File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of tumour necrosis factor aplha and interleukin 6 levels with cytomegalovirus DNA detection and disease after renal transplantation

TitleAssociation of tumour necrosis factor aplha and interleukin 6 levels with cytomegalovirus DNA detection and disease after renal transplantation
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal of Medical Virology, 2001, v. 64 n. 1, p. 29-34 How to Cite?
AbstractCytokines such as tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) are thought to be important in the pathogenesis of post-transplant cytomegalovirus (CMV) disease. CMV infection increases the production of TNF-α and IL-6. Conversely, TNF-α switches on the replication of CMV. To study the association of these two cytokines with CMV activity and disease, TNF-α and IL-6 levels were assayed in plasma samples taken serially from three groups of renal transplant recipients. Group A (n = 12) had CMV disease and syndrome; Group B (n = 11) had detectable CMV DNA in plasma or peripheral blood leucocytes without disease, i.e., presumed asymptomatic CMV infection, and Group C (n = 11) had no detectable CMV DNA nor disease. The median peak TNF-α levels in patients with CMV disease (Group A) were significantly higher than that in Group B or Group C (P < 0.02) whereas the median peak IL-6 levels in group C patients were significantly lower than that in group A (P < 0.04) or group B (P < 0.03). A TNF-α level of above 100 pg/ml was significantly associated with CMV disease and high plasma CMV load (> 10,000 copies/ml). IL-6 levels above 15 pg/ml were significantly associated with CMV DNA detection, but not with CMV disease or elevated CMV load. High levels of TNF-α or IL-6 were not associated with CMV donor/recipient serostatus, HHV-6 or HHV-7 DNA detection, immunosuppressive regimen or rejection episodes. The role of TNF-α in the pathogenesis of CMV disease deserves further investigation. J. Med. Virol. 64:29–34, 2001. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/79185
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015

 

DC FieldValueLanguage
dc.contributor.authorTong, CYW-
dc.contributor.authorBakran, A-
dc.contributor.authorWilliams, H-
dc.contributor.authorCuevas, LE-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorHart, CA-
dc.date.accessioned2010-09-06T07:51:38Z-
dc.date.available2010-09-06T07:51:38Z-
dc.date.issued2001-
dc.identifier.citationJournal of Medical Virology, 2001, v. 64 n. 1, p. 29-34-
dc.identifier.issn0146-6615-
dc.identifier.urihttp://hdl.handle.net/10722/79185-
dc.description.abstractCytokines such as tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) are thought to be important in the pathogenesis of post-transplant cytomegalovirus (CMV) disease. CMV infection increases the production of TNF-α and IL-6. Conversely, TNF-α switches on the replication of CMV. To study the association of these two cytokines with CMV activity and disease, TNF-α and IL-6 levels were assayed in plasma samples taken serially from three groups of renal transplant recipients. Group A (n = 12) had CMV disease and syndrome; Group B (n = 11) had detectable CMV DNA in plasma or peripheral blood leucocytes without disease, i.e., presumed asymptomatic CMV infection, and Group C (n = 11) had no detectable CMV DNA nor disease. The median peak TNF-α levels in patients with CMV disease (Group A) were significantly higher than that in Group B or Group C (P < 0.02) whereas the median peak IL-6 levels in group C patients were significantly lower than that in group A (P < 0.04) or group B (P < 0.03). A TNF-α level of above 100 pg/ml was significantly associated with CMV disease and high plasma CMV load (> 10,000 copies/ml). IL-6 levels above 15 pg/ml were significantly associated with CMV DNA detection, but not with CMV disease or elevated CMV load. High levels of TNF-α or IL-6 were not associated with CMV donor/recipient serostatus, HHV-6 or HHV-7 DNA detection, immunosuppressive regimen or rejection episodes. The role of TNF-α in the pathogenesis of CMV disease deserves further investigation. J. Med. Virol. 64:29–34, 2001. © 2001 Wiley-Liss, Inc.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763-
dc.relation.ispartofJournal of Medical Virology-
dc.rightsJournal of Medical Virology. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subject.meshCytomegalovirus - isolation & purification - physiology-
dc.subject.meshCytomegalovirus Infections - blood - etiology - immunology-
dc.subject.meshInterleukin-6 - blood-
dc.subject.meshKidney Transplantation - adverse effects - immunology-
dc.subject.meshTumor Necrosis Factor-alpha - metabolism-
dc.titleAssociation of tumour necrosis factor aplha and interleukin 6 levels with cytomegalovirus DNA detection and disease after renal transplantation-
dc.typeArticle-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0146-6615&volume=64&spage=29&epage=34&date=2001&atitle=Association+of+tumour+necrosis+factor+aplha+and+interleukin+6+levels+with+cytomegalovirus+DNA+detection+and+disease+after+renal+transplantation.en_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.doi10.1002/jmv.1013-
dc.identifier.pmid11285565-
dc.identifier.hkuros60554-
dc.identifier.volume64-
dc.identifier.issue1-
dc.identifier.spage29-
dc.identifier.epage34-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats