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Article: Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong

TitleMolecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2007, v. 57 n. 2, p. 145-151 How to Cite?
AbstractThis study evaluated the clinical and epidemiologic features of individuals with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hong Kong from January 2004 through December 2005. Twenty-four episodes of skin and soft tissue infections and 1 episode of meningitis due to CA-MRSA were identified. CA-MRSA infections or carriage was found in 6 (13%) of 46 household contacts. A total of 29 isolates were analyzed by the Staphylococcus cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. In addition, polymerase chain reaction detection of the genes encoding Panton-Valentine leukocidin was also carried out. It was observed that 24 had SCCmec IV/IVA and 5 had SCCmec V, and 23 were pvl positive. PFGE analysis clustered all except 1 isolate into 3 pulsed-field types (PFTs), HKU100 through HKU300. The HKU100 isolates had genotype ST30-IV identical to the Southwest Pacific clone. The HKU200 isolates belonged to ST59-V and were multiresistant, including an ermB-mediated macrolide resistance trait, which is characteristic of the predominant CA-MRSA clone in Taiwan. The HKU300 isolates had unique features (ST8, Panton-Valentine leukocidin negative, and SCCmec IVA) typical of CA-MRSA in Japan. In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79265
ISSN
2014 Impact Factor: 2.457
2014 SCImago Journal Rankings: 1.021
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorMak, GCen_HK
dc.contributor.authorTse, CWSen_HK
dc.contributor.authorNg, TKen_HK
dc.contributor.authorCheung, CHYen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorLam, Ren_HK
dc.contributor.authorLai, RWMen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-06T07:52:35Z-
dc.date.available2010-09-06T07:52:35Z-
dc.date.issued2007en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2007, v. 57 n. 2, p. 145-151en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79265-
dc.description.abstractThis study evaluated the clinical and epidemiologic features of individuals with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hong Kong from January 2004 through December 2005. Twenty-four episodes of skin and soft tissue infections and 1 episode of meningitis due to CA-MRSA were identified. CA-MRSA infections or carriage was found in 6 (13%) of 46 household contacts. A total of 29 isolates were analyzed by the Staphylococcus cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. In addition, polymerase chain reaction detection of the genes encoding Panton-Valentine leukocidin was also carried out. It was observed that 24 had SCCmec IV/IVA and 5 had SCCmec V, and 23 were pvl positive. PFGE analysis clustered all except 1 isolate into 3 pulsed-field types (PFTs), HKU100 through HKU300. The HKU100 isolates had genotype ST30-IV identical to the Southwest Pacific clone. The HKU200 isolates belonged to ST59-V and were multiresistant, including an ermB-mediated macrolide resistance trait, which is characteristic of the predominant CA-MRSA clone in Taiwan. The HKU300 isolates had unique features (ST8, Panton-Valentine leukocidin negative, and SCCmec IVA) typical of CA-MRSA in Japan. In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiology - transmissionen_HK
dc.subject.meshContact Tracingen_HK
dc.subject.meshFamily Characteristicsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMeningitis, Bacterial - epidemiology - microbiology - transmissionen_HK
dc.subject.meshMethicillin Resistanceen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Epidemiologyen_HK
dc.subject.meshSoft Tissue Infections - epidemiology - microbiology - transmissionen_HK
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology - transmissionen_HK
dc.subject.meshStaphylococcal Skin Infections - epidemiology - microbiology - transmissionen_HK
dc.subject.meshStaphylococcus aureus - drug effects - geneticsen_HK
dc.titleMolecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-8893&volume=57&issue=2&spage=145&epage=151&date=2007&atitle=Molecular+epidemiology+and+household+transmission+of+community-associated+methicillin-resistant+Staphylococcus+aureus+in+Hong+Kongen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2006.08.003en_HK
dc.identifier.pmid16989976en_HK
dc.identifier.scopuseid_2-s2.0-33846366339en_HK
dc.identifier.hkuros125899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846366339&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue2en_HK
dc.identifier.spage145en_HK
dc.identifier.epage151en_HK
dc.identifier.isiWOS:000244085300005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridCheung, C=35357191500en_HK
dc.identifier.scopusauthoridMak, GC=8883252800en_HK
dc.identifier.scopusauthoridTse, CWS=7103295064en_HK
dc.identifier.scopusauthoridNg, TK=7402229817en_HK
dc.identifier.scopusauthoridCheung, CHY=35361304900en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridLam, R=7101916902en_HK
dc.identifier.scopusauthoridLai, RWM=8916364700en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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