiology</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Infant</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Meningitis, Bacterial - epidemiology - microbiology - transmission</subject.mesh>
<subject.mesh>Methicillin Resistance</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Molecular Epidemiology</subject.mesh>
<subject.mesh>Soft Tissue Infections - epidemiology - microbiology - transmission</subject.mesh>
<subject.mesh>Staphylococcal Infections - epidemiology - microbiology - transmission</subject.mesh>
<subject.mesh>Staphylococcal Skin Infections - epidemiology - microbiology - transmission</subject.mesh>
<subject.mesh>Staphylococcus aureus - drug effects - genetics</subject.mesh>
<title>Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0732-8893&amp;volume=57&amp;issue=2&amp;spage=145&amp;epage=151&amp;date=2007&amp;atitle=Molecular+epidemiology+and+household+transmission+of+community-associated+methicillin-resistant+Staphylococcus+aureus+in+Hong+Kong</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.diagmicrobio.2006.08.003</identifier.doi>
<identifier.pmid>16989976</identifier.pmid>
<identifier.scopus>eid_2-s2.0-33846366339</identifier.scopus>
<identifier.hkuros>125899</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846366339&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>57</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>145</identifier.spage>
<identifier.epage>151</identifier.epage>
<identifier.isi>WOS:000244085300005</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Tuen Mun Hospital
  5. Centre for Health Protection
  6. Prince of Wales Hospital Hong Kong
  7. Pamela Youde Nethersole Eastern Hospital