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Article: Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones

TitleTarget site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones
Authors
Issue Date2001
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
Citation
Journal Of Antimicrobial Chemotherapy, 2001, v. 47 n. 5, p. 655-658 How to Cite?
AbstractCiprofloxacin-susceptible (n = 7) and -resistant (MIC ≥4 mg/L) (n = 15) clinical isolates of Streptococcus pneumoniae from diverse sources in Hong Kong were studied for target site modifications and efflux phenotype. Reserpine-inhibited efflux of ciprofloxacin and/or levofloxacin was common in both susceptible and non-susceptible isolates. The ParC substitutions K137N and/or S79F or Y were associated with increased ciprofloxacin MICs. The GyrA substitution S81F was only found in isolates with full resistance to ciprofloxacin (MIC ≥ 16 mg/L) and levofloxacin (MIC ≥ 8 mg/L). Among clinical isolates of S. pneumoniae, accumulation of target site mutations in strains with an efflux mechanism was associated with increasing MICs of fluoroquinolones.
Persistent Identifierhttp://hdl.handle.net/10722/79163
ISSN
2015 Impact Factor: 4.919
2015 SCImago Journal Rankings: 2.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorTsang, DNCen_HK
dc.contributor.authorSeto, WHen_HK
dc.contributor.authorNg, TKen_HK
dc.contributor.authorNg, WSen_HK
dc.date.accessioned2010-09-06T07:51:21Z-
dc.date.available2010-09-06T07:51:21Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Antimicrobial Chemotherapy, 2001, v. 47 n. 5, p. 655-658en_HK
dc.identifier.issn0305-7453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79163-
dc.description.abstractCiprofloxacin-susceptible (n = 7) and -resistant (MIC ≥4 mg/L) (n = 15) clinical isolates of Streptococcus pneumoniae from diverse sources in Hong Kong were studied for target site modifications and efflux phenotype. Reserpine-inhibited efflux of ciprofloxacin and/or levofloxacin was common in both susceptible and non-susceptible isolates. The ParC substitutions K137N and/or S79F or Y were associated with increased ciprofloxacin MICs. The GyrA substitution S81F was only found in isolates with full resistance to ciprofloxacin (MIC ≥ 16 mg/L) and levofloxacin (MIC ≥ 8 mg/L). Among clinical isolates of S. pneumoniae, accumulation of target site mutations in strains with an efflux mechanism was associated with increasing MICs of fluoroquinolones.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/en_HK
dc.relation.ispartofJournal of Antimicrobial Chemotherapyen_HK
dc.rightsJournal of Antimicrobial Chemotherapy. Copyright © Oxford University Press.en_HK
dc.subject.meshAmino Acid Substitutionen_HK
dc.subject.meshAnti-Infective Agents - pharmacologyen_HK
dc.subject.meshBacterial Proteins - geneticsen_HK
dc.subject.meshBiological Transporten_HK
dc.subject.meshDrug Resistance, Microbial - genetics - physiologyen_HK
dc.subject.meshFluoroquinolonesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshStreptococcus pneumoniae - drug effects - genetics - metabolismen_HK
dc.titleTarget site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolonesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-7453&volume=47&spage=655&epage=658&date=2001&atitle=Target+site+modifications+and+efflux+phenotype+in+clinical+isolates+of+Streptococcus+pneumoniae+from+Hong+Kong+with+reduced+susceptibility+to+fluoroquinolonesen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11328779-
dc.identifier.scopuseid_2-s2.0-0035011959en_HK
dc.identifier.hkuros60648en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035011959&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue5en_HK
dc.identifier.spage655en_HK
dc.identifier.epage658en_HK
dc.identifier.isiWOS:000168839000021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridTsang, DNC=7005609132en_HK
dc.identifier.scopusauthoridSeto, WH=36950521100en_HK
dc.identifier.scopusauthoridNg, TK=7402229817en_HK
dc.identifier.scopusauthoridNg, WS=36787042500en_HK

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