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Article: Pathogenesis of severe acute respiratory syndrome

TitlePathogenesis of severe acute respiratory syndrome
Authors
Issue Date2005
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/coi
Citation
Current Opinion In Immunology, 2005, v. 17 n. 4 SPEC. ISS., p. 404-410 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is a zoonotic infectious disease caused by a novel coronavirus (CoV). The tissue tropism of SARS-CoV includes not only the lung, but also the gastrointestinal tract, kidney and liver. Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus. There is a prominent innate immune response to SARS-CoV infection, including acute-phase proteins, chemokines, inflammatory cytokines and C-type lectins such as mannose-binding lectin, which plays a protective role against SARS. By contrast there may be a lack of type 1 interferon response. Moreover, lymphopenia with decreased numbers of CD4+ and CD8 + T cells is common during the acute phase. Convalescent patients have IgG-class neutralizing antibodies that recognize amino acids 441-700 of the spike protein (S protein) as the major epitope. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79236
ISSN
2015 Impact Factor: 7.126
2015 SCImago Journal Rankings: 5.069
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, LLen_HK
dc.contributor.authorMalik Peiris, JSen_HK
dc.date.accessioned2010-09-06T07:52:14Z-
dc.date.available2010-09-06T07:52:14Z-
dc.date.issued2005en_HK
dc.identifier.citationCurrent Opinion In Immunology, 2005, v. 17 n. 4 SPEC. ISS., p. 404-410en_HK
dc.identifier.issn0952-7915en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79236-
dc.description.abstractSevere acute respiratory syndrome (SARS) is a zoonotic infectious disease caused by a novel coronavirus (CoV). The tissue tropism of SARS-CoV includes not only the lung, but also the gastrointestinal tract, kidney and liver. Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus. There is a prominent innate immune response to SARS-CoV infection, including acute-phase proteins, chemokines, inflammatory cytokines and C-type lectins such as mannose-binding lectin, which plays a protective role against SARS. By contrast there may be a lack of type 1 interferon response. Moreover, lymphopenia with decreased numbers of CD4+ and CD8 + T cells is common during the acute phase. Convalescent patients have IgG-class neutralizing antibodies that recognize amino acids 441-700 of the spike protein (S protein) as the major epitope. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/coien_HK
dc.relation.ispartofCurrent Opinion in Immunologyen_HK
dc.titlePathogenesis of severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0952-7915&volume=17&issue=4&spage=404&epage=410&date=2005&atitle=Pathogenesis+of+severe+acute+respiratory+syndromeen_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.coi.2005.05.009en_HK
dc.identifier.pmid15950449-
dc.identifier.scopuseid_2-s2.0-20544456584en_HK
dc.identifier.hkuros102018en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20544456584&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue4 SPEC. ISS.en_HK
dc.identifier.spage404en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000230673900011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, LL=8617704200en_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK

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