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Article: Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003

TitleEpidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
Authors
Issue Date2003
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2003, v. 362 n. 9393, p. 1353-1358 How to Cite?
AbstractBackground: An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province. Methods: We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent. Findings: SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world. Interpretation: SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries.
Persistent Identifierhttp://hdl.handle.net/10722/79224
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhong, NSen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorLi, YMen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorXie, ZHen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorLi, PHen_HK
dc.contributor.authorTan, SYen_HK
dc.contributor.authorChang, Qen_HK
dc.contributor.authorXie, JPen_HK
dc.contributor.authorLiu, XQen_HK
dc.contributor.authorXu, Jen_HK
dc.contributor.authorLi, DXen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:52:05Z-
dc.date.available2010-09-06T07:52:05Z-
dc.date.issued2003en_HK
dc.identifier.citationLancet, 2003, v. 362 n. 9393, p. 1353-1358en_HK
dc.identifier.issn0140-6736en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79224-
dc.description.abstractBackground: An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province. Methods: We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent. Findings: SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world. Interpretation: SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries.en_HK
dc.languageengen_HK
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_HK
dc.relation.ispartofLanceten_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshDisease Outbreaks - statistics & numerical dataen_HK
dc.subject.meshHumansen_HK
dc.subject.meshSARS Virus - genetics - immunology - isolation & purificationen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - microbiologyen_HK
dc.titleEpidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0140-6736&volume=362&issue=9393&spage=1353&epage=8&date=2003&atitle=Epidemiology+and+cause+of+severe+acute+respiratory+syndrome+(SARS)+in+Guangdong,+People%27s+Republic+of+China,+in+February,+2003en_HK
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0140-6736(03)14630-2en_HK
dc.identifier.pmid14585636en_HK
dc.identifier.scopuseid_2-s2.0-10744228014en_HK
dc.identifier.hkuros87577en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744228014&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume362en_HK
dc.identifier.issue9393en_HK
dc.identifier.spage1353en_HK
dc.identifier.epage1358en_HK
dc.identifier.isiWOS:000186143300008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhong, NS=7102137996en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridLi, YM=17434341700en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridXie, ZH=37044248800en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridLi, PH=15127492900en_HK
dc.identifier.scopusauthoridTan, SY=8272779200en_HK
dc.identifier.scopusauthoridChang, Q=36889312700en_HK
dc.identifier.scopusauthoridXie, JP=7402994715en_HK
dc.identifier.scopusauthoridLiu, XQ=12545657000en_HK
dc.identifier.scopusauthoridXu, J=7407005993en_HK
dc.identifier.scopusauthoridLi, DX=26632045000en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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