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Article: Clarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model

TitleClarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model
Authors
Issue Date1999
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618
Citation
Pharmacological Research, 1999, v. 39 n. 1, p. 49-54 How to Cite?
AbstractThe effect of clarithromycin on the systemic and local inflammatory responses after surgical trauma was investigated using a guinea pig model. There was no statistically significant difference in the body temperature and respiratory rate of the guinea pigs between the clarithromycin and control groups, although there was a trend towards a lower temperature in the first 36 h after the operation, and a trend towards a lower respiratory rate on day 1 and day 2 (P = 0.07 and 0.18, respectively) in the clarithromycin group. The total leukocyte count of both groups of animals increased from day -1 to day 4, and the increase was more marked in the control group (P = 0.06 on day 1). The neutrophil and monocyte counts of the two groups of animals also increased after the operation. The neutrophil count of the control group was significantly higher than the clarithromycin group on day 1 and 2 (P < 0.05 and 0.01, respectively), and the monocyte count of the control group was significantly higher than the clarithromycin group on day 1 (P < 0.005). Moreover, the platelet count of the animals also increased after the operation, and the count in the control group was significantly higher than the clarithromycin group on day 1, 2 and 4 (P < 0.05, 0.005 and 0.005, respectively). There was no difference between the haemoglobin concentration, lymphocyte count, eosinophil count and basophil count between the two groups of animals. The number of animals with wound discharge was lower in the clarithromycin group than the control group throughout the post-operative period, but the difference was not statistically significant. None of the animals developed signs of wound infection. The present observation suggests that clarithromycin suppressed both the systemic and local inflammatory response after surgical trauma, and it prompts further animal experiments for delineation of the mechanism of action, as well as clinical trials in major surgical procedures.
Persistent Identifierhttp://hdl.handle.net/10722/79153
ISSN
2015 Impact Factor: 4.816
2015 SCImago Journal Rankings: 2.108
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-06T07:51:14Z-
dc.date.available2010-09-06T07:51:14Z-
dc.date.issued1999en_HK
dc.identifier.citationPharmacological Research, 1999, v. 39 n. 1, p. 49-54en_HK
dc.identifier.issn1043-6618en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79153-
dc.description.abstractThe effect of clarithromycin on the systemic and local inflammatory responses after surgical trauma was investigated using a guinea pig model. There was no statistically significant difference in the body temperature and respiratory rate of the guinea pigs between the clarithromycin and control groups, although there was a trend towards a lower temperature in the first 36 h after the operation, and a trend towards a lower respiratory rate on day 1 and day 2 (P = 0.07 and 0.18, respectively) in the clarithromycin group. The total leukocyte count of both groups of animals increased from day -1 to day 4, and the increase was more marked in the control group (P = 0.06 on day 1). The neutrophil and monocyte counts of the two groups of animals also increased after the operation. The neutrophil count of the control group was significantly higher than the clarithromycin group on day 1 and 2 (P < 0.05 and 0.01, respectively), and the monocyte count of the control group was significantly higher than the clarithromycin group on day 1 (P < 0.005). Moreover, the platelet count of the animals also increased after the operation, and the count in the control group was significantly higher than the clarithromycin group on day 1, 2 and 4 (P < 0.05, 0.005 and 0.005, respectively). There was no difference between the haemoglobin concentration, lymphocyte count, eosinophil count and basophil count between the two groups of animals. The number of animals with wound discharge was lower in the clarithromycin group than the control group throughout the post-operative period, but the difference was not statistically significant. None of the animals developed signs of wound infection. The present observation suggests that clarithromycin suppressed both the systemic and local inflammatory response after surgical trauma, and it prompts further animal experiments for delineation of the mechanism of action, as well as clinical trials in major surgical procedures.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618en_HK
dc.relation.ispartofPharmacological Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.subject.meshBlood Platelets - drug effectsen_HK
dc.subject.meshBody Temperature - drug effectsen_HK
dc.subject.meshClarithromycin - pharmacologyen_HK
dc.subject.meshGuinea Pigsen_HK
dc.subject.meshHemoglobins - drug effectsen_HK
dc.subject.meshInflammation - prevention & controlen_HK
dc.subject.meshLeukocytes - drug effectsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMuscle, Skeletalen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRespiration - drug effectsen_HK
dc.subject.meshShock, Surgical - complicationsen_HK
dc.subject.meshWound Healing - drug effectsen_HK
dc.subject.meshWound Infection - pathologyen_HK
dc.titleClarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1043-6618&volume=39&spage=49&epage=54&date=1998&atitle=Clarithromycin+attenuates+the+inflammatory+response+induced+by+surgical+trauma+in+a+guinea+pig+modelen_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/phrs.1998.0400en_HK
dc.identifier.pmid10051377-
dc.identifier.scopuseid_2-s2.0-0033059971en_HK
dc.identifier.hkuros37711en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033059971&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue1en_HK
dc.identifier.spage49en_HK
dc.identifier.epage54en_HK
dc.identifier.isiWOS:000078812900007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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