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Article: Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

TitleGenesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2004, v. 430 n. 6996, p. 209-213 How to Cite?
AbstractA highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003-04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.
Persistent Identifierhttp://hdl.handle.net/10722/79255
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, KSen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorXu, KMen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorRahardjo, APen_HK
dc.contributor.authorPuthavathana, Pen_HK
dc.contributor.authorBuranathai, Cen_HK
dc.contributor.authorNguyen, TDen_HK
dc.contributor.authorEstoepangestie, ATSen_HK
dc.contributor.authorChaisingh, Aen_HK
dc.contributor.authorAuewarakui, Pen_HK
dc.contributor.authorLong, HTen_HK
dc.contributor.authorHanh, NTHen_HK
dc.contributor.authorWebby, RJen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-09-06T07:52:28Z-
dc.date.available2010-09-06T07:52:28Z-
dc.date.issued2004en_HK
dc.identifier.citationNature, 2004, v. 430 n. 6996, p. 209-213en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79255-
dc.description.abstractA highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003-04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBirds - virologyen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshFar East - epidemiologyen_HK
dc.subject.meshGenes, Viral - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza, Human - epidemiology - transmission - virologyen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshOrthomyxoviridae - genetics - isolation & purification - pathogenicityen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshReassortant Viruses - genetics - isolation & purification - pathogenicityen_HK
dc.subject.meshTime Factorsen_HK
dc.titleGenesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=430&issue=6996&spage=209&epage=13&date=2004&atitle=Genesis+of+a+highly+pathogenic+and+potentially+pandemic+H5N1+influenza+virus+in+eastern+Asia.en_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature02746en_HK
dc.identifier.pmid15241415-
dc.identifier.scopuseid_2-s2.0-3142579867en_HK
dc.identifier.hkuros94981en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142579867&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume430en_HK
dc.identifier.issue6996en_HK
dc.identifier.spage209en_HK
dc.identifier.epage213en_HK
dc.identifier.isiWOS:000222470600044-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridXu, KM=35228266300en_HK
dc.identifier.scopusauthoridDuan, L=7201932765en_HK
dc.identifier.scopusauthoridRahardjo, AP=6507883637en_HK
dc.identifier.scopusauthoridPuthavathana, P=7004642707en_HK
dc.identifier.scopusauthoridBuranathai, C=6507522489en_HK
dc.identifier.scopusauthoridNguyen, TD=25227791100en_HK
dc.identifier.scopusauthoridEstoepangestie, ATS=6504714500en_HK
dc.identifier.scopusauthoridChaisingh, A=12799046900en_HK
dc.identifier.scopusauthoridAuewarakui, P=6504578896en_HK
dc.identifier.scopusauthoridLong, HT=7102434129en_HK
dc.identifier.scopusauthoridHanh, NTH=6603275961en_HK
dc.identifier.scopusauthoridWebby, RJ=35448064800en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike465701-

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