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Article: Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: A case control study

TitleSex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: A case control study
Authors
Issue Date2007
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2007, v. 7 How to Cite?
AbstractBackground: Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphisms and TB. Methods: A case-control study was conducted. In total, 278 pulmonary TB patients and 282 sex- and age-matched controls without TB were recruited. All subjects were ethnic Chinese. On the basis of linkage disequilibrium pattern, three genetic markers from SLC11A1 and one from the nearby IL8RB locus were selected and examined for association with TB susceptibility. These markers were genotyped using single strand conformation polymorphism analysis or fragment analysis of amplified products. Results: Statistically significant differences in allele (P = 0.0165, OR = 1.51) and genotype (P = 0.0163, OR = 1.59) frequencies of the linked markers SLC6a/b (classically called D543N and 3'UTR) of the SLC11A1 locus were found between patients and controls. With stratification by sex, positive associations were identified in the female group for both allele (P = 0.0049, OR = 2.54) and genotype (P = 0.0075, OR = 2.74) frequencies. With stratification by age, positive associations were demonstrated in the young age group (age ≤65 years) for both allele (P = 0.0047, OR = 2.52) and genotype (P = 0.0031, OR = 2.92) frequencies. All positive findings remained significant even after correction for multiple comparisons. No significant differences were noted in either the male group or the older age group. No significant differences were found for the other markers (one SLC11A1 marker and one IL8RB marker) either. Conclusion: This study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group. © 2007 Leung et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/79194
ISSN
2015 Impact Factor: 2.69
2015 SCImago Journal Rankings: 1.510
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KHen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorYiu, LSen_HK
dc.contributor.authorChan, KKen_HK
dc.contributor.authorLai, WMen_HK
dc.contributor.authorChow, EYDen_HK
dc.contributor.authorLin, CKen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorChan, KSen_HK
dc.date.accessioned2010-09-06T07:51:44Z-
dc.date.available2010-09-06T07:51:44Z-
dc.date.issued2007en_HK
dc.identifier.citationBmc Infectious Diseases, 2007, v. 7en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79194-
dc.description.abstractBackground: Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphisms and TB. Methods: A case-control study was conducted. In total, 278 pulmonary TB patients and 282 sex- and age-matched controls without TB were recruited. All subjects were ethnic Chinese. On the basis of linkage disequilibrium pattern, three genetic markers from SLC11A1 and one from the nearby IL8RB locus were selected and examined for association with TB susceptibility. These markers were genotyped using single strand conformation polymorphism analysis or fragment analysis of amplified products. Results: Statistically significant differences in allele (P = 0.0165, OR = 1.51) and genotype (P = 0.0163, OR = 1.59) frequencies of the linked markers SLC6a/b (classically called D543N and 3'UTR) of the SLC11A1 locus were found between patients and controls. With stratification by sex, positive associations were identified in the female group for both allele (P = 0.0049, OR = 2.54) and genotype (P = 0.0075, OR = 2.74) frequencies. With stratification by age, positive associations were demonstrated in the young age group (age ≤65 years) for both allele (P = 0.0047, OR = 2.52) and genotype (P = 0.0031, OR = 2.92) frequencies. All positive findings remained significant even after correction for multiple comparisons. No significant differences were noted in either the male group or the older age group. No significant differences were found for the other markers (one SLC11A1 marker and one IL8RB marker) either. Conclusion: This study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group. © 2007 Leung et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsB M C Infectious Diseases. Copyright © BioMed Central Ltd.en_HK
dc.titleSex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: A case control studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=7:19&spage=&epage=&date=2007&atitle=Sex-+and+age-dependent+association+of+SLC11A1+polymorphisms+with+tuberculosis+in+Chinese:+A+case+control+study++en_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1471-2334-7-19en_HK
dc.identifier.scopuseid_2-s2.0-34147178250en_HK
dc.identifier.hkuros137458en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34147178250&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.isiWOS:000245448100001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, KH=7401860469en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridWong, WS=16204379900en_HK
dc.identifier.scopusauthoridYiu, LS=13204244000en_HK
dc.identifier.scopusauthoridChan, KK=35073540100en_HK
dc.identifier.scopusauthoridLai, WM=7402230436en_HK
dc.identifier.scopusauthoridChow, EYD=7102595571en_HK
dc.identifier.scopusauthoridLin, CK=12752556900en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridChan, KS=7406031627en_HK
dc.identifier.citeulike1178415-

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